Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A modified passive cutaneous anaphylaxis test and an ELISA were used to identify IgE in calves vaccinated (sensitized) with chlorine dioxide-inactivated bluetongue virus (BTV) and in calves inoculated with infectious BTV. The levels of IgE were greatest in the vaccinated calves after challenge with infectious virus, which correlated with development of clinically apparent dermatitis and stomatitis. These findings suggest that some aspects of clinical bluetongue disease in cattle may have an immunopathological mechanism mediated by IgE (type I hypersensitivity).
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PMID:Identification of bluetongue virus-specific immunoglobulin E in cattle. 282 Nov 88

The effects of environmental factors in the morbidity pattern of 893 children under 5 years of age living in the urban, urban slum, and rural areas of Varanasi are investigated. 273 children belonged to an urban area, 284 to urban slum area, and 336 to a rural area. All 3 areas have general outpatient services as well as underfive clinics. Data on childrearing practices, anthropometric measurements, and morbidity are recorded in the health cards of the children. Various illnesses observed included gastroenteritis, upper respiratory tract infection, stomatitis, constipation, fever, pica, anemia, Vitamin A deficiency, measles, chicken pox, whooping cough, and others. Total illnesses per child were higher in urban slum and rural children compared to the urban group (chi-square=132.7, p0.001). Children who lived in pucca and mixed houses in urban slum and rural areas had significantly higher morbidity compared to the urban group (pucca houses, chi-square=77.01, p0.01; mixed houses, chi-square=16.98, p0.001). The incidence of morbidity was higher in children who lived in inadequately ventilated kachcha houses, had poor source of water supply through open wells and practiced open field defecation compared to those who lived in pucca houses with adequate ventilation, utilized tap water, and were using service latrines. The findings suggest the need to educate mothers and to improve sanitation in order to maintain hygienic conditions for improving the health status of the children. A safe drinking water scheme should be immediately instituted in the crowded urban slums or rural areas. The few wells in villages should be improved and water chlorinated by bleaching powder or chlorine tablets.
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PMID:Influence of environmental factors on underfive morbidity. 730 16

The effects of three representative disinfectants, chlorine (sodium hypochlorite), iodine (potassium tetraglicine triiodide), and quaternary ammonium compound (didecyldimethylammonium chloride), on several exotic disease viruses were examined. The viruses used were four enveloped viruses (vesicular stomatitis virus, African swine fever virus, equine viral arteritis virus, and porcine reproductive and respiratory syndrome virus) and two non-enveloped viruses (swine vesicular disease virus (SVDV) and African horse sickness virus (AHSV)). Chlorine was effective against all viruses except SVDV at concentrations of 0.03% to 0.0075%, and a dose response was observed. Iodine was very effective against all viruses at concentrations of 0.015% to 0.0075%, but a dose response was not observed. Quaternary ammonium compound was very effective in low concentration of 0.003% against four enveloped viruses and AHSV, but it was only effective against SVDV with 0.05% NaOH. Electron microscopic observation revealed the probable mechanism of each disinfectant. Chlorine caused complete degeneration of the viral particles and also destroyed the nucleic acid of the viruses. Iodine destroyed mainly the inner components including nucleic acid of the viruses. Quaternary ammonium compound induced detachment of the envelope of the enveloped viruses and formation of micelle in non-enveloped viruses. According to these results, chlorine and iodine disinfectants were quite effective against most of the viruses used at adequately high concentration. The effective concentration of quaternary ammonium compound was the lowest among the disinfectants examined.
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PMID:Effects of chlorine, iodine, and quaternary ammonium compound disinfectants on several exotic disease viruses. 1067 96

Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC50 values of 1.92, 0.53, and 1.99 microg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.
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PMID:Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus. 1740 23