Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study investigated a stimulating effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacryl acid on proliferative processes in the connective tissue in development of experimental gastric ulcer. The drug was found to exhibit an ulcerostatic effect, to change the levels of collagen, noncollagen proteins, glycosaminoglycan fractions, DNA and RNA.
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PMID:[Ulcerostatic effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacryl acid and its possible mechanisms]. 128 Jan 72

It was demonstrated in experiments on rats with acetate gastric ulcer that ammonium salt tris-(2-hydroxyethyl) of iron-containing polyacrylic acid intensifies the development of granulation-fibrous tissue and promotes fuller restoration of connective-tissue polymers--collagen, noncollagenous proteins, and glycosaminoglycans in it. The biochemical results are confirmed by histological studies.
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PMID:[Analysis of the mechanism of the ulcerostatic effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacrylic acid]. 148 Apr 26

To clarify the mechanism of gastric ulcer recurrence, we studied acetic acid-induced gastric ulcers. The healing of these gastric ulcers was then studied for 4-21 weeks after the injection. Forty-eight ulcers were examined by macroscopic observation and scanning acoustic microscopy (SAM) and by histologic study of the ulcers. SAM has a higher radio frequency and provides more detailed information about the gastric wall than endoscopic ultrasonography (EUS). Thirteen healed and 35 non-healed gastric ulcers were observed by macroscopic observation over 4-21 weeks. SAM enabled us to observe the normal gastric wall of the rat in five different layers. The SAM echo patterns of the healed ulcers were all one pattern. On the other hand, we were able to classify the echo patterns of the non-healed ulcers into two different patterns; one pattern consisted of a high-echogenic region in the first and second layers with an underlying relatively high echogenic region in a horizontal pattern. The other pattern showed a poorly defined and spotted low-echogenic region in the first and second layers which fanned out toward the fifth layer. However, these two different ulcers could not be distinguished macroscopically. Histologic findings supported the results of the SAM study which showed one pattern in healed ulcers and two patterns in non-healed ulcers. In the non-healed ulcers the two different patterns may be ascribed to the proliferation of collagen fibers. SAM makes it possible to image the proliferation of collagen fibers and identify the two different types with an accuracy of 97%.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Evaluation of acetic acid-induced gastric ulcers in rats by scanning acoustic microscopy. 185 54

To elucidate the mechanisms of desmoplasia of gastric cancer tissues, distribution of fibronectin (FN), fibrinogen (Fbg), alpha 2-plasmin inhibitor (alpha 2PI) and factor XIII (XIIIA) in fresh 49 gastric cancer tissues and 5 gastric ulcer tissues was studied by indirect immunofluorescent technique. FN existed scarcely in the basement membrane area of gastric cancer tubuli. FN and Fbg were distributed in same patterns abundantly in the stroma of all gastric cancer tissues regardless of their histological types. Neither alpha 2PI nor XIIIA was demonstrated in gastric cancer tissues. Autofluorescence of the cross-linked collagen fibers, which were seen in many gastric cancer cases, were surrounded with FN and Fbg. These results were well identical with those obtained from gastric ulcer tissues. These facts indicate that such a mechanism as non-specific wound healing process participates in desmoplasia of gastric cancer stroma as well as in fibrosis of gastric ulcer.
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PMID:[Distribution of fibronectin and other plasma proteins in gastric cancer tissues: investigation of mechanisms of desmoplasia of the stroma]. 639 98

It is shown that the level of DNA, RNA, collagen, non-collagen proteins, hexoses and glycosaminoglycans is changed when making the experimental gastric ulcer in rats. Solcoseryl stabilises the level of DNA, RNA and collagen, stimulating the reparation processes in ulcer.
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PMID:[Solcoseryl: Ulcerostatic effect and possible mechanisms]. 751 1

The fibrillar collagens, types I and III, have been demonstrated in healthy human gastric mucosa as well as in the submucosa of gastric ulcer edges, where they were found to be remarkably increased. In order to verify the occurrence and activity of de novo collagen synthesis, we examined gastric biopsy specimens from six patients with antral ulcers and six normal controls. By means of in situ hybridization, using a 35-S-labelled RNA probe, we could identify the specific procollagen mRNA for type I collagen. Fibronectin was stained immunohistochemically employing specific polyclonal antibodies. In normal gastric mucosa, procollagen type I mRNA was expressed by only a very limited number of cells while at the ulcer edges the specific signal could be demonstrated in a large number of submucosal cells. Fibronectin as marker of newly built connective tissue was found to be markedly increased in the submucosa of healing gastric ulcers as compared to normal controls. These results suggest a substantial role of fibroneogenesis in the process of gastric ulcer healing.
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PMID:Collagen mRNA and fibronectin are increased in healing gastric ulcers in man. 759 38

The healing process of gastric ulcers is regulated by many factors. Cytokines play a central role in the different stages of healing. In the early stage of inflammation, TNF-alpha and interleukins regulate cell-migration and -proliferation. In the ulcer's base revascularisation is stimulated by b-FGF, collagen synthesis by TGF-beta. The reepithelialization is mediated by EGF, which accelerates ulcer healing in animal models, while TGF-alpha is involved in mucosal protection. The extracellular matrix (ECM) is important for the stability and quality of the ulcer scar, as known from dermatological experiments. An increase of collagen types I and III in healing gastric ulcers was demonstrated recently, which might illuminate the particular role of ECM proteins for the gastric ulcer healing process.
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PMID:[The significance of cytokines and extracellular matrix for stomach ulcer healing]. 787 61

The stimulatory action of Bacillus mucilaginosus exopolysaccharide on proliferative processes in experimental gastric ulcer healing. With the drug, the levels of collagen, noncollagen proteins, glycosaminoglycans, DNA, and RNA in the ulcer tissue.
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PMID:[The ulcerostatic effect of the exopolysaccharide from Bacillus mucilaginosus and its possible mechanisms]. 831 41

Oxygen free radicals have been implicated in the pathogenesis of gastrointestinal mucosal injury. However, their effect on the quality of experimental gastric ulcer healing has not been investigated previously. Gastric ulcers were produced on the anterior wall of the stomach of rats by submucosal injection of 20% acetic acid. To investigate the role of oxygen radicals, rats with gastric ulcers were treated with scavengers for 6 weeks. Rats received either a daily dose of 20,000 U/kg of recombinant human Cu,Zn-SOD, a 1% solution of DMSO administered orally ad libitum, or 50 mg/kg/day of allopurinol administered orally. The quality of ulcer healing was evaluated by histologic and biochemical parameters: ulcer area, lipid peroxide levels, abnormality of regenerated mucosa, angiogenesis, and fibrosis as assessed by Azan staining, mucin content as assessed by the PAS-positive area, and polymorphonuclear leukocyte (PMN) infiltration. The treatments with SOD, DMSO, or allopurinol did not affect the ulcer area or lipid peroxide levels in the gastric mucosa, and SOD did not affect the histologic abnormality score, PMN infiltration in regenerated mucosa, the collagen fiber proliferation index, or the PAS-positive mucous score. DMSO and allopurinol significantly increased the collagen fiber proliferation index and the PAS-positive mucous score compared with controls. These results indicate that scavenging hydroxyl radicals or inhibiting xanthine oxidase enhances the quality but not the speed of gastric ulcer healing.
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PMID:Effects of oxygen radical scavengers on the quality of gastric ulcer healing in rats. 877 96

The sensitivity and practicability of in situ hybridization methods utilizing isotopic or non-radioactive labeling were compared. The aim of this study was to determine whether digoxigenin-labeled riboprobes are as sensitive as 35S-labeled probes to detect changes in type I and IV procollagen expression in an animal model of rat gastric ulcer. Both labeling and detection methods yielded similar results, with a superimposable signal distribution in the specimens. High levels of procollagen type I and IV transcripts were observed in spindle-shaped cells, presumably fibroblasts or myofibroblasts, localized in the ulcer base and rim. The increased expression of these collagen types suggests a remarkable upregulation of collagen expression during the healing of gastric ulcers. Liver tissue adhering to perforated ulcers displayed signals related to non-parenchymal cells, with hepatocytes demonstrating no detectable transcripts of type I or IV collagen genes. Due to the identical pattern of signal distribution by both hybridization techniques it is concluded that non-radioactive in situ hybridization is of value in monitoring highly expressed genes and yields results similar to those achieved with radioactive probes. In these cases, non-radioactive techniques are preferable because they are performed more rapidly and do not require handling of isotopes.
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PMID:Expression of type I and IV collagen mRNAs in healing gastric ulcers--a comparative analysis using isotopic and non-radioactive in situ hybridization. 891 69


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