Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

IgA, IgM and IgC content in blood serum and gastric juice were determined in 89 patients with different gastric and duodenal diseases (57 with duodenal ulcers, 13 with gastric ulcers 8 with chronic atrophic gastritis, 9 with superficial chronic gastritis and gastroduodenitis and two with gastric cancer). Immunoglobulin was established in gastric juice (over 0,3 mg/100 ml) in 49 per cent of all the patients examined with gastric and duodenal diseases. No correlation was found between serum immunoglobulin level and their presence in the gastric juice. No correlation exists between the volume of the basal secretion and the presence or absence of immunoglobulins in the gastric juice. Immunoglobulins were established more often in the gastric juice with lower secretion of hydrochloric acid (in chronic atrophic gastritis and gastric ulcer), while in cases of higher secretion they are more frequently absent. A certain parallelism was established between the changes of hydrochloric acid output and JgA secretion in the gastric juice after stimulation of gastric secretion by Pentagastrin or histamine.
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PMID:[Immunoglobulins in the gastric juice in some stomach and duodenal diseases]. 122 82

During gastroduodenoscopic examination of 225 patients, bioptic mucosal specimens were taken for bacteriological and histological examination (Table 1). Campylobacter (C.) pylori was isolated from 7 out of 9 patients (78%) with gastric ulcer, from 59 out of 60 (98%) with duodenal ulcer, from 24 out of 31 (77%) with gastric erosions, from 10 out of 10 (100%) with duodenitis, from 14 out of 16 (88%) with chronic active gastritis, from 40 out of 73 (55%) with chronic inactive gastritis and from none out of 26 patients (0%) with normal mucosa (Table 2). To study the immune response an ELISA was developed which proved to give well reproducible and specific test results (Fig. 1). IgA- and IgG-titres were strongly reduced after absorption with C. pylori, but not with other antigens (including C. jejuni and C. coli, Table 3). Some sera gave reactions at higher titres when tested with the patient's own strain than with the standard antigen which is a mixture of 4 strains (Table 4). This indicates differences of the antigen composition within the species C. pylori. Sera from patients with positive culture showed higher IgG- and IgA-titres than sera from patients without isolation of C. pylori. The IgM-titres, however, were comparable in both groups (Fig. 3). Partially, sera from patients without C. pylori also showed high IgG-titres which were positively correlated with the patient's age. About 60% of culturally positive patients had specific IgA in their gastric juice, whereas this was not so with patients without isolation of C. pylori (Fig. 6). Examination of sera from healthy children and blood donors revealed that IgG but not IgA or IgM rose significantly with increasing age (Figs. 7-9). As can be concluded from the results of cultural and serological tests, C. pylori seems to be responsible at least for a part of cases of gastritis and peptic ulcer.
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PMID:Frequency of occurrence of Campylobacter pylori and analysis of the systemic and local immune response. 343 87

A study of the IgA levels in 43 duodenal ulcer (DU) patients and 8 gastric ulcer (GU) patients and their comparison with healthy controls reveals significantly elevated levels of IgA in DU and somewhat lower levels in GU. The levels were also associated with the genotypes of the patients for genetic markers such as ABO blood group, ABH sectetor status, haptoglobin, and alkaline phosphatase enzyme. Nutritional factors, such as vegetarianism, chili consumption, and habits such as smoking and alcoholism also showed variation in the IgA levels. These results indicate the response and role of IgA in the immunological mechanisms involving mucosal protection and autoimmunity in ulceration processes in the stomach.
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PMID:Serum levels of IgA in peptic ulcers. 360 96

Campylobacter pyloridis was isolated from 77% of 220 (35%) unselected adults undergoing gastroscopy. Isolation was significantly associated with histological gastritis (p less than 0.0001), duodenal ulcer (p less than 0.0001), and to a much lesser extent, with gastric ulcer (p less than 0.05). The relation between the isolation of C pyloridis and peptic ulcer seemed to be independent of coexisting gastritis. In those with no endoscopic or histological evidence of disease there was no relation between isolation and increasing age. Antibody responses to a whole cell sonicate of a strain of C pyloridis were measured by means of an enzyme linked immunosorbent assay (ELISA). Increased IgA (p less than 0.0001) and IgG (p less than 0.0001) antibody titres were found in patients with C pyloridis. Peptic ulceration or gastritis were present in 78% and 100% of patients with a high concentration of IgG and IgA, respectively, but in only 9% and 18% of those with low titres. These results provide further evidence for a possible pathogenic role of these organisms in gastric disease and suggest that immunological markers of their presence might be useful non-invasive indicators of disease.
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PMID:Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy. 395 46

Sera, duodenal liquid and biopsy materials of small intestine and of mesenteric lymph nodes were collected from 22 patients with colorectal cancer (intestinal lymphoma and adenocarcinoma) and 10 control patients with gastric ulcer were found in all of patients with cancer. The increasing of B type lymphocytes and decreasing of T cells were detected in biopsy materials and high level IgA was found in the sera and duodenal liquid of these patients. The immunological alterations were not seen in control patients with gastric ulcer. These findings suggest that there is a role of cellular and humoral immunological alterations in the development of colorectal cancer.
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PMID:[Immunological changes in patients with colorectal cancer]. 661 76

The IgG-, IgM- and IgA- anti-pneumococcal antibody response to pneumococcal vaccination in 29 splenectomized adults and adolescents with hereditary spherocytosis or previous traumatic splenic rupture was determined by an enzyme-linked immunosorbent assay. It was not significantly different from that of 12 healthy controls except for a lower IgM class antibody increase in the splenectomized against one of four antigens studied. The antibody response was predominantly of IgG class, but significant increases in IgM and IgA class antibodies against all four antigens (polysaccharide types 2, 6A, 12F and 14) studied were observed. In 1/29 splenectomized and 2/12 healthy individuals (7%) the IgG antibody class did not predominate. In 36 adults and adolescents splenectomized due to traumatic rupture or during surgery for gastric ulcer, 77% of the peak geometric mean total antibody concentration four weeks after vaccination was still present after 21 months (16-26 months).
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PMID:Immunoglobulin classes and persistence of anti-pneumococcal antibodies in splenectomized adults and adolescents after pneumococcal vaccination. 663 80

The distribution and localization of Helicobacter pylori (HP) and mononuclear cells (MNC) in the gastric mucosa were investigated immunohistochemically in 120 patients with gastritis or peptic ulcer. HP was detected in the gastric mucosa of 58% of 40 gastritis patients, 82% of 56 gastric ulcer (GU) patients, and 88% of 24 duodenal ulcer (DU) patients. In the HP-positive mucosa, cells positive for IgG or IgA were increased significantly when compared to the HP-negative mucosa. Neutrophils and eosinophils were also increased under the HP-infected surface and therefore these cells were likely involved in the mucosal damage. Enhancement of the expression of HLA-DR antigen was observed in the gastric epithelium with HP infection and it was associated with a significant increase of lymphoid follicles and B cells in the mucosa. In comparison with the HP-infected mucosa of gastritis patients, the number of MNC were increased significantly in the mucosa of both DU and GU patients. The number of HP in the gastric mucosa of DU patients was significantly higher than those of both gastritis and GU patients. In addition, the grade of the infiltration of MNC and IgA positive cells were always greater in DU than in gastritis, regardless of the number of HP. These findings suggested that activation of the local immunity in the gastric mucosa of gastritis and peptic ulcer patients by HP infection may participate in the pathogenesis of gastroduodenal mucosa damage.
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PMID:[Immunohistochemical study of Helicobacter pylori and mononuclear cells in the gastric mucosa of patients with gastritis or peptic ulcer]. 819 6

In 25 patients with duodenal ulcer, before treatment and after three weeks, and another 30 days of treatment with ranitidine, plasma concentrations were determined of IgA, IgG, IgM immunoglobulins, and of 10 other proteins. In comparison to the control group of 20 persons, a statistically significant decrease was found in the concentration of alpha 2-M, prealbumins, and IgG, as well as a significant increase of alpha 1-AT, C4 complement component, and a non-significant increase of coeruloplasmin, haptoglobin and IgM. During the treatment a tendency was observed for an increase of IgG and IgM level, as well as a statistically significant decrease of alpha 1-AT, C4, and coeruloplasmin concentration. The treatment exerted no effect on the decreased level of alpha 2-M. It was accepted that the tendency for an increase of IgG and IgM level was due, most probably, to the immunostimulating action of ranitidine, and the changes of concentrations of other parameters induced by the treatment were related to the presence and healing of the ulceration. The observed decrease of alpha 2-M level was probably due to binding of alpha 2-M to pepsinogen whose blood level was increased during gastric ulcer.
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PMID:[Changes of IgA, IgG and IgM immunoglobulins and of 10 other plasma proteins in patients with duodenal ulcer treated with ranitidine]. 824 88

Autoantibodies to serum IgA and IgG were detected in 206 peptic ulcer patients (196 duodenal ulcer and 10 gastric ulcer) and 52 healthy age and sex-matched controls by indirect haemagglutination test. A significantly increased mean titre of autoantibodies to serum IgA was observed in the peptic ulcer patients. Forty-eight (24.61%) duodenal ulcer cases had autoantibody titre values above mean +/- 2 SD of controls. Titres of autoantibodies to serum IgG were significantly increased only in the gastric ulcer cases. The results suggest an immunologic abnormality in a sizeable fraction of these cases.
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PMID:Detection of antibodies to serum IgA and IgG in peptic ulcer cases by indirect haemagglutination test. 827 46

The detection of Helicobacter pylori in gastric juice by the polymerase chain reaction (PCR) was undertaken in 124 patients with peptic ulcer or chronic gastritis. PCR products were evaluated by agarose gel electrophoresis and Southern hybridization of H. pylori-specific DNA sequences. Positive and negative results of the PCR analysis in 72 examinations were compared with those from bacterial culture, and with the detection of tissue IgA antibody against H. pylori by enzyme-linked immunosorbent assay ELISA; Serion, Wuerzburg, Germany, and detection of serum IgG antibody against H. pylori by ELISA; Radim Pomezia, Italy. Thirty-four PCR-positive samples evaluated by electrophoresis and hybridization coincided with positive samples in 56% of bacterial cultures, 59% of tissue IgA antibody identifications, and 94% of serum IgG antibody evaluations; 26 PCR-negative samples coincided with negative samples in 96% of bacterial cultures, 81% of tissue IgA antibody evaluations, and 38% of serum IgG assessments. We compared the detection achieved with the H. pylori PCR assay in gastric juice with that in biopsies taken from the antrum and upper corpus in 90 examinations, and found them to be both positive in 34 (38%) and 36 (40%) of specimens, both negative in 37 (41%) and 30 (33%) specimens, gastric juice-positive but biopsy-negative in 10 (11%) and 12 (13%) specimens, and vice versa in 9 (10%) and 12 (13%) specimens, when detected by electrophoresis and hybridization, respectively, showing equivalent detection rates. In relation to the type of disease, the positive PCR assay results with gastric juice, evaluated by electrophoresis and hybridization, respectively, were: gastric ulcer 34/53 (64%) and 39/53 (74%), duodenal ulcer 23/38 (61%) and 25/38 (66%), and chronic gastritis 20/33 (61%) and 23/33 (70%), showing no significant difference in positive rates between peptic ulcer and chronic gastritis. Of the samples of 16 patients with H. pylori-positive gastric juice by the PCR assay, 7 were negative by PCR assay analyzed by electrophoresis and hybridization after the completion of treatment H. pylori. However, after treatment, 3 were negative on electrophoresis but still had positive results with hybridization, indicating that a minimal number of bacilli may have still remained. Detection of H. pylori in gastric juice has potential advantages for examining H. pylori infection in the entire stomach and for follow up after treatment for the eradication of H. pylori.
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PMID:Detection of Helicobacter pylori DNA in gastric juice by the polymerase chain reaction: comparison with findings in bacterial culture and the detection of tissue IgA and serum IgG antibodies against Helicobacter pylori. 896 84


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