Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between September 1976 and May 1989, 12 cases of uveitis attributed to the systemic use of sulfonamide derivatives were reported to the National Registry of Drug-Induced Ocular Side Effects and the US Food and Drug Administration. We evaluated these reports in addition to one case previously reported in the literature and one patient seen at the Uveitis Clinic, Oregon Health Sciences University, Portland. The patients' median age was 34 years. Twelve of 14 patients were treated with trimethoprim-sulfamethoxazole. All patients for whom the location of the eye disease was specified presented with an iritis. Six reports included a description of ocular symmetry, with all patients having bilateral inflammation. Of the nine patients for whom data on the duration of drug use was available, seven experienced adverse effects within 8 days of beginning trimethoprim-sulfamethoxazole therapy and four showed effects within 24 hours. Three patients had histories of rechallenge with trimethoprim-sulfamethoxazole, and in each case acute iritis recurred within 24 hours of reinstitution of therapy. Five patients had additional evidence of an adverse reaction manifested as Stevens-Johnson syndrome, erythema multiforme, diffuse macular or vesicular rashes, stomatitis, glossitis, conjunctival and scleral injection, and granulomatous hepatitis. The consistent presentation including bilateral, anterior inflammation and the recurrence with rechallenge strongly indicate a cause-effect relationship. Although uveitis secondary to sulfonamides is a rarely diagnosed clinical event, recognition of the distinct presentation of this entity is important in the differential diagnosis of uveitis.
 ...
PMID:Systemic sulfonamides as a cause of bilateral, anterior uveitis. 178 69

Behcet's disease is a systemic inflammatory disease of unknown etiology which usually occurs as a trait of symptoms: aphatous stomatitis, genital ulcerations and eye disease. Characteristic manifestations are frequent: erythema nodosum, arthralgias, arthritis, myalgias, phlebothrombosis and nervous system disorders as well as disorders of other organs and systems. Behcet's disease was discovered in 1937 for the first time by dermatovenerologist Hulusi Behcet (1889 - 1948) after whom it was named Behcet's disease or Behcet's syndrome. At the beginning of the disease the diagnosis is uncertain because of different schedule of certain manifestations and a long period up to the full clinical picture manifestation. As it is well known, the main changes occur at the buccal mucosa in a form of a recidivant aphthous and herpetiformis lesions. Genital ulcerations are present in 64 to 87% of patients. Changes which occur on eyes may be present in 28 - 80% of patients and may dominate the clinical picture. The skin is affected in about 50% of patients. Manifestations on joints occur at major joints of the lower limbs. Sometimes gastrointestinal manifestations occur as enterocolitis and ulcerous colitis. Nervous system lesions have poor prognosis. The treatment involves: acute exacerbations with multisystemic manifestations by utilization of non-steroid anti-inflammatory drugs and immunosuppressive preparations. Corticosteroids are used in severe cases.
 ...
PMID:[Behcet's disease--clinical picture and treatment]. 869 3