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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pharmacokinetics of orally applied single dose of paracetamol was studied in patients with gastric ulcer and duodenal ulcer. The course of changes in paracetamol concentration was described using a two-compartment open model for extravascular administration; the calculations were carried out using an Odra 1300 computer. The changes in pharmacokinetics of paracetamol in the patients with gastric and duodenal ulcer was altered: the absorption was increased particularly in patients with duodenal ulcerosis and delayed in patients with both gastric and duodenal ulcers.
Pol J Pharmacol Pharm
PMID:Pharmacokinetics of paracetamol in patients with gastric and duodenal ulcers. 646 61

The role of mucosal mast cells (MMC) in chronic non-allergic reactions of the gastric mucosa is unknown. The present study aimed to investigate the reaction of gastric MMC during healing of the acetic acid-induced gastric ulcer in the rat. Mast cells were stained with toluidine blue and alcian blue+safranin and their density and distribution were assessed. Morphometry of MMC and documentation of their contact with eosinophils were based on electron microscopy. In the normal non-injured rat oxyntic mucosa MMC are grouped in two populations: MMC1 concentrated near the glandular necks, and MMC2 in the basal lamina propria. There was a significant decrease in the number of MMC2 near the ulcer, whereas MMC1 lost their concentration in the neck zone. Also the MMC/connective tissue mast cells ratio was increased in the gastric wall adjacent to the ulcer. Eosinophils were commonly in close contact with MMC. Eosinophil cytoplasm adjacent to MMC was devoid of organelles, which were accumulated in the central cytoplasm. The significant redistribution of mast cell population as well as numerous close contacts between mucosal mast cells and eosinophils, taking place in the neighborhood of the chronic gastric ulcer, seem to be not only of morphological but also of functional significance.
Pol J Pathol 1995
PMID:The mast cells and an experimental gastric ulcer. Histochemical, ultrastructural and quantitative study in the rat. 871 89

The authors describe the case of six patients who after having undergone laryngectomy suffered from complications affecting digestive tract. One of the patients contracted aerophagy and in the case of five other patients occurred bleeding from the upper digestive tract. Four of the letter five patients had perforation of the gastric ulcer; three of them were treated surgically (in two cases by partial resection of the stomach, in one by ligation of the vessels in ulceration area) and in one case the conservative treatment was applied. All four above patients were completely cured of neoplasmatic illness such and the complications. In the fifth case developed a multiple ulceration of the esophageal wall and its perforation. The patient died as a result of massive and repeated bleeding, despite application of thoracosurgical treatment. In the sixth case, of the patient with aerophagy, the applied treatment was conservative.
Otolaryngol Pol 1996
PMID:[Complications of the digestive tract in patients after laryngectomy]. 905 67

The present study was carried out to value the histological method of detection of Helicobacter pylori in gastric mucosa and to analyse the pathological changes of the Helicobacter pylori-positive patients with duodenal and gastric ulcer and with chronic gastritis. The studies population consisted of 150 patients, 76 F and 74 M. The samples were taken during gastroscopy from the prepyloric region and gastric body. After routine histological procedure they were stained HE and by Giemsa method for detection of H.pylori. The latter was identified in 56.6% of of the patients with duodenal ulcer, in 54.8% of those with gastric ulcer, in 17.6% of the patients after partial gastrectomy and in 46.9% of patients suffering from chronic gastritis. The increased density of H.pylori (third grade) was detected in the cases with clinical diagnosis of duodenal and gastric ulcer and erythematous endoscopic gastritis and was correlated with the histological picture of chronic active gastritis, which was characterized by diffuse mixed cellular exudation, lesion of the superficial epithelial, mucosal erosions and by foveolar hyperplasia. We suggest that this morphological picture corresponded to the active phase of Helicobacter infection. We conclude, that the histological method by Giemsas staining is effective especially in the acute phase of H.pylori infection and represents high diagnostic value and may be used in monitoring during the antibacterial (anti H.pylori) treatment. There is the correlation between massive density of H.pylori observed in gastric mucosa and chronic active gastritis.
Pol Merkur Lekarski 1996 Sep
PMID:[Morphologic changes of gastric mucosa in Helicobacter pylori infection in patients with peptic ulcer disease and chronic gastritis]. 913 79

Haematologic disturbances in 13 cases of gastric cancer are described. All the patients had anemia of different origin. Increased leukocytosis was observed in half of the cases, leukemic reaction in one third. Hemolysis was present in 50% of cases. Thrombocytopenia coexisted most frequently with disseminated intravascular coagulation in 4 patients. Bone metastases were visualised as osteolytic foci with radiological methods or increased capture of isotopic marker in the bones under scintigraphic examination. Under the microscope neoplastic metastases were found in bone marrow smears of 5 patients. All patients displayed symptoms of gastric ulcer disease acute or chronic phase. In some cases only repeated gastroscopic examination and mucosa biopsy was the only way to confirm cancer. In other cases the diagnosis was made after the histopathologic examination of the resected stomach, in still others by a section.
Pol Merkur Lekarski 1997 May
PMID:[Hematologic changes in stomach cancer]. 937 91

Lansoprazole is the new proton pump inhibitor, decreasing the volume of gastric acid secretions and inhibiting secretion of gastric acid and pepsin. Lansoprazole appears to be more effective in therapy of gastric ulcer and duodenal ulcer in comparison with H2-receptor antagonists and omeprasole. Reflux oesophagitis and Zollinger-Ellison syndrome are also healed by Lansoprazole. The best results in the treatment of patients with peptic ulcer, reflux oesophagitis and Zollinger-Ellison syndrome were occurred after a daily 30 mg dose of Lansoprazole. Treatment of patients with duodenal ulcer should be continued for 2 to 4 week and the case of gastric ulcer a well as reflux oesophagitis should be prolonged till 4 to 8 week. Lansoprazole is well tolerated, reported adverse effects are similar to the incidence observed in patients treated with other proton pump inhibitors.
Pol Merkur Lekarski 1998 Jun
PMID:[Lansoprazol ++ : a new proton pump inhibitor]. 977 Oct 21

In 66 patients with peptic ulcer (11 with gastric ulcer, 55 with duodenal ulcer, 19 women, 47 men) the serum concentrations of prolactin, dehydrocholic acid and gastrin were determined. The studies were repeated after treatment with ranitidine: in 50 patients after three weeks and in 40 patients after another 30 days. During the first period ranitidine 2 x 150 mg was administered, while during the second period the dose was 1 x 150 mg. The results were compared with those obtained from 120 healthy subjects. Before starting the treatment prolactin levels were significantly higher than those in the control group. During the treatment a significant decrease of the levels was observed. Similar changes of prolactin concentrations were found in the group of 39 men with duodenal ulcer isolated from the studied patients, who were compared with a group of 50 healthy men. It was not found that the development of peptic ulcer and the treatment with ranitidine exerted and effect on the changes of gastrin and dehydrocholic acid concentrations.
Pol Tyg Lek 1995
PMID:[Serum concentration of prolactin, gastrin and glycocholic acid in patient with peptic ulcer treated with ranitidine]. 1178 98

Haematologic disturbances in 13 cases of gastric cancer are described. All the patients had anemia of different origin. Increased leukocytosis was observed in half of the cases, leukaemia reaction in one third. Haemolysis was present in 50% of cases. Thrombocytopenia coexisted most frequently with disseminated intravascular coagulation in 4 patients. Bone metastases were visualised as osteolytic foci with radiological methods or increased capture of isotopic marker in the bones under scintigraphic examination. Under the microscope neoplastic metastases were found in bone marrow smears of 5 patients. All patients displayed symptoms of gastric ulcer disease acute or chronic phase. In some cases only repeated gastroscopic examination and mucosa biopsy was the only way to confirm cancer. In other cases the diagnosis was made after the histopathologic examination of the resected stomach, in still others by a section.
Pol Tyg Lek 1995
PMID:[Haematologic changes in gastritic cancer]. 1178 3

Helicobacter pylori is a human pathogen that can be found all over the world. It is responsible for the following diseases of gastrointestinal tube: gastritis, gastric ulcer, duodenal ulcer, gastric cancer, gastric lymphomas, Menetier disease. Some research has been done recently trying to identify the connection between H. pylori infection and idiopathic Parkinson's Disease morbidity. Some of them show that people with this neurological disease are more likely to have ulcers and also seropositivity in the direction of H. pylori. The direct influence of H. pylori infection on Parkinson Disease is not known but the following relations are suggested: H. pylori may produce toxins that damage substantia nigra in brain; possible cross reaction of h. pylori antibodies with dopaminergic neurons; indirect influence of antacids containing aluminium used to alleviate the symptoms of ulcers. Investigations of the reasons for idiopathic parkinson disease draw attention to the influence of food factors. Some researches show that there is a relation between the frequency of eating certain foods and the parkinson disease morbidity. We have numerous techniques that allow us to diagnose h. pylori infection. Those techniques have different sensitivity, accuracy, invasiveness and costs, which determines their usefulness in clinical diagnostics. Approach to eradication of bacteria is still discussed because H. pylori infection doesn't always lead to health problems. Polish Working Group on Helicobacter pylori, called by the National Consultant's Team on Gastroenterology explained clearly when eradication is advisable and when it can be waived.
Pol Merkur Lekarski 2001 Nov
PMID:[Helicobacter pylori--does it only cause gastroduodenal disease?]. 1185 23

The objective of the present study was to investigate and compare the antiulcer effect of potassium channel openers, nicorandil and levcromakalim in the models of ulcer induced by pylorus ligation, aspirin and water immersion plus restraint stress in albino rats. Levcromakalim (250 microg/kg) and nicorandil (10 mg/kg) were administered intraduodenally immediately after pylorus ligation. Ulcer index was determined and gastric juice was subjected to analysis of total acid output (TAO) and pH. In aspirin-induced gastric ulcer model, the drugs were administered orally 30 min prior to noxious challenge, and in water immersion restraint stress model, the drugs were administered orally and ulcer index was determined. A significant reduction in ulcer index was observed after treatment with both potassium channel openers in all the gastric ulcer models. In pylorus-ligated rats, a significant decrease in TAO was noted. The conclusion is that potassium channel openers possess antiulcer activity. Antiulcer activity of levcromakalim is better than nicorandil but comparable to that of cimetidine. The antiulcer action of potassium channel openers is mediated partially by a decrease in gastric acid secretion, increase in gastric mucosal resistance and improvement in gastric mucosal blood flow.
Pol J Pharmacol
PMID:Antiulcer activity of levcromakalim and nicorandil in albino rats: a comparative study. 1285 31


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