Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Beclomethasone dipropionate (BDP) administered by inhaler is a very useful drug for the treatment of bronchial asthma. In this therapy, it is very important to use steroids systematically to induce a complete remission of asthma attack (first step) and then begin to use BDP a dose of more than 800 micrograms to maintain remission (second step). We treated 27 difficult asthmatics with this therapy and found this new method very useful. The characteristics of asthmatics were as follows. 1) The age ranged from 37 to 82, and the mean age (+/- S.E.) was 58.9 (+/- 2.6) years old. 2) The onset age ranged from 27 to 74 with a mean age (+/- S.E.) of 46.9 (+/- 2.6) year old. 3) The number of non-atopy was 22 cases. 4) The follow-up duration ranged from 5 to 45 months with a mean (+/- S.E.) of 15 (+/- 2.0) months. The results were as follows. 1) The complete remission rate was 48%, partial remission 37% and unchanged 15%. 2) There was a significant increase only in %VC. 3) The peripheral eosinophil count was decreased significantly. 4) The log value of PC20 concentration by acetylcholine increased significantly by a factor of 2.94 to 3.28. 5) After this therapy, the mean serum cortisol level at 9:00 a.m. was 10.1 (+/- 3.8, S.E.) micrograms/ml. There were only 2 cases whose cortisol level were under the normal. 6) There were many oral side effects, namely stomatitis with 5 cases and hoarseness with 8.
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PMID:[A new steroid therapy for difficult asthmatics--an induction and maintenance, two-step therapy]. 129 Apr 12

Most malignancies occurring in the oral cavity are squamous carcinoma for which radiotherapy as a treatment is the first choice. However, radiostomatitis, which occurs as a concomitant symptom due to radiation, largely disturbs the effect of radiotherapy. Antibiotics or a gargle are used to treat this concomitant symptom, but these preparations are not satisfactorily effective especially in cases in which the symptoms are severe and/or wide spread. Salcoat, a spray-type preparation of Beclomethasone dipropionate that is used to treat stomatitis, has excellent features which compensate for the disadvantage of the previously mentioned therapy. This preparation can be administered in a non-contact manner, and it contains hydroxypropyl cellulose which assures good adhesion to the mucosa, thus covering and protecting the affected area for a long time. In our clinical trials, this preparation was found to be highly useful in relieving pain and dysgeusia due to radiostomatitis, there by maintaining the quality of life.
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PMID:[Treatment of radiostomatitis with Salcoat]. 229 92