Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To elucidate the mechanisms of desmoplasia of gastric cancer tissues, distribution of fibronectin (FN), fibrinogen (Fbg), alpha 2-plasmin inhibitor (alpha 2PI) and factor XIII (XIIIA) in fresh 49 gastric cancer tissues and 5 gastric ulcer tissues was studied by indirect immunofluorescent technique. FN existed scarcely in the basement membrane area of gastric cancer tubuli. FN and Fbg were distributed in same patterns abundantly in the stroma of all gastric cancer tissues regardless of their histological types. Neither alpha 2PI nor XIIIA was demonstrated in gastric cancer tissues. Autofluorescence of the cross-linked collagen fibers, which were seen in many gastric cancer cases, were surrounded with FN and Fbg. These results were well identical with those obtained from gastric ulcer tissues. These facts indicate that such a mechanism as non-specific wound healing process participates in desmoplasia of gastric cancer stroma as well as in fibrosis of gastric ulcer.
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PMID:[Distribution of fibronectin and other plasma proteins in gastric cancer tissues: investigation of mechanisms of desmoplasia of the stroma]. 639 98

The fibrillar collagens, types I and III, have been demonstrated in healthy human gastric mucosa as well as in the submucosa of gastric ulcer edges, where they were found to be remarkably increased. In order to verify the occurrence and activity of de novo collagen synthesis, we examined gastric biopsy specimens from six patients with antral ulcers and six normal controls. By means of in situ hybridization, using a 35-S-labelled RNA probe, we could identify the specific procollagen mRNA for type I collagen. Fibronectin was stained immunohistochemically employing specific polyclonal antibodies. In normal gastric mucosa, procollagen type I mRNA was expressed by only a very limited number of cells while at the ulcer edges the specific signal could be demonstrated in a large number of submucosal cells. Fibronectin as marker of newly built connective tissue was found to be markedly increased in the submucosa of healing gastric ulcers as compared to normal controls. These results suggest a substantial role of fibroneogenesis in the process of gastric ulcer healing.
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PMID:Collagen mRNA and fibronectin are increased in healing gastric ulcers in man. 759 38

Fibronectin (FN) is important for wound healing via cell proliferation, adhesion, differentiation, and matrix formation. Fetal types of FN mRNA, which include the region of EIIIA or EIIIB, are well expressed during embryonic development and wound healing. This study was done to investigate the mRNA expression of full-length FN, EIIIA- and EIIIB-FN, and the localization of FN in the gastric tissues during ulcer healing with northern blot analysis and immunohistochemical technique. Gastric ulcers in rats were produced by acetic acid. EIIIA- and EIIIB-FN mRNA were not detected in normal gastric tissues, but were expressed in the ulcerated tissues throughout the healing phase. However, on day 60 (in the scarred phase), the EIIIA- and EIIIB-FN mRNA had disappeared. The levels of full-length FN mRNA were increased from day 3 to 32 compared with the control levels, and decreased to the control levels on day 60. Full-length FN was predominantly localized at the mesenchyme around the infiltrating inflammatory cells in the granulation tissues and the basement membranes of the nonproliferating epithelial cells, which were regenerated at the ulcer margin. Thus, fetal gene transcripts of FN suggest the important role of fetal FN in gastric ulcer healing, mainly via the migration of mesenchymal and epithelial cells.
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PMID:Expression of gene for EIIIA- and EIIIB- fibronectin, fetal types of fibronectin, during gastric ulcer healing in rats. 1128 Nov 80