Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038358 (
gastric ulcer
)
5,179
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Investigations were made of 2-(nicotinoylaminoethanesulfonylamino)pyridine (
NTP
), a new compound with anti-ulcer effects, to clarify the relationship between its biotransformation and pharmacological effects. The effect of
NTP
was investigated by using two types of experimental
gastric ulcer
models in rats. The anti-ulcer effect was revealed to be an action of
NTP
itself. In order to study the biotransformation of
NTP
, a quantitative analysis method by HPLC was established. When
NTP
was orally administered to rabbits, 2-(aminoethanesulfonylamino)pyridine (TP), which is a metabolite of
NTP
, appeared in plasma and lymph. When
NTP
was orally administered to rabbits to investigate its distribution in organs, a massive amount of
NTP
and TP appeared in various organs within 7 hr after administration. We conclude that the pharmacological effect of
NTP
appears to be associated mainly with the unchanged substance.
...
PMID:[Studies on the biotransformation and anti-ulcer effects of 2-(nicotinoylaminoethanesulfonylamino)pyridine]. 316 11
