Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038358 (
gastric ulcer
)
5,179
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Selenium-binding protein 1
(
SBP1
) has been shown to be greatly reduced in various human cancers. The purpose of this study was to evaluate the expression of
SBP1
in precursor lesions and gastric carcinoma (GC) and to discuss the specific role of
SBP1
in gastric carcinogenesis. Using tissue microarray (TMA) technology and immunohistochemical (IHC) survey,
SBP1
expressions were evaluated based on a semi-quantitative scoring system developed for this study in 25 paired of GC and corresponding nonneoplastic epithelia tissues, 21
gastric ulcer
, 13 gastric polyp, 19 chronic atrophic gastritis, 20 intestinal metaplasia, and 16 dysplasia tissues. We found abundant expression of
SBP1
in most precursor lesions in addition to the nonneoplastic epithelia tissues. However, the expression of
SBP1
was severely suppressed in most of the GC tissues (P=0.000). Although no statistical differences were found between the expressions of
SBP1
in gastric tissues with different levels of intestinal metaplasia or dysplasia (P>0.05), the reduction in
SBP1
seems to be correlated with clinical stage of GC (P=0.044). Thus,
SBP1
can be supposed as a diagnosis marker of GC. The suppression of
SBP1
may be a late event in gastric carcinogenesis.
...
PMID:Altered expression of selenium-binding protein 1 in gastric carcinoma and precursor lesions. 2048 Feb 65
