Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diagnosis and successful eradication of Helicobacter pylori infection has been shown to be significantly related to symptom improvement in patients affected by chronic gastritis, duodenal and gastric ulcer. There is, therefore, an increasing need for the development of new, easy to use, reliable and non-invasive techniques to detect this organism. One such test is Flex-Sure (SmithKline Diagnostics Inc., United States), a new, rapid immunochromatographic test which requires a drop of the patient's serum to be placed on the absorbent pad of a strip. If specific antibodies to H. pylori are present a red colour line appears. The present study compared Flex-Sure with a homologous quantitative immunoenzymatic test (HM-CAP, EPI, US) using the same antigen (high molecular weight protein), the second generation GAP test (Bio-Rad, USA), a rapid urease test, culture and histology in a cohort of dyspeptic patients. We produced a semiquantitative visual scale with which to perform this comparison. Our results show that Flex-Sure possesses a sensitivity of 96.1%, a specificity of 73.9%, an overall accuracy of 78.8%, a positive predictive value of 72% and a negative predictive value of 91.6%. It showed a highly significant correlation with histological and cultural results (P < 0.001), and with the other serological tests (P < 0.0001). Based on our data we conclude that Flex-Sure may yield quick (within 4 min), simply readable, qualitative, and according to our colourimetric scale, even semiquantitative results. Furthermore, it does not require any sample dilution, any particular equipment, or any specialized training for the operator.
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PMID:Serodiagnosis of Helicobacter pylori: evaluation of a rapid, miniaturized immunochromatographic test. 785 77

To make clinical assessment regarding the role of Helicobacter pylori (H. pylori) in the occurrence of gastric cancer, we examined serological and microbiological positive rate of H. pylori and histological and endoscopic findings of atrophic gastritis of background mucosa in 149 gastric cancer patients, 136 gastric ulcer patients, 82 chronic gastritis cases and 46 normal control. Serological H. pylori positive rate examined using GAP-IgG in 43 gastric cancer patients was 95%, which was significantly higher than normal control (4%) but the same level as in chronic gastritis cases (87%) and gastric ulcer patients (93%). While, Microbiological H. pylori positive rate by culture was 62% in 149 gastric cancer, 7% in normal control, 74% in chronic gastritis and 80% in gastric ulcer. H. pylori infection and the degree of lymphocyte infiltration were significantly correlated and H. pylori was frequently detected in the cases with mild and moderate atrophic gastritis in all groups. No difference was observed in H. pylori positive rate between the well and poorly differentiated cancer cases; 96% and 94% by GAP-IgG, 57% and 66% by culture, respectively. As a conclusion, it was suspected that the relation between H. pylori infection and gastric cancer was indirect and associated with atrophic process of background mucosa.
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PMID:[Helicobacter pylori and gastric cancer in view of relation to atrophy of background gastric mucosa]. 828 41