Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. A study amongst schoolboys in villages around Hyderabad, India, showed that almost all the boys had riboflavin deficiency, 61% had pyridoxine deficiency, and 9.4% had thiamin deficiency as judged by enzymic tests. 2. The prevalence of angular stomatitis was 41.3% and that of glossitis was 18.2%. Biochemical deficiency of riboflavin and pyridoxine was marginally higher in children with angular stomatitis with or without associated glossitis, than in children without oral lesions. 3. Treatment with B-complex vitamins (containing 4 mg riboflavin and 10 mg pyridoxine) daily for 1 month produced significant reduction in the prevalence of glossitis but had no effect on angular stomatitis. The latter responded to topical application of gentian violet. 4. Small but significant changes in erythrocyte enzymes occurred over the period of 1 month even without vitamin supplements. 5. Results suggest that while glossitis is a relatively early manifestation of riboflavin or pyridoxine deficiency or both, angular stomatitis has a more complex aetiology perphaps associated with infection.
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PMID:Relationship between biochemical and clinical indices of B-vitamin deficiency. A study in rural school boys. 46 34

The average riboflavin intake of 11 200 schoolchildren, aged 12-19 years, in Guangdong Province, China, was measured. Food intake was measured by weighing, and riboflavin intake was calculated by means of food tables. The average intake of riboflavin was 0.45 mg/day. In addition, clinical observations were made in 1313 adolescents in the dietary survey. The findings were consistent with the low intake of riboflavin. The observed clinical signs of riboflavin deficiency were scrotal dermatitis (7.9% of boys), angular stomatitis (5.8% of boys, 2.7% of girls), cheilosis (8.0% of boys, 5.6% of girls) and magenta tongue (36.0% of boys, 40.8% of girls). Corneal vascularization was found only in two of the 1313 children. Scrotal lesions resolved within three to six days after the oral administration of riboflavin (15 mg/day); the resolution of tongue and lip signs progressed more slowly.
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PMID:Riboflavin status of adolescents in southern China. Average intake of riboflavin and clinical findings. 649 12

In the diet of North American women, milk is by far the main source of Vitamin B2. The relationship of habitual dietary milk intake to riboflavin nutritional status in pregnancy is examined. The blood riboflavin values of 22 mothers, who by dietary history, took at least 1 glass of milk a day is compared with those of 12 with aversion. In the latter group, blood values of 8 mothers were suboptimum and 3 were deficient with angular stomatitis. In the former group, 2 were suboptimum and none were deficient. The blood riboflavin values of mothers and their prenates corresponded. Habitual diet poor in milk is a factor which may predispose North American women to Vitamin B2 deficiency in pregnancy. The concepts of cellular equilibrium and nutritional evolution are discussed.
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PMID:Milk, cellular equilibrium and nutritional evolution. 731 29

Three cases of clinical riboflavin deficiency are reported in children aged 2-10 years attending a regional Cystic Fibrosis clinic. Riboflavin deficiency presented as angular stomatitis in all three patients. Patients were confirmed to be riboflavin deficient by assaying the activity of erythrocyte glutathione reductase. Patients were not on routine supplements of water-soluble vitamins before presentation and were treated with riboflavin supplements as part of a water-soluble vitamin complex. At presentation, one patient had poor nutritional status, but two patients were adequately nourished, receiving overnight Gastrostomy feeds. Data on these two patients indicate an adequate dietary intake of riboflavin, suggesting a mechanism for increased requirements, inadequate absorption or utilization. Additional deficiencies of thiamin, pyridoxine and iron were also observed. This paper reports the occurrence of a vitamin deficiency not previously reported in the cystic fibrosis population.
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PMID:Riboflavin deficiency in cystic fibrosis: three case reports. 1190 77

Acute and chronic malnutrition and micronutrient deficiencies have been found in refugee camp populations. In southeastern Nepal, despite consistent access by refugees to general rations, certain micronutrient deficiencies have posed a substantial health burden to the approximately 100,000 Bhutanese residing in seven refugee camps. Limited food diversity, frequent illness, and poor feeding practices have been cited as underlying causes of poor nutritional status in this population. Annual surveys to assess levels of acute malnutrition (i.e., wasting) and chronic malnutrition (i.e., stunting) have been conducted in these camps by the Association of Medical Doctors of Asia (AMDA) and United Nations High Commissioner for Refugees (UNHCR); however, the capacity to reliably evaluate micronutrient deficiencies has not existed locally in the camps. In January 2007, AMDA and CDC, at the request of UNHCR and the World Food Programme (WFP), conducted a nutritional survey of children aged 6-59 months, assessing 1) the prevalence of acute malnutrition, chronic malnutrition, underweight, anemia, and angular stomatitis (i.e., riboflavin deficiency); 2) the cumulative incidence of diarrhea and acute respiratory illness (ARI); and 3) the feeding practices of the children's mothers. This report describes the results of that survey, which indicated that, although acute malnutrition was found in only 4.2% of the children, chronic malnutrition was found in 26.9% and anemia in 43.3%. These findings underscore the importance of monitoring both malnutrition and micronutrient deficiencies and addressing the underlying causes of nutritional deficits.
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PMID:Malnutrition and micronutrient deficiencies among Bhutanese refugee children--Nepal, 2007. 1840 31