Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In my clinic, Solganal-B-Oleosum was administered to the patients with bronchial asthma from 1955 up to 1973, covering a period of 19 years, and statistical observation has been done. Several clinical results are presented. 1) In 1,056 cases, markedly improved 40.8%, improved 32.8%; clinically effective ratio: total 73.6%. Others: a few somewhat improved and unimproved cases, then inconsiderable aggravated cases. 2) The longer the period from the age of onset to the beginning of treatment, the lower the efficiency; the shorter the period, the higher the efficiency. 3) The group of light severity revealed high efficiency; and according to the grade of severity the efficiency decreased. 4) Sex, age, age of onset, disposition of asthma, etc., resulted in no clear relation to the effectiveness. 5) Side effect revealed 2.3% skin eruption, and then a few cases of proteinuria, stomatitis, gingivitis, etc. There was no case of severe, critical disorder. 6) In other cases, long-term effectiveness after finishing the Solganal treatment was pursued. A trial of additional injection for several years after finishing the treatment was also studied. Serum gold concentrations in the course and after finishing the main course etc., were measured.
J Asthma Res 1980 Jul
PMID:A few clinical statistical observations on the use of Solganal-B-Oleosum n bronchial asthma. 679 May 8

Herpes Simplex virus has been implicated as a cause of sporadic and recurrent erythema multiforme and Stevens-Johnson syndrome. Acyclovir has been used with success rates of 55% in treating these episodes. We have previously described and reported a successful management protocol for prevention of recurrent Stevens-Johnson syndrome due to herpes simplex virus reactivation in a 36-year-old white male. Four years later we describe the outcome of initiating this management protocol in the same patient for 17 episodes of recurrent herpes simplex virus stomatitis. Continuous low dose acyclovir with the prompt institution of a regimen of prednisone and higher dose acyclovir successfully prevented the prolonged duration of recurrent herpes simplex virus stomatitis and progression to Stevens-Johnson syndrome.
Allergy Asthma Proc
PMID:Recurrent Stevens-Johnson syndrome secondary to herpes simplex: a follow up on a successful management program. 893 96

Increasingly, physicians are being asked to evaluate patients with putative environmentally associated illnesses. These can include a variety of problems, including infectious illnesses (Legionnaire's disease), chemical exposure in the workplace, and sick building syndromes. The latter has been an issue particularly in asthma because of the association of mold and increased bronchial responsiveness. Recently, attention has been focused on the mold Stachybotrys in human disease. Stachybotrys was first identified more than 60 years ago following an epidemic of stomatitis, rhinitis, conjunctivitis, pancytopenia, neurologic disorders, and death in horses. Since then, Stachybotrys has been identified in several outbreaks of disease in animals. It has also attracted attention as a possible agent in idiopathic pulmonary hemorrhage in infants. Stachybotrys is a relatively uncommon fungus but has been isolated from a variety of sources, including contaminated grains, tobacco, indoor air, insulator foams, and water-damaged buildings with high humidity. This fungus is particularly important because it is one of a series of fungi that produces trichothecenes mycotoxins; these mycotoxins are biologically active and can produce a variety of physiological and pathologic changes in humans and animals, including modulation of inflammation and altered alveolar surfactant phospholipid concentrations. The presence of Stachybotrys in a building does not necessarily imply a cause-and-effect relationship with illness, but should alert physicians and healthcare professionals to do more vigorous environmental testing. Guidelines are presented herein for intervention measures in the maintenance of heating, ventilation, and air-conditioning systems.
J Asthma 2000 Apr
PMID:Sick building syndrome. III. Stachybotrys chartarum. 1080 8

Chediak - Higashi Syndrome (CHS) is a rare, primary Immunodeficiency disorder with an autosomal recessive (AR) inheritance and characterized by recurrent infection, partial occulocutaneous albinism and an accelerated phase.In this report we describe clinical and laboratory findings from 6 CHS patients. Clinical and laboratory information of six patients who were referred to our center during the last 20 years (from 1983 - 2003) were reviewed.Onset age of disease was between 3 months to 10 years. All patients had history of consanguineous parents and two patients were siblings. All patients had oculocutaneous albinism, nystagmus, recurrent infections which included upper and lower respiratory tract (U and LRT) infections, stomatitis, thrush, and skin abscesses and hepatitis. In laboratory findings, all patients had neutropenia and normal immunoglobulins and normal CD3, CD4, CD8 and CD19 lymphocyte by flowcytometry and three of the four patients had chemotatic defect. Five patients certainly had giant granule in bone marrow neutrophil and in one patient it was equiovocal. Three patients had an accelerated phase, and for one patient bone marrow transplantation was done that was tolerated well and had been well after 7 years.We emphasize the need for early diagnosis on basis of characteristic facies and diagnostic laboratory examinations and early bone marrow transplantation (BMT) in patients.
Iran J Allergy Asthma Immunol 2003 Dec
PMID:Report of six cases of chediak-higashi syndrome with regard to clinical and laboratory findings. 1730 79