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Query: UMLS:C0038362 (stomatitis)
 8,852 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study evaluated the effect of an antimicrobial mouthrinse, denture soft relines, and a placebo rinse on the clinical findings and microbial flora of 78 patients with denture stomatitis. For 28 days the study and control groups performed oral rinses and denture soaks. Reline group patients had maxillary denture soft relines that were changed every 7 days. At the end of the study, the mean severity of denture stomatitis was significantly less in the groups that used the study rinse (P less than 0.01) and received denture relines (P less than 0.05) compared to the control. Analysis of variance revealed significant differences in ranked adjusted percentage counts in two out of 13 denture plaque organisms investigated (Fusobacterium nucleatum [P less than 0.05] and total Bacteroides [P less than 0.05]), with the antiseptic rinse producing the lowest count. Yeast populations were reduced, but not significantly (P = 0.07). In the absence of other mechanical denture hygiene procedures, the antiseptic rinse and relines were equally effective in reducing denture stomatitis and potential pathogens of denture plaque flora.
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PMID:Clinical and microbial evaluation of treatment regimens to reduce denture stomatitis. 208 73

The appliance hygiene performance and its relationship with stomatitis lesions were investigated on 124 patients who were using maxillary removable orthodontic appliance. The patients were divided into five groups according to the appliance wearing periods. Appliance hygiene index (AHI) showed no significant difference between the groups except the fifth group and the prevalence of stomatitis was found as 8.9 percent. There was not any significant correlation between the quantity of plaque and the degree of stomatitis.
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PMID:[An evaluation of appliance hygiene index on patients wearing removable orthodontic appliance]. 210 44

Three strains of human coronavirus (HCV) OC43 were compared for their ability to cause enteric infections and to induce interferon alpha (IFN alpha) using the Caco-2 human colon carcinoma cell line which exhibits spontaneous epithelial differentiation in vitro. MRC-5 cell culture grown stocks were prepared from: 1. CV Paris, a strain of OC43 recovered from an outbreak of necrotizing enterocolitis in newborns. 2. CV Mb, a neurotropic strain of OC43 which exhibits strict neuronal specificity in murine neuronal cell cultures. 3. CV Rd, a strain of OC43 which grows to a high titer in human rhabdomyosarcoma (RD) cells. Immunofluorescent staining for nucleocapsid antigen and plaque assay in MRC-5 cells was used to detect viral replication. BG-9 (human foreskin) cells challenged with vesicular stomatitis virus were used to detect IFN alpha production by human peripheral blood monocytes (PBMC) stimulated by virus infected Caco-2 cells. Caco-2 cells infected with virus at a multiplicity of infection of 0.5 yielded 10(4.6) and 10(4.4) plaque forming units/ml (pfu/ml) with CV Rd and CV Paris respectively, while CV Mb yielded only 10(3) pfu/ml. Caco-2 cells infected with CV Rd induced 64 IU/ml of IFN alpha in PBMC while these cells infected with CV Paris induced less than 2 IU/ml IFN alpha. In cells infected with CV Mb 4 IU/ml IFN alpha was detected. The results suggest that a lack of IFN alpha induction by CV Paris may be an indicator of its enteropathogenic potential.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Comparison of the replication of distinct strains of human coronavirus OC43 in organotypic human colon cells (Caco-2) and mouse intestine. 210 2

A previous study suggested that denture plaque played an etiologic role in denture stomatitis. In daily practice, it is important to instruct denture wearers about denture plaque control. In this study, the major areas of investigation were the degree of denture stomatitis and denture plaque, denture hygiene habits, wearing habits and age of present denture. 643 patients wearing dentures (1981-1988) were selected, from 47 to 91 years old. The following results were obtained. 1. About 50 percent of the 643 patients used brush for cleaning their dentures. The number of people wearing dentures during sleep was fewer than those who preferred removal of dentures during sleep. 2. Soaking dentures in denture cleanser reduced the degree of denture stomatitis and denture plaque. 3. The patients wearing dentures during sleep showed much more occurrence of denture stomatitis than those who had not that habit. 4. Denture stomatitis occurred frequently with increasing the age of the present denture. The present results indicate that the occurrence of denture stomatitis is closely related to the quality of the maintenance of denture.
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PMID:[Clinical survey on denture stomatitis. 2. The relation between the maintenance of denture and denture stomatitis]. 213 23

The purpose of this study was to investigate the influence of tongue brushing on the change of oral Candida species. Among the tongue brushing programs for 50 days, 5 subjects wearing dentures were measured the number of Candida species at tongue, denture and denture bearing mucosa and in oral rinsing. The following results were obtained. 1. After the tongue brushing program, the number of Candida species at tongue and in oral rinsing decreased significantly. 2. The tongue brushing with denture plaque control decreased in number of Candida species at denture more effectively than without denture plaque control. 3. The number of Candida species at denture bearing mucosa decreased by tongue brushing. 4. It seemed that the tongue brushing was effective to prevent denture stomatitis caused by denture plaque.
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PMID:[Change of number of oral Candida species by tongue brushing]. 213 24

We previously demonstrated that dexamethasone treatment of L929 cells inhibited plaque formation by vesicular stomatitis virus (VSV), encephalomyocarditis virus, or vaccinia virus. We now have characterized the antiviral effects of glucocorticoids in L929 cells. Dexamethasone did not directly inactivate VSV nor did steroid treatment of L929 cells affect virion adsorption or penetration. The VSV yield in L929 cells treated with dexamethasone for a period of only 4 or 8 hr was decreased by 50% when cells were infected the day following steroid treatment. Treating L929 cells with dexamethasone for a longer period resulted in greater inhibitions of virus synthesis. Interferon activity (less than 5 units/ml) was not detected in L929 cell culture fluids and cell sonicates from steroid-treated cells and the addition of antiserum to murine alpha/beta-interferon had no effect on the ability of dexamethasone to inhibit VSV replication. Dexamethasone treatment of L929 cells did not induce the production of double-stranded RNA-dependent protein kinase but did result in a slight elevation of 2-5A oligoadenylate synthetase activity, two enzymatic activities associated with the antiviral state induced by interferon. However, the elevated 2-5A synthetase activity was not associated with an inhibition of VSV RNA accumulation in dexamethasone-treated L929 cells. By contrast, the synthesis of all five VSV proteins was reduced by 50-75% in dexamethasone-treated L929 cells as early as 4 hr after infection. Thus, the dexamethasone-mediated inhibition of VSV replication in L929 cells is associated with decreased production of VSV structural proteins.
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PMID:Inhibition of vesicular stomatitis virus replication in dexamethasone-treated L929 cells. 215 55

Laboratory-reared female sand flies (Lutzomyia shannoni) were experimentally infected, orally and by intrathoracic inoculation, with the New Jersey serotype of vesicular stomatitis (VSNJ) virus. Virus replication occurred in the insects following infection by both routes. Virus titers greater than 10(4) plaque forming units of VSNJ virus were present in heads of orally infected sand flies 12 days after virus ingestion, confirming that a persistent disseminated infection had occurred. Both orally and parenterally infected Lu. shannoni transmitted VSNJ virus by bite to susceptible rodents and by transovarial transmission to a small percentage of their F1 progeny. The significance of these findings in the epizootiology of VSNJ virus on Ossabaw Island, Georgia, an enzootic focus of this virus, is discussed.
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PMID:Vesicular stomatitis virus, New Jersey serotype: replication in and transmission by Lutzomyia shannoni (Diptera: Psychodidae). 216 Jan 98

A 100 plaque forming unit (pfu) dose of a temperature-sensitive (ts) mutant of vesicular stomatitis virus (VSV), tsG31 KS5, engendered a slowly progressive paralytic central nervous system (CNS) disease that killed all BALB/c nude mice within 28 days. Reconstitution of nude mice with 10(7) syngeneic splenocytes 24 h before intracerebral inoculation with tsG31 KS5 VSV, however, protected 92% of the animals from death. When these reconstituted animals were injected intracerebroventricularly with 14 pmol of beta-endorphin 24 h after reconstitution with splenocytes and 24 h before inoculation with tsG31 KS5 VSV, only 72% of the animals survived. Furthermore, whereas 40% of the afflicted reconstituted nude mice given intracerebroventricular injections of sterile water were able to recover from the symptoms of disease, those surviving animals which received beta-endorphin were unable to do so. A single intravenous injection of 14 pmol beta-endorphin, or repeated postinfection administration of 28 pmol of beta-endorphin intravenously into nude mice reconstituted with syngeneic splenocytes, which were pretreated with beta-endorphin, did not alter the course of CNS disease induced by tsG31 KS5 VSV. The effect induced by intracerebroventricular injection of beta-endorphin was antagonized by naloxone, but not by the neuropeptide fragment beta-endorphin-(1-27). A simultaneous intracerebroventricular injection of reconstituted nude mice with 1220 pmol of naloxone and 14 pmol of beta-endorphin resulted in a 89% survival rate, and 33% of the afflicted animals were able to overcome the symptoms of the disease induced by tsG31 KS5 VSV. Intracerebroventricular injection of reconstituted nude mice with 330 pmol of beta-endorphin-(1-27) and 14 pmol of beta-endorphin resulted in a 72% survival rate and the surviving animals were unable to improve appreciably the clinical status of their disease. Injection of reconstituted nude mice with either 1220 pmol of naloxone or 330 pmol of beta-endorphin-(1-27) alone did not alter the course of the CNS disease in any way. A single intracerebroventricular injection of 29 pmol of another psychoactive peptide, [Des-Tyr]-endorphin, 24 h after reconstitution of nude mice with splenocytes and 24 h prior to infection with virus, resulted in 74% survival; and 39% of the afflicted animals were able to recover from the clinical symptoms.
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PMID:Beta-endorphin alters the course of central nervous system disease induced by a temperature-sensitive vesicular stomatitis virus in reconstituted nude mice. 216 Apr 76

The penetration of vesicular stomatitis virus (VSV) into the target cells is known to depend on the acid triggered receptor-mediated endocytosis pathway (RME). However, the possible contribution of phagocytosis and macropinocytosis both at early and late stages of infection and of plaque-forming process is unknown. Electron microscopic images of fibroblasts obtained one hour after VSV adsorption at 37 degrees C showed RME vesicles as well as clusters of particles in cytoplasmic inlets and phagocytic vacuoles which are morphologically similar with macropinosomes. Therefore, the possibility that VSV can use, in addition to RME, phagocytosis and macropinocytosis is discussed with respect to the wide range of host cell VSV infectivity and binding as well as to pseudotype formation.
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PMID:Electron microscopic observations of vesicular stomatitis virus particles penetration in human fibroblasts. 217 36

By tradition oral candidosis has been classified into acute pseudomembranous (thrush), acute atrophic, chronic atrophic, and chronic hyperplastic types. However, pseudomembranous candidosis is not always acute but may last for many months. Furthermore, the value of using the term atrophic to describe an erythematous area is limited. Moreover, some of the various types have been associated with other clinical entities, which appear to have a combined bacterial/mycologic etiology. A revision of the classification should be based on the use of clinical terms, and in a previous study of multifocal oral candidosis, erythematous, plaque-like, and nodular forms were identified. A revised classification of oral candidosis which considers these aspects could be as follows: acute types: pseudomembranous and erythematous; chronic types: pseudomembranous, erythematous, plaque-like, and nodular; and Candida-associated lesions: denture stomatitis, angular cheilitis, and median rhomboid glossitis.
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PMID:Classification and clinical manifestations of oral yeast infections. 218 11


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