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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the effect of restraint stress upon the degree of lipidic peroxidation in the fronto-temporal cerebral cortex, diencephalon, thymus and gastric mucosa. We determined the malon-dialdehyde (MDA) by spectrocolorimetry, the percentage of animals with stress gastric ulcer and the surface of gastric ulcerations. The results demonstrated an important increase of the MDA correlated with frequency and intensity of the gastric ulcer. In the second stage of the experiment, we studied the influence of the ubiquinone and melatonin on the same parameters studied in the first part. In every structures these two substances had antioxidative effect. For ubiquinone, results showed significant variations in the thymus and gastric mucosa, while at the cerebral level the results were doubtful. As antioxidant and antiulcerogenic factor, melatonin was more effective than ubiquinone, because determined significant decrease, or even disappearance of the peroxidative process in the cerebral cortex and the thymus and significantly diminished both peroxidation and ulcerogenesis in the gastric mucosa.
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PMID:[Melatonin and ubiquinone as endogenous antioxidant factors]. 1075 34

Highly reactive oxygen-free radicals are implicated in the pathogenic process of various diseases. Using an animal model of diabetes (alloxan-induced hyperglycaemia in mice), a model of gastric ulcer (indomethacin-induced gastric lesion in rats), and a model of bronchial asthma (ovalbumin-induced allergic bronchospasm in guinea pigs), a potential therapeutic effect was tested in known antioxidant drugs (alpha-tocopherol, ubiquinone), the thio-compound mesna, and drugs with a possible antioxidant effect (substances derived from the ergoline structure: 6-hydroxynicotinic acid and 4-hydroxypyridine). The pre-treatment with ubiquinone and 6-hydroxynicotinic acid almost completely prevented alloxan-induced hyperglycaemia (94 and 93% inhibition of hyperglycaemia, respectively). A weaker effect was shown by alpha-tocopherol and 4-hydroxypyridine (31 and 27% inhibition of hyperglycaemia, respectively). Mesna negligibly increased hyperglycaemia. 32% and 21% inhibitions of the number of gastric lesions were shown after administration of 6-hydroxynicotinic acid and alpha-tocopherol, respectively. Other drugs, most markedly mesna, aggravated gastric lesions. The most marked protective effect on ovalbumin-induced bronchospasm was exerted by 6-hydroxynicotinic acid (the pulmonary ventilation was increased by 84% in comparison with control group), while mesna and (alpha-tocopherol had a weaker effect (amelioration by 50 and 51 %, respectively). Ubiquinone and 4-hydroxypyridine aggravated pulmonary ventilation. The most marked protective effect in the animal models used was shown by 6-hydroxynicotinic acid.
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PMID:Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). 1108 99