Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An attempt has been made to classify ground waters in various districts of Rajasthan based on distribution of nitrate in their drinking water samples. It is seen that nitrate in ground water is unevenly distributed in the state. Major parts of Churu, Alwar, Bharatpur, Jalore, Jaipur, Sikar, Tonk and Jhunjhunu, are inherited by nitrate rich ground waters while districts like Banswara, Bundi, Bikaner, Chittor, Kota and Jhalawar have low nitrates in their ground waters at many places. It is well documented internationally that water supplied containing high levels of nitrate have been responsible for cases of infantile methemoglobinemia which may ultimately lead to death. A very high infant mortality rate in Rajasthan might be a consequence of high nitrates in drinking water supply. Some recent studies have shown that nitrates in drinking water besides causing methemoglobinemia can result in various other clinical manifestations like recurrent stomatitis, recurrent respiratory tract infections (RRTI) etc. These findings have indicated that a rethinking has to be given to the existing standards for nitrates in drinking water. Based on potential nitrate toxicity studies in view of above health effects the whole region has been classified into five water quality zones, namely, safe, mild, moderately problematic, highly problematic and dangerous. For areas falling under fourth and fifth zones it is recommended that immediate measures be taken to overcome the adverse health effects.
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PMID:Need for revision of nitrates standards for drinking water: a case study of Rajasthan. 1450 89

Methemoglobinemia is a rare congenital or acquired disease of increased blood methemoglobin concentration. We documented 2 cases of children suffering from neuroblastoma whose postchemotherapy anemia, leucopenia, and stomatitis were complicated by methemoglobinemia after using a formulary oral gel (7.5% benzocaine, doxycycline, nystatin, glycerin). The complication resulted in hospital treatment. Percutaneous oxygen saturation remained at 85% and 87% despite administration of 100% oxygen through a nonrebreather mask. Arterial blood gas analysis showed an oxygen saturation of 98% and 97%, respectively. Spectroscopic measurement showed methemoglobin concentration of 42% and 35.5%, respectively. After red blood cell transfusion and oral ascorbic acid in case 1 and methylene blue in case 2, the patients' condition improved. Although the benzocaine gel is not in use in several medical systems, it should be considered as a possible reason for methemoglobinemia.
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PMID:Methemoglobinemia in postchemotherapy stomatitis topical treatment: 2 pediatric cases. 2190 Aug 33