Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Most studies of gastric transmucosal potential difference concern acute damage. We studied this phenomenon in 168 patients with different pathologic processes: erosive gastritis, duodenal and prepyloric ulcer, atrophic gastritis, gastric ulcer and normal controls. Ag-AgCl electrodes and Agar-KCl bridges were used to record potential differences. Biopsies were taken from gastric antrum and body and potential differences were related to endoscopic and histologic findings. Maximal values of -29.2 + 2 and -22.2 + 1.6 for body and antrum, respectively, were found in normals. Lowest values (-19.4 + 1.4 and -14.3 + 1.5, respectively) were found in gastric ulcer, with intermediate values for the other conditions. Normal histologic findings were associated to potentials of -31 + 2 and -20 + 3.1 whereas lower values were recorded in patients with moderate or severe atrophic changes. Our findings suggest a relation between mucosal atrophy and lower transmucosal potential differences.
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PMID:[Potential difference of the gastric mucosa in gastroduodenal disease. Relation with endoscopical and histologic findings]. 251 90

The concentration of serum and intraperitoneal exudate after dripping intravenous administration of CTM were measured. Four male cases of the emergent laparotomy, a Cushing's ulcer, a hemorrhagic gastric ulcer, an adhesive ileus and acute terminal ileitis were investigated on this study. Two grams of CTM dissolving into 100 ml of physiological saline solution were prepared and administered in a period of 1 hour by intravenous drip (i.v.d.) for all cases after operation. The measurement of CTM-concentration in serum and intraperitoneal exudate were made at 30 minutes, 60 minutes following administration by serum and intraperitoneal exudate were made at 30 minutes, 60 minutes following administration by i.v.d. and at 30 minutes, hourly intervals over a 6-hour period after total administration. The intraperitoneal exudate for this study were collected through a drain which provided at the operation. These samples were measured by Agar-well method at Takeda Central Research Laboratory. Takeda Co., Ltd. The mean value of serum CTM at 30 minutes after the beginning of i.v.d. administration was 65.7 micrograms/ml and the maximum value, 79 micrograms/ml was obtained at 60 minutes. The following mean values at 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours and 6 hours after total administration were 39.1, 26.4, 14.6, 8.9, 4.7 and 0.6 microgram/ml. On the other hand, the mean values of CTM intraperitineal exudate at the same time intervals were 4.9, 20.7, 32.0, 34.3, 22.4, 13.9, 11.2, 8.7 and 3.3 micrograms/ml. These results showed that there were much transfer of CTM between serum and intraperitoneal exudate corresponding to the amount of administration.
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PMID:[Distribution of cefotiam dihydrochloride to the intraabdominal exudate (author's transl)]. 628 21