Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunohistochemistry is finding an ever increasing application for electron microscopic diagnosis of human viral diseases. Certain progress has been made in the use of peroxidase-DAB/OsO4 as an electron-dense marker, and colloid gold. The paper discusses immunohistochemistry application for electron microscopic detection of such lymphotropic viruses as VSV (virus of vesicular stomatitis cultured in mink's lung cells), HTLV-1 (virus of human T4-cell C91Pl lymphoma culture) and HTLV-III/HIV-1 (virus growing in human T4-cell H9 culture).
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PMID:[Electron microscopic immunohistochemistry in the diagnosis of human lymphotropic viral diseases]. 290 47

The aim of the present study was to evaluate the immunomorphological characteristics of chronic recurrent ulcerative stomatitis. The patients were divided into 3 groups: 16 patients with mild, 15 patients with moderate, and 9 with severe stomatitis. The cytological smears were stained by Papanicolaou method. We have evaluated indexes of maturation (MI), keratinization (KI), destruction (DI), and inflammation-destruction (IDI). The immunocytochemistry was used to evaluate the local immune reactions. Anti-CD20 (pan-B marker), Anti-CD3 (pan-T marker), CD4 (marker of T helper), CD8 (marker of T cytotoxic lymphocytes) monoclonal antibodies were used (LSAB, DAB). The comparative analysis of cytological indexes in acute and remission phases of chronic recurrent ulcerative stomatitis showed that DI and IDI decreased in remission phase compared with acute phase, but did not return to norm. It seems that inflammation persists in remission phase despite the absence of symptomatic ulcerative lesion. In mild chronic recurrent ulcerative stomatitis the dynamic quantitative changes of immunocompetent cells in acute and remission phases show that the increased number of CD4+ T and CD20+ B lymphocytes has been found in remission phase indicating a persistent immune reaction and presence of non-eliminated pathogenic factors.
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PMID:[The immunomorphological characteristics of chronic recurrent ulcerative stomatitis]. 1583 78

The aim of the present study was to evaluate the immunomorphological characteristics of vesicular stomatitis. The patients were divided into 3 groups: 15 patients with mild stomatitis, 14 patients with moderate stomatitis, 11 patients with severe stomatitis. The cytological smears were stained by Papanicolaou method. We have evaluated indexes of maturation (MI), keratinisation (KI), destruction (DI) and inflammation-destruction (IDI). The immunocytochemistry was used to evaluate the local immune responses. Anti-CD20 (pan-B marker), Anti-CD3 (pan-T marker), CD4 (marker of T helper), CD8 (marker of T cytotoxic lymphocytes) monoclonal antibodies were used (LSAB, DAB). The comparative analysis of cytological indexes in acute and remission phases of chronic recurrent ulcerative stomatitis showed that DI and IDI decreased in remission phase compared with acute phase, but did not return to norm. It seems that inflammation persists in remission phase despite the absence of symptomatic vesicular lesion. Therefore, the evaluation of clinical efficacy of treatment requires assessing cytological indexes. In various types of vesicular stomatitis the dynamic quantitative changes of immunocompetent cells in acute and remission phases show the increased number of CD8+ T lymphocytes indicating a potential viral etiology and a persistent immunopathological reaction mediated by T cells. The presented data can be taken into account during the treatment planning and evaluation of therapeutic efficacy.
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PMID:[Immunomorphological characteristics of vesicular stomatitis]. 1585 97