Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Desquamative gingivitis is characterized by a diffuse erythema of the marginal and attached gingivae associated with areas of vesiculation, erosion, and desquamation. Desquamative gingivitis is not a disease sui generis but represents a reaction pattern of the gingivae to various stimuli. Cicatricial pemphigoid, lichen planus, and pemphigus vulgaris may present as desquamative gingivitis. We observed forty-one patients whose disease was limited to the gingiva; studied them by light and direct immunofluorescence microscopy; classified them according to clinical, histologic, and immunopathologic observations; and followed them for an average of 3 years. Two patients had pemphigus vulgaris, and one each had lichen planus and contact stomatitis. Thirty-seven were classified as cicatricial pemphigoid suspects. In eighteen patients, the gingivitis developed into cicatricial pemphigoid, and in nineteen, it remained limited to the masticatory mucosa. Disease evolution is slow. The response to anti-inflammatory therapy, including topical corticosteroids and systemic dapsone or sulfapyridine, has been gratifying.
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PMID:Desquamative gingivitis: clinical, histopathologic, immunopathologic, and therapeutic observations. 675 83

Desquamative gingivitis is a fairly common complaint. Typically seen in females who are middle-aged or older, it is predominantly a manifestation of a range of vesiculobullous disorders. The main complaint is of persistent soreness of the gingiva. Most cases are related to lichen planus or pemphigoid, but it is also important to exclude pemphigus, dermatitis herpetiformis, linear IgA disease, chronic ulcerative stomatitis, and other conditions. Biopsy is invariably required to confirm the diagnosis after a full history, general, and oral examination. Apart from improving the oral hygiene, immunosuppressive therapy is typically required to control the condition.
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PMID:The clinical spectrum of desquamative gingivitis. 942 Dec 23