Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neutralization tests with a strain (BA) of Allerton-type herpes virus, derived from a buffalo (Syncerus caffer) were carried out on 924 sera from 17 species of E. African game animals and on cattle sera from Tanzania (2001), Kenya (792) and Uganda (410).Buffalo populations throughout E. Africa showed a very high rate of infection, with all animals over 2 years of age serologically positive. Antibody was present in some giraffe, waterbuck and hippopotamus sera and, less frequently, in impala, eland, bushbuck and oryx. Data are provided on the titres of positive samples; the mean titre of buffalo sera increased with age.Cattle in many localities of N. Tanzania and S. Kenya showed a very high rate of infection, 85-95% of sera from animals more than 2-years old containing antibody; the titres recorded were lower than those in buffaloes. Very high infection rates were also found in Karamoja and Teso (Uganda) and also in some other areas of Kenya, whilst a considerably lower incidence of infection was detected in W. Nile Province of Uganda and in central Tanzania. Differences in infection rates may have been related to herd size and husbandry practices.It was shown that a wave of infection was probably spreading through cattle in N. Tanzania at about the same time as an outbreak of disease occurred in buffaloes and it is suggested that virus transmission may have been by biting flies.No clinical signs attributable to the virus were reported in cattle but mouth lesions similar to those recorded in buffaloes, or nasal lesions, could have passed undetected. Allerton-type virus probably produces a range of clinical syndromes in cattle, closely resembling those associated with some herpes viruses in primates but infection is seldom related in the field to either pseudo-lumpy skin disease, mammillitis or stomatitis.
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PMID:Investigations of Allerton-type herpes virus infection in East African game animals and cattle. 432 48

Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza A(O), A(2), and B viruses and parainfluenza 1 virus. infections is also effective.
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PMID:Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. 434 Sep 49

Specimens of mixed untreated saliva from 3 groups of children were tested for antibodies to herpes virus by the fluorescent antibody technique (33 children with acute herpes stomatitis, 64 with recurrent herpes stomatitis, and 30 in the control group). Herpes virus antibodies were found in the saliva in 27.2 +/- 7.7% of the cases at the peak of acute stomatitis and in 77.7 +/- 10.0% of cases in the period of epithelization, in 84.6 +/- 10.0% of the examined subjects the antibodies were detected 2-4 months after the disease. Examinations of 64 saliva specimens obtained from the children during one of the relapses of chronic stomatitis demonstrated antibodies more frequently (59.3 +/- 8.0%) than in children at the peak of acute stomatitis disease. A trend for increased antibody content in the saliva of children by the period of epithelization of lesions in the buccal cavity both in acute stomatitis and during relapses of chronic disease was observed. No herpes antibodies were found in saliva specimens from 30 children of the control group.
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PMID:[Detection of specific local immunity factors in children with herpetic diseases of the oral mucosa]. 609 45

A total of 9 calves were used to test the interferon-inducing activity of strain Vulchedrum of the bovid Herpes virus 1. The virus of stomatitis vesiculosa adapted to cell cultures of calf kidney was used as an indicator of interferon. The antiviral action of interferon was demonstrated in the serum and the nose discharge of calves. The dynamics of interferon production in calves varied, depending on the venous, muscular, and tracheal route of application of the virus. Highest interferon titer in the serum was established at the venous application. In the nose discharge highest titers were found following tracheal application. Additional criteria demonstrating the presence of interferon in the positive serum and discharge samples were the unchanged activity at pH 2 and 4 degrees C for 24 hours; the unchanged activity following heating at 56 degrees C for 30 min; the unchanged activity following treatment with ether; the lack of activity following heating at 25 degrees C for 30 min; and the lack of activity at incubation with trypsin. The positive samples showed also antiviral unspecificity--inhibited was not only the virus of stomatitis vesiculosa, but also M. parainfluenza-3.
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PMID:[Interferon induction in calves after experimental infection with bovine herpesvirus 1]. 618 69

The antiviral activity of interferon was shown to be dependent on the input m.o.i. Cells could not be protected against the cytopathogenic effect of vaccinia, herpes, Echo or vesicular stomatitis virus at m.o.i. greater than 1. At a m.o.i. of less than or equal to 1, cells could be protected but the amount of interferon necessary to yield protection was inversely related to the m.o.i. When protection was afforded, it was only transient. The duration of the antiviral effect of interferon was also inversely related to the m.o.i. The dependence of the antiviral effect on the m.o.i. could not be explained by assuming the viruses to be mixtures of subtypes with different interferon sensitivity. Also, selection by interferon treatment of interferon-insensitive subtypes could not be shown. The greater antiviral effect of interferon at low m.o.i. was probably not caused by induction of interferon by the infecting virus. A direct inactivation by the virus of the antiviral effect of interferon could not be demonstrated. These results indicate that when interferon-treated cells are infected, they will not survive the infection. The only result of the interferon treatment will be to inhibit virus replication to some extent, leading only to a delay in cell death.
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PMID:Influence of input multiplicity of infection on the antiviral activity of interferon. 624 42

Little is known of the occurrence of animal virus diseases in the Sultanate of Oman. This paper reports the results of a countrywide survey carried out in 1978 to establish the prevalence of some important viral pathogens of domestic animals with the dual purpose of providing baselines for future investigations and guidelines for those entrusted with disease control. Foot-and-mouth disease virus type O, previously identified in Oman in 1976, was isolated from clinically affected animals. In addition, virus types A and Asia 1 were isolated from unaffected animals. Serological studies indicated that infection with all 3 types had been widespread. The presence of infectious bovine rhinotracheitis was confirmed by virus isolations and sheep and goat pox, long recognised in Oman, was confirmed by the demonstration of pox particles in dried lesion material. In serological studies antibodies were found to the viruses of peste des petits ruminants, bovine herpes mammillitis, bovine virus diarrhoea, parainfluenza 3 and African horse sickness. There were no significant antibody levels to rinderpest in unvaccinated animals and no antibody to equine infectious anaemia or vesicular stomatitis viruses.
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PMID:Some virus diseases of domestic animals in the Sultanate of Oman. 625 86

In view of the fact that bis cyclopentadienyl metal dihalides are known to be anti-tumour drugs, we have investigated the antiviral activity of this type of coordination compounds. Bis cyclopentadienyl titanium dichloride (a) has shown significant antiviral efficiency in vitro against representatives of a nuber of enveloped DNA and RNA viruses. Inhibition of orthopoxvirus (vaccinia), herpes virus (pseudorabies), orthomyxoviruses (influenza A/fowl plague [FPV], influenza A/Victoria 3/75, influenza A/jena 48/78 and influenza B/Johannesburg), paramyxovirus (Newcastle disease [NDV]) and rhabdovirus (vesicular stomatitis [VSV]) was observed after direct contact with the compound under loss of infectivity up to 100%. Regarding the group of unenveloped viruses only adenovirus type 4 became influenced but not type 5. No antiviral activity could be found against the cardiovirus Mengo. The compound bis cyclopentadienyl molybdenum dichloride failed to show an antiviral action versus vaccinia, influenza A/FPV and influenza viruses B/Johannesburg. Application of the inhibitor (a) during the replication of vaccinia and influenza viruses A/FPV in cell cultures produced an additional effect of inhibition of virus multiplication. On the other hand, adenovirus type 4 and VSV replication was not affected by titanocene dichloride.
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PMID:[On the biological action of transition metal complexes. 4. The antiviral activity of metallocene dichlorides of titanium and molybdenum (author's transl)]. 627 97

Immunofluorescent examination of blood smears from 155 children aged from 1 to 11 years with manifestations of herpetic infection in the oral cavity (primary acute stomatitis diagnosed in 108, recurrent in 47) was carried out. Antigens of herpes virus in blood leukocytes from sick children were detected in 50.9 +/- 4.8% of cases of acute stomatitis and in 51.0 +/- 7.3% of cases in the period of exacerbation of chronic stomatitis. Herpes virus antigens were detected significantly more frequently in the specimens obtained in the febrile period and in those collected during the first 3 days of the disease or relapse. Examinations of 30 children of the control group yielded herpes virus antigen in 1 case only.
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PMID:[Detection of viremia in children with manifestations of an oral herpes infection]. 631 72

The investigations have been carried out concerning the effectiveness of compound ITCl p-chlorophenylamide of 3-methyl-5-benzoylaminoizothiazole-4-carboxylic acid in the therapy of experimental, virus keratitis. Changes occurring on the cornea were morphologically determined and the intensity of the reaction, which per continuitatem penetrates deeper parts of the anterior eye chamber was estimated in the aqueous humor, applying biochemical factors. It has been stated that the drug in question, when applied locally, significantly weakens keratitis caused by herpes virus or by vesicular stomatitis virus. It limits the expansion of the inflammatory reaction, accelerates the reparation processes of the cornea, and causes the reparation changes not to damage the cornea optical transparence or renders the damage weaker. The conclusion has been drawn that the therapeutic effect of the drug is due to its antiviral and anti-inflammatory effect which has been revealed before.
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PMID:Investigations on the activity of p-chlorophenylamide of 3-methyl-5-benzoylaminoisothiazole-4-carboxylic acid (ITCL) in the experimental keratitis. 632 6

The toxic effects of high-dose busulfan (16 mg/kg) and cyclophosphamide (200 mg/kg) with autologous or syngeneic bone marrow rescue were evaluated in 19 patients (11 with acute myelocytic leukemia, one with acute lymphocytic leukemia, one with acute myelofibrosis, two with chronic myelocytic leukemia, one with Hodgkin's disease, and three with non-Hodgkin's lymphoma). Their mean age was 26 years (range, 6-50); nine patients had syngeneic and ten had autologous bone marrow rescue (six of whom had in vitro bone marrow incubation with 4-hydroperoxycyclophosphamide). Severe myelosuppression was expected and was seen in all patients; leukocyte and platelet count recovery occurred at a median of 19 days (range, 11-59) and 30 days (range, 20-89), respectively. Nausea, vomiting, and diarrhea were frequent but readily managed with vigorous medical therapy. Stomatitis was severe in 14 patients. Skin, renal, cardiac, pulmonary, and CNS complications directly attributable to drug-related toxic effects were transient and non-life-threatening. Hepatic function abnormalities were common but tended to be transient. Most patients tolerated high-dose busulfan and cyclophosphamide with manageable side effects. Hepatic veno-occlusive disease was fatal in two patients, while diffuse interstitial pneumonitis with disseminated herpes virus infection was fatal in three patients with lymphoma. All patients treated in relapse or without previous therapy had a complete tumor response. Further studies with this regimen should be pursued.
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PMID:Preliminary results of high-dose busulfan and cyclophosphamide with syngeneic or autologous bone marrow rescue. 637 4


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