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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Denture plaque is an etiologic factor in denture stomatitis. In this study, denture and mucosa samples from nine patients were examined in the SEM and processed for microbiologic cultures. Denture plaque in patients with denture stomatitis showed a considerable thickness containing cocci, filaments, rods, yeasts, and desquamated epithelial cells. Some microorganisms were revealed in the connective tissue in one patient and phagocytizing polymorphonuclear leukocytes were found in the palatal mucosa of the patients with denture stomatitis.
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PMID:Denture plaque and palatal mucosa in denture stomatitis: scanning electron microscopic and microbiologic study. 329 27

A purine analogue, 2-aminopurine, reported to act as an inhibitor of protein kinase, selectively, reversibly and in a dose-dependent manner blocked a very early stage in interferon induction. With chick embryo cells and mouse L cells as hosts, and different viral inducers of interferon, maximal effects of 2-aminopurine were observed during the first 4 h of induction. At 10 mM-2-aminopurine there was a 20-fold reduction in the yield of interferon from both cell types. 2-Aminopurine and actinomycin D both prevented interferon induction with the same time course, indicating a transcriptional block to induction; however, only the action of the former was reversed upon removal of the drug. Addition of 2-aminopurine to an agarose overlay resulted in high efficiency plaque formation by vesicular stomatitis virus New Jersey (Hazelhurst) under conditions where endogenous induction of interferon and its feedback action on aged chick embryo cells normally prevented plaque formation. Two other inducible systems, representing genes involved in interferon action (both its development and activation), and those of heat shock, were not affected by 2-aminopurine. A model is presented implicating the interferon-inducible dsRNA-dependent protein kinase as an interferon induction receptor which, on interaction with dsRNA, generates an amplified signal via phosphorylation that ultimately derepresses the interferon gene(s).
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PMID:Interferon induction by viruses. XVI. 2-Aminopurine blocks selectively and reversibly an early stage in interferon induction. 339 21

Using special acrylic discs glued into the palatal surface of a denture the development of denture plaque in a case of denture stomatitis as well as the relationships between the denture surface, pellicle, plaque and palatal epithelium were studied with transmission electron microscopy after 30 mn, 1 h, 4 h, 8 h, 24 h, 48 h, 9 days and 29 days. A thin pellicle which increased in thickness from 9 hours to 28 days was visible at the surface of the acrylic denture. It appeared that bacteria retained in the palatal epithelial intercellular spaces were the source of the plaque which developed at the surface of the acrylic denture. Initially loosely packed cocci-like and a few rod-shaped Gram positive bacteria appeared in 8 hours samples at the denture-epithelium interface. An important increase in denture plaque thickness was noted between 24 and 48 hours. In 9 and 28 days samples, coccoid and rod-shaped Gram positive and Gram negative bacteria were present and filamentous bacteria began to be apparent. In all the samples studied, Candida was rare.
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PMID:Ultrastructural development of dated plaque in case of denture stomatitis. 346 Sep 89

The clinical and pathological study was performed in order to determine the histopathological and cytoimmunological characteristics of denture stomatitis. All specimens were biopsy materials from seventeen patients with denture stomatitis. Normal palatal mucosae from ten patients served as the control. In addition to the usual staining methods, naphtol AS-D chloroacetate esterase stain and peroxidase-antiperoxidase method were used to detect mast cells and plasma cells. Denture stomatitis could be divided into atrophic and hyperplastic types. The former showed a smooth and atrophic mucosa. The latter showed a large number of exophytic projections which were composed of marked acanthosis and submucosal fibrosis, and was further subdivided into granular and papillary subtype according to the size of projections. In the present study, there were six cases of the atrophic type, and eleven cases of the hyperplastic type (consisting of seven granular and four papillary subtypes). The hyperplastic type was more frequently observed in patients with partial dentures compared with complete dentures and was associated frequently with ill fitting of the denture base as well as agglutination of denture plaque. Cytoimmunological study revealed that there was a pronounced increase of plasma cells, especially IgG- and IgA-producing cells, and a moderate increase of lymphocytes as well as mast cells in both types of denture stomatitis. Mast cells were always noted in the area with marked plasma cell infiltration, suggesting an intimate relation between both cells. These findings suggest that the immunological reactions play some role in the pathogenesis of denture stomatitis.
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PMID:Clinico-pathological study on denture stomatitis. 348 90

Control of denture plaque accumulation is essential to obtain and maintain a healthy oral mucosa in denture wearers. The present study was designed to study the effect on denture plaque accumulation and denture stomatitis of coating the fitting denture surface by a glaze. Twenty-one subjects wearing complete dentures participated in the study. Glazing of the denture surface was performed using a Perma Cure System. Plaque accumulation was studied clinically and using a semiquantitative microbiologic technique. Plaque accumulation on the glazed and the non-glazed halves of the fitting denture surface was compared after 1 wk. There was significantly less plaque on the glazed half of the denture (P less than 0.001), and the calculated number of CFU of bacteria/cm2 was significantly lower from the test area of the glazed half than from the test area of the non-glazed half of the denture (P less than 0.001). When the patients were re-examined 1 month after the entire fitting denture surface had been glazed plaque scores, yeast scores and number of CFU of bacteria/cm2 were not significantly different from those observed before glazing. There was a reduction of the erythema of the palatal mucosa in 14/19 patients with denture-induced stomatitis. The study indicates that coating of the fitting denture surface by a glaze may be a means to improve denture cleanliness; however, the present glazing system should be further developed to produce a more uniform glazing.
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PMID:Clinical effects of glazing denture acrylic resin bases using an ultraviolet curing method. 354 79

The purpose of the present study was to examine the relation between oral hygiene habits, denture plaque, presence of yeasts and stomatitis in institutionalised elderly. A sample of 201 residents, 48-99 yr of age (mean age 82 yr), was selected from four different institutions in Lothian, Scotland. Clinical recordings were carried out under standardised circumstances using well recognised indices. Information about oral hygiene habits was obtained through structured interviews conducted immediately before the clinical examination. A multivariate analysis, principal component, was carried out on the correlated five maxillary denture plaque scores and two components, accounting for 74% and 12% of the variation, were identified. Using these two independent variables, an analysis of variance was carried out testing for significance between the four effects: soaking habits, brushing habits, denture stomatitis and growth of yeasts in the palate together with their interactions. The analysis showed a significant relation between maxillary denture plaque, soaking habits and the presence of denture stomatitis. There was no relation between denture plaque and brushing habits or between denture plaque and growth of yeasts.
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PMID:Oral hygiene habits, denture plaque, presence of yeasts and stomatitis in institutionalised elderly in Lothian, Scotland. 355 96

A cytotoxic factor was induced by the injection of LPS into the peritoneal fluids of mice which had been previously primed with a streptococcal antitumor preparation, OK-432. No cytotoxic effect on L-929 cells was observed in the peritoneal fluids of mice singly treated with OK-432 or LPS. Various mouse and human tumor cell lines were effectively killed by this peritoneal cytotoxic factor, though normal cell lines were insensitive, which indicates that this factor is not species-specific. The highest level of cytotoxic activity was obtained when LPS was given to mice 5 days after the injection of OK-432. The optimal time for collection of peritoneal fluids for the cytotoxic factor was 2h following the LPS injection. Interferon activity was found to be negative by the plaque reduction test using L-929 cells with vesicular stomatitis virus.
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PMID:[Production of a cytotoxic factor in mouse peritoneal fluid by OK-432, a streptococcal preparation]. 370 50

Mouse L-A9 cell interferon was induced by infection with Newcastle disease virus. Interferon production was 1.5 X 10(5) IU/10(7) cells. Interferon was partially purified by precipitation with ammonium sulphate, chromatography on CM-Sephadex and hydrophobic chromatography on octyl-agarose. The specific activity of the final preparation was 1.7 X 10(7) IU/mg protein. Treatment of L-A9 cells with 20 IU/ml interferon prior to viral infection inhibited the intracellular accumulation of reovirus-specific double-stranded RNA. Dose-response studies of the cells to interferon indicated that L-A9 cells require 10, 13 and 15 IU/ml to obtain 50% viral plaque reduction for Marituba virus, vesicular stomatitis virus and reovirus, respectively. The present results demonstrate the potential of mouse L-A9 cells as an interferon-producing system and also as a model for the study of the effect of cellular response to exogenous interferon treatment on the replication of RNA viruses.
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PMID:Interferon induction in mouse fibroblast L-A9 cells. 383 78

The relationship between denture base plaque and mucosal inflammation under complete dentures was tested by clinical comparison with the PTI and a comparable plaque-scoring technique. Two treatment groups, one of which practiced tissue-brushing only and the other denture-brushing only, were compared with a control group with regard to mucosal inflammation and denture plaque score. Significant reduction in inflammation occurred, although no reduction in denture base plaque score was found. The effect of denture plaque on denture stomatitis and the efficacy of denture-brushing as a plaque removal technique is challenged.
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PMID:Denture plaque control and inflammation in the edentulous patient. 386 Jun 60

Denture pellicle in denture stomatitis has been studied with transmission electron microscopy after embedding the denture base in a water-miscible resin in seven patients with heavy plaque deposits on their dentures and in five patients with no apparent plaque accumulation. In the first group, the denture surface was covered by a well differentiated granular pellicle. A cell-free zone was interposed between the pellicle and the plaque, which consisted predominantly of rounded, rod-shaped, and filamentous microorganisms with a loose distribution, separated by an electron-lucent amorphous and gel-like matrix. C. albicans were scattered among the bacteria and often presented with degenerated cytoplasm. In the second group, a structurally heterogeneous pellicle was seen adjacent to the denture surface. A thin plaque that consisted mainly of dense accumulations of C. albicans, a narrow dense matrix, and few bacteria was found. Calculus accumulations on the dentures consisted of amicrobial calcifications in the deeper layers, whereas the superficial parts showed bacterial calcifications.
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PMID:Transmission electron microscopy of plaque accumulations in denture stomatitis. 388 38


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