Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case is described where a 3-month-old boy who had osteogenesis imperfecta with multiple fractures presented with vomiting and bleeding. A gastric ulcer was diagnosed by endoscopy but could not be visualized by repeated radiography. In spite of adequate treatment with H2-antagonists and antacids the bleeding recurred three months later. Development of hypertrophic pyloric stenosis was diagnosed and pyloromyotomy was performed after which the patient recovered without further recurrences. This case suggests that multiple ulcerogenic factors should considered and treated in pediatric patients with recurrent secondary ulcers in spite of appropriate treatment.
Ugeskr Laeger 1989 Sep 25
PMID:[Recurrent secondary stomach ulcer in a boy 3 months of age with osteogenesis imperfecta]. 280 31

A fatal case of perforation of a gastric ulcer in a 4 1/2-year-old child is presented and discussed.
Ugeskr Laeger 1989 Sep 25
PMID:[Fatal acute stomach ulcer perforation in a 4-year-old child]. 280 32

N,N-Diethyl-2-[4-(phenylmethyl)-phenoxy]-ethanamine hydrochloride (DPPE) is a para-diphenylmethane derivative that binds selectively and with high affinity to the microsomal antiestrogen binding site (AEBS). Recent studies with DPPE indicate that AEBS is closely related to a lower affinity non-H1, non-H2 histamine site that may be associated with calcium channels; the DPPE-AEBS site is different from that which verapamil binds, however, DPPE, but not verapamil, demonstrates antiproliferative effects in vitro and is antiestrogenic in vivo. We now show that DPPE profoundly inhibits restraint and cold stress and ethanol-induced gastric ulcer formation, accelerates ulcer healing, attenuates the stress-induced rise in plasma corticosterone level, and significantly reduces basal and H2 agonist (dimaprit)-stimulated and, to a lesser extent, bethanechol-stimulated gastric acid output in conscious rats. A nonulcerogenic but prostaglandin-depleting dose of indomethacin completely blocks the inhibitory effects of DPPE on stress ulcer formation. Conversely, verapamil only slightly attenuates dimaprit-stimulated gastric acid secretion and exacerbates ethanol-induced gastric ulcers; its anti-stress ulcer effects are only partially attenuated by indomethacin. These findings support the likelihood that the site of action of DPPE is different from that of verapamil, and that an effect on prostaglandins may, at least in part, contribute to its antiulcer and apparent cytoprotective effects.
Can J Physiol Pharmacol 1988 Sep
PMID:Antiulcerogenic and antisecretory effects of a novel diphenylmethane derivative and antiestrogen binding site ligand. 290 33

Post-operative morbidity and mortality factors were investigated in a retrospective study of 34 patients aged over 70 operated upon for gastric ulcer. In two-thirds of the patients the operation was motivated by a complication of the ulcer. Two-thirds presented with an concurrent disease at the time of surgery. Fourteen patients died in hospital during the post-operative period, this mortality being related to the concurrent disease. Bleeding of the ulcer and emergency surgery were aggravating factors. The absence of post-operative abdominal complications had more influence on the prognosis than the type of operation performed.
Presse Med 1986 Sep 27
PMID:[Risk factors in gastric ulcer surgery after the age of 70 years. 34 cases]. 294 8

Fasting and postprandial intragastric bile acid concentrations were determined in healthy subjects and in patients with gastric and duodenal ulcer. The results showed great interindividual variation and wide overlapping between groups. Mean bile acid concentrations, fasting and postprandially, were significantly higher in patients with gastric ulcer than in healthy subjects. The differences between gastric and duodenal ulcer patients and between duodenal ulcer patients and healthy subjects were not significant. Fiber-enriched wheat bran reduced bile acid concentrations significantly in patients with gastric ulcer disease.
Scand J Gastroenterol 1985 Sep
PMID:Intragastric bile acid concentrations in healthy subjects and in patients with gastric and duodenal ulcer and the influence of fiber-enriched wheat bran in patients with gastric ulcer. 299 18

We have developed a new endoscopic system for measuring the three-dimensional structure of the gastric ulcer. The system consists of an argon ion laser generator, a side-viewing endoscope with diffraction grating made of glass fibers, and a graphic processing unit. Via a fiber grating fitted in the tip of the endoscope, about 1600 light spots produced by the diffracted laser beam were projected on to the gastric mucosa. By graphic processing involving the detection of the deviation of the laser spot array on the gastric lesion, the diameter, area, and height or depth of the lesion could be determined. To evaluate the accuracy of the system, the diameter and area of a rubber disc were determined in vitro and in the stomach. A cubic model 10 mm in height was used to evaluate the accuracy of the system in measuring height. Accuracy proved to be satisfactory for clinical use. The course of healing of 6 gastric ulcers treated by histamine receptor antagonist was followed with the system. A linear decrease in diameter and depth of the ulcer was observed.
Endoscopy 1988 Sep
PMID:Three-dimensional determination of gastric ulcer size with laser endoscopy. 316 40

A study was conducted in Sichuan, China to further determine if any correlation exists between vasectomy and the risk of heart disease. In a retrospective analysis of 4596 men who had received vasectomies and 4340 who had not been vasectomized, it was found that the cardiovascular status of men who had had a vasectomy was actually better that those who had not. The mean duration since the operation was 14.5 years with a range of 10-25 years. The results confirmed past conclusions that vasectomy is not linked with coronary disease. Testing for other endpoints and areas such as stomach ulcer and hypertension indicated that men who had received a vasectomy were in general in better health. Resting ECG changes and positive ECG changes following a stress test further confirmed the results. Mortality associated with vasectomy was also examined with no negative connection found. Vasectomy has been extensively studied and has been proven repeatedly to be a safe procedure that is not linked to adverse effects.
Int J Epidemiol 1988 Sep
PMID:Vasectomy and health: cardiovascular and other diseases following vasectomy in Sichuan province, People's Republic of China. 320 41

Gastric ulceration is frequently reported to occur in tumour-bearing animals and man, even when such tumours are not associated with organs of digestion. That central and peripheral dopamine (DA) containing neurones may be relevant to this phenomenon, is supported by the fact that the DA receptor antagonists domperidone (0.1 and 0.05 mg/kg) and pimozide (0.1 mg/kg) were observed to prevent gastric ulceration commonly reported in rats bearing the Walker 256 carcinosarcoma. Daily administration of these drugs prevented the formation of ulcers similar to those observed in vehicle-treated animals. These results demonstrate that DA neurone function is important in the formation of gastric ulcers in tumour-bearing animals and suggest that such compounds may be useful in cancer management.
Pharmacol Biochem Behav 1988 Sep
PMID:Observations on dopamine receptor antagonists and gastric ulceration associated with experimental anorexia cachexia. 325 63

Campylobacter pylori, a bacterium specifically adapted to the environment of gastric mucous is closely associated with peptic gastric diseases. It is detected within the mucus and in relationship to the intercellular spaces in cases of active chronic gastritis. Approximately 70% of patients with chronic type-B-gastritis are infected with C. pylori. In type A or reflux gastritis C. pylori is hardly seen. A causal relationship seems likely. More than 80% of patients with duodenal ulcer and round half of the cases with gastric ulcer show C. pylori in the gastric mucosa. The pathomechanism, how C. pylori facilitates the development of peptic ulcer is since hypothetical. It is discussed that the bacterium leads to a local breakdown of gastric mucosal defence.
Z Gastroenterol 1987 Sep
PMID:[Campylobacter pylori colonization of the antrum mucosa in patients with chronic gastritis and peptic ulcer]. 331 89

The records of all children with peptic ulcer disease at the Hospital for Sick Children were retrospectively evaluated, excluding neonates, throughout a 5-year period. Only cases with a definite ulcer crater identified either at endoscopy or at surgery were included. There were 36 patients, 20 boys and 16 girls. Duodenal ulcers were more common than gastric ulcers (2.8:1). Ages ranged from 3 months to 17 years, with a mean age of 10 years. Patients were reviewed with respect to etiology of peptic ulcer disease, age when first examined, initial symptoms, and clinical course. Patients were divided into two groups, those with primary (n = 19) and those with secondary (n = 17) peptic ulcer disease. All peptic ulcers in patients younger than 10 years of age were secondary in nature. Secondary ulcers occurred generally in association with a severe underlying illness (11/17), and many ulcers necessitated emergency surgery because of perforation and/or severe hemorrhage (8/17). None of these patients had chronic or recurrent symptoms. In contrast, in children with primary peptic ulcer disease, initial symptoms were more benign. Most patients had abdominal pain and only one required emergency surgery. Children with primary duodenal ulcer disease had a high incidence of recurrent symptoms (67%), however, with surgery for intractable disease necessitated in 40%. Single-contrast barium meals were found to be unreliable in establishing a diagnosis of peptic ulcer disease, particularly cases of gastric ulcer disease.
Pediatrics 1988 Sep
PMID:Peptic ulcer disease in children: etiology, clinical findings, and clinical course. 340 76


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