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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using experimental models of candidal vaginitis in leukopenic mice and of stomatitis in neonatal animals, who developed the minimal inflammatory response, the author has defined the rate of invasive growth of C. albicans in mucosal stratified epithelium. Pseudomycelium was found to invade the epithelium at an average rate of 2 microns per hour, penetrating the entire epithelial lining within 24-48 hrs. These data have been extrapolated to a clinical condition. On the basis of measurements of mucosal epithelium thickness (carried out with autopsy and biopsy material), presumable periods of the total epithelium penetration were calculated; such penetration results in vascular invasion, thus making possible a disseminated involvement. These periods ranged from 22 to 59 hrs for different mucous membranes. Our findings demonstrate the significance of cellular and tissue defense reactions, which, if suppressed, may induce the fungi, normally found on epithelial surface as saprophytes, invade the host tissues and cause deep (and in some cases disseminated) mycotic involvement within several days.
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PMID:[The dynamics of the invasive growth of Candida albicans in the host's tissues]. 220 66