Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Side-effects from dental materials are a minor problem, but should be recognized. In recent questionnaire surveys about side-effects, the incidence was estimated to be 1:300 in periodontics and 1:2600 in pedodontics. None of these reactions was related to dental casting alloys. In prosthodontics, the incidence was calculated to be about 1:400, and about 27% were related to base-metal alloys for removable partial dentures (cobalt, chromium, nickel) and to noble/gold-based alloys for porcelain-fused-to-metal restorations. The complaints consisted of intra-oral reactions (such as redness, swelling, and pain of the oral mucosa and lips), oral/gingival lichenoid reactions, and a few instances of systemic reactions. In orthodontics, the incidence was 1:100, and most reactions (85%) were related to metal parts of the extra-oral anchorage devices. Even though the extensive use of base-metal alloys has been of major concern to the dental profession, relatively few case reports substantiate this concern. Allergy to gold-based dental restorations has been more commonly reported. Palladium-based alloys have been associated with several cases of stomatitis and oral lichenoid reactions. Palladium allergy seems to occur mainly in patients who are very sensitive to nickel. All casting alloys, except titanium, seem to have a potential for eliciting adverse reactions in individual hypersensitive patients. Tolerance induction may be a possible benefit of the use of intra-orally placed alloys. In non-sensitized individuals, oral antigenic contacts to nickel and chromium may induce tolerance rather than sensitization. A variety of systemic diseases and reactions has been claimed to be caused by dental materials. The claims are generally poorly documented.
 ...
PMID:Casting alloys: side-effects. 129 60

Some patients with prostheses or dental material containing nickel have been diagnosed as suffering from stomatitis. These lesions of the oral mucosa are sometimes difficult to interpret since allergies are not always taken into consideration. The paper reports a case of stomatitis due to nickel allergy and describes the diagnostic procedure [correction of iter] followed in order to diagnose the true nature of the pathology.
 ...
PMID:[A case of nickel-induced stomatitis]. 207 68

The fundamental basis of allergy, particularly in relation to contact allergy, is described, together with the importance and frequency of sensitization to nickel, chromium and cobalt in both the consultant and general population. 139 published cases of allergy to dental restorations containing these metals are reviewed involving 92 female and 47 male patients, 115 of whom recovered when the restorations were removed. The most frequent symptoms were local (99/139), particularly gingivitis and stomatitis, while general or remote symptoms occurred in 33 cases. This probably underestimates the true prevalence of the condition, because a large number of reported cases have not been due to their "current appearance". The influence of the occupational environment of the patient is described with special reference to dental technicians. The persistence of contact allergy to metals for which no desensitization is possible is also emphasised. The discussion includes experimental investigations and an appraisal of other methods of revealing hypersensitivity. Finally, some simple recommendations for prevention are made which are of value to practitioners.
 ...
PMID:[Non-precious metal dental alloys and allergy]. 253 99

Possible correlations between allergic reactions and the significance of a dental prosthesis or restoration made from one or more of the metals nickel, cobalt and chromium are considered. Described clinical cases are reviewed. These allergic reactions may appear either locally as stomatitis or distantly in the form of general or local contact dermatitis.
 ...
PMID:Nickel, chromium, cobalt dental alloys and allergic reactions: an overview. 269 Sep 62

The role of essential fatty acids in membrane functions related to receptor-mediated endocytosis of vesicular stomatitis virus (VSV) was investigated using a human laryngeal carcinoma cell line (HEp-2) grown in chemically defined serum-free medium (DM) to deplete their essential fatty acid contents. VSV replicated much less effectively in HEp-2 cells grown in DM as compared to serum containing complete medium (CM). Observed reduction in the rate of virus multiplication was, at least in part, due to reduced virus penetration which was monitored using VSV labeled with nitroxyl free radicals as electron spin probe. Surface proteins of VSV were labeled with maleimide spin-label, and succinimide spin-label. Ni2+ was used as a broadening agent to identify the spin-label signals from viruses inside the cell. HEp-2 cells and mouse leukemia cell line L1210 treated with 5-dimethylaminonaphthalene-1-sulfonyl (dansyl) cadaverine, an agent previously shown to inhibit the uptake of VSV in vitro, was used as a positive control in some experiments. VSV penetrated less effectively in both DM-grown cells and in CM-grown cells in the presence of dansylcadaverine. Similar results were obtained by monitoring the uptake of 125I-labeled VSV. When HEp-2 cells grown for several generations in DM were incubated with 10% fetal calf serum for 16 h, the cells supported virus replication to a similar extent as the cells grown in CM. In contrast, addition of arachidonic acid restored VSV growth only partially. Continued growth of HEp-2 cells in DM resulted in a shift in fatty acyl chain composition of phospholipids. The results indicate a finite role for essential fatty acids in receptor-mediated internalization of virus particles.
 ...
PMID:Role of cell membrane composition in receptor-mediated internalization of vesicular stomatitis virus in human HEp-2 cells. 298 85

An in vivo comparison was made between the contact allergic stomatitis-inducing capacity of nickel, nickel-containing dental alloys and a non-corrosive precious metal. Fifteen patients with a positive allergic skin reaction to nickel were divided into 3 groups (A, B and C). The patients in Group A (n = 4) were fitted with an intra-oral corrosion-resistant nickel-chromium Alloy A; the patients of Group B (n = 5) received a more corrosion prone nickel-chromium Alloy B and in Group C (n = 6) strongly corroding pure nickel was used. A corrosion-resistant foil of pure palladium was placed on the contralateral side. Reactivity of pure nickel foil was also tested on the skin in Group C. Immunohistological examination of the oral mucosa on the test and reference sides was performed with monoclonal antibodies directed against T-lymphocyte subsets and Langerhans cells (LC). The results showed that at the pure nickel site the LC did increase significantly in the connective tissue (approx. 4X) of the oral mucosa. However, statistical analysis of all 6 patients of Group C together showed no corresponding increase of LC in the epithelium at the site with the pure nickel, although a numerical increase of LC was noted in the epithelium adjacent to the pure nickel foil in 2 patients, which was remarkable. It can be concluded from statistical analysis that both the reference foils and the test foils can influence the number of suppressor/cytotoxic T-lymphocytes in the connective tissue.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:T-lymphocyte and Langerhans cell distribution in normal and allergically induced oral mucosa in contact with nickel-containing dental alloys. 313 74

Some alloys used in restorative dentistry may evoke an allergic contact stomatitis in certain persons. In order to protect patients from materials with undesired reactions, and considering corrosion characteristics of different alloys used, it is useful to devise an adequate patch test battery to include the most relevant metals. Dental alloys are composed of a combination of various metals. 12 different ions of frequent occurrence (Au3+, Pd2+, Zn2+, Mo6+, Sn2+, Ga3+, In3+, Co2+, Cr3+(6+), Ni2+, Fe2+(3+) and Si4+) were epicutaneously tested as the aqueous solution of the respective salt. The concentrations are given in g/100 ml and also in m.mole/l. The 12 different metal ion solutions were patch tested on patients in 3 groups: one group with a positive history of contact stomatitis (30 patients, group 1), one group with a positive history of contact dermatitis (16 patients, group 2), and a control group (17 persons, group 3). In contrast to the control group, a remarkable high percentage (11%) of positive skin reactions to Pd was found in groups 1 and 2. No allergic or irritant skin reactions were detected to Ga, Sn and Zn. No irritant reaction was observed at pH values as low as 1.5. In the case of SiCl4 (pH = 0.5), 41% positive irritant reactions were evoked. In the group with a positive history of contact dermatitis (group 1), a positive reaction was found more often (69%) than in the group with a positive history of contact stomatitis (30%) (group 2). The difference between these groups was mainly caused by reactions to Ni and Pd.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Test battery for metal allergy in dentistry. 370 61

17 subjects were tested epicutaneously with 22 materials, including Ni, Pd, Cr and Co. 5 subjects with a positive allergic skin reaction to Ni were tested with a pure metallic nickel plate 3 X 5 mm, which was attached to the buccal side of one lower premolar. These 5 subjects all developed local allergic contact stomatitis on the mucosa of the cheek adjacent to the metal plate. This was confirmed histologically. The same oral test with pure metallic palladium gave no reaction in subjects with a positive patch test. A control group gave no reactions to the metal plates. Allergic contact stomatitis was diagnosed with the help of both clinical and histological examinations.
 ...
PMID:Contact stomatitis and dermatitis to nickel and palladium. 652 23

5 patients with dermatitis or stomatitis related to the use of orthodontic appliances are described. All the patients were patch tested with the European standard series. One had a ++ reaction to potassium dichromate, one a ++ reaction to nickel, and the remaining 3 no positive patch tests. 3 of the patients had recurrent vesicular hand eczema, which flared after oral challenge with 1 of the metals used in their orthodontic appliances. 2 of these 3 patients had negative patch tests. The dermatitis of 4 of the 5 patients cleared completely upon the removal of their metal orthodontic appliances or their replacement with appliances made of acrylics.
 ...
PMID:Stomatitis or systemically-induced contact dermatitis from metal wire in orthodontic materials. 803 45

A 54-year-old woman patient had symptoms of stomatitis and asthma following the provision of a dental prosthesis in July 1991. We found a positive patch test reaction to palladium only, without any concomitant metallic contact dermatitis; in particular there was no sensitization to nickel. This is a very rare sensitization. After replacement of the dental alloy the clinical symptoms improved.
 ...
PMID:[Clinically relevant solitary palladium allergy]. 817 47


1 2 3 Next >>