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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

21 patients with peptic ulcers were treated with 2X25 mg Pirenzepin daily. A decrease in basal and Pentagastrin-stimulated HCl-secretion was found. Patients with duodenal ulcers (n = 12) or gastric ulcers (n = 9) became painless within 6 to 11 days. 18 ulcers healed under treatment with Pirenzepin. Patients with duodenal ulcer showed recovery sooner than patients with gastric ulcer. One year later recurrent ulcers were observed in 4 cases. Side-effects of Pirenzepin did not occur.
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PMID:[Experiences with Pirenzepin in the therapy of peptic ulcers (author's transl)]. 52 96

Ulcer was induced in the anterior wall of the antrum by injection of acetic acid solution. Carbonized microspheres 15 +/- 5 mj in diameter and labelled with 85Sr and 141Ce were used to measure blood flow in different regions and layers of the stomach. The radioactivity of the blood and tissue samples was determined, and the blood flow was calculated for each tissue sample. Three groups of anaesthetized animals were used: 1) animals, with normal stomachs, 2) animals with normal stomachs given pentagastrin, 3)animals with a one-week ulcer given pentagastrin. In animals with normal stomachs given pentagastrin during 20 minutes, the mucosal blood flow increased in all areas of the stomach apart from the antrum. In animals with a gastric ulcer pentagastrin was not found to influence the mucosal blood flow significantly. Pentagastrin was not found to change the muscularis flow in animals with normal stomachs, or in animals with a gastric ulcer.
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PMID:Effect of pentagastrin on blood flow distribution in the stomach of cats with gastric ulcer. 83 72

The following observations have been made: 1. The viscosity of a substance as complex as mucus requires study at different rates of shear and shear stresses. 2. Visible gastric mucus behaves as a pseudoplastic substance. 3. Duodenal ulcer patients have a higher gastric mucus viscosity than controls. 4. Pentagastrin stimulation in duodenal ulcer patients leads to the secretion of gastric mucus of low viscosity. 5. This decrease in the viscosity of gastric mucus on pentagastrin stimulation does not occur in patients with gastric ulcer. 6. Truncal vagotomy leads to an increase in the viscosity of gastric mucus under basal and stimulted conditions.
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PMID:Gastric mucus viscosity and peptic ulcer. 93 Jul 22

IgA, IgM and IgC content in blood serum and gastric juice were determined in 89 patients with different gastric and duodenal diseases (57 with duodenal ulcers, 13 with gastric ulcers 8 with chronic atrophic gastritis, 9 with superficial chronic gastritis and gastroduodenitis and two with gastric cancer). Immunoglobulin was established in gastric juice (over 0,3 mg/100 ml) in 49 per cent of all the patients examined with gastric and duodenal diseases. No correlation was found between serum immunoglobulin level and their presence in the gastric juice. No correlation exists between the volume of the basal secretion and the presence or absence of immunoglobulins in the gastric juice. Immunoglobulins were established more often in the gastric juice with lower secretion of hydrochloric acid (in chronic atrophic gastritis and gastric ulcer), while in cases of higher secretion they are more frequently absent. A certain parallelism was established between the changes of hydrochloric acid output and JgA secretion in the gastric juice after stimulation of gastric secretion by Pentagastrin or histamine.
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PMID:[Immunoglobulins in the gastric juice in some stomach and duodenal diseases]. 122 82

The results of selective proximal vagotomy and pyloroplasty for duodenal and gastric ulcer in 464 patients over the last 5 years were evaluated in 438 cases. More than 75% of the patients were observed for 2 years after the operation. More than 25% were emergency cases, the incidence of intraoperative complications like splenic lesions or perforation of the esophagus was 3.2%. Postoperative complications like leakage of the pyloroplasty, peritonitis, hemorrhage from the pyloroplasty or disruption of the laparotomy closure occurred in 14,4%. The overall mortality was 4.6%, the elective mortality 1.6%. Recurrent ulcers were seen after 1/2-2 1/4 years with an overall rate of 3.2%. Over half of these cases required relaparotomy. In 5.3% relaparotomy had to be done for peritonitis, GI-bleeding, bleeding from the lesser curvature of the stomach, ileus or carcinoma. The Pentagastrin stimulated gastric secretion remained constantly reduced for more then 2 years in over 60%. Following the Visick-grading system the results were good in 61-65% of the patients and bad in 16-22% depending on the time of observation.
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PMID:[Clinical results by selective proximal vagotomy with pyloroplasty (author's transl)]. 125 50

Hydrogen clearance was used to assess blood flow in fundal and antral gastric mucosa as well as in the lobule of the auricle in 127 patients with ulcer (99 duodenal and 28 gastric ulcer cases), 34 patients with gastric, duodenal, pancreatic and biliary ++non-ulcer lesions against 20 healthy subjects. The findings underwent analysis in relation to the disease form and phase, baseline characteristics of the mucosa (morphological, functional and bacteriological) and changes in them in response to pentagastrin (6 micrograms/kg), alupent (0.0075 mg/kg), clofelin (0.0015 mg/kg) administration. For ulcer involving the body of the stomach and sutured perforated duodenal ulcer, fundal and antral mucosa blood flow showed a decrease by 1/3, the lowest values presenting in the active disease phase. Diminution in gastric mucosa blood flow correlated with gravity of its gastritic lesion and was not directly related to its Campylobacter contamination. Pentagastrin stimulated blood flow in fundic mucosa and led to its 30% increase whereas the flow intensity remained unaffected in the antral mucosa and skin (lobule of the auricle). Acid production in response to pentagastrin introduction rose 3.5-fold, pepsin 2.1-fold. Alupent and clofelin do not affect blood flow causing a 30-50% increase and decrease in acid and pepsin production, respectively. Separate neurohumoral regulation of gastric mucosa blood flow and secretory activity of the latter permits differential correction of each of the impaired functions.
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PMID:[Characteristics of blood flow in the gastric mucosa in relation to its structure and function in patients with peptic ulcer]. 194 70

The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 times/day). Animals received the diet regimen for 10 days from 1 day after induction of ulcer (day 0). Following the feeding regimens, serum gastrin levels, oxyntic gland mucosal DNA synthesis, and gastric secretory function were significantly lowered in the rats fed liquid diets. DNA synthesis in the duodenal mucosa was not different from the pre-ulcer levels. Pentagastrin significantly restored the DNA synthetic and gastric secretory activity of the liquid diet-fed rats toward the levels in the chow-fed group. In the latter group, a significant increase in DNA synthesis and levels of serum gastrin was found at day 6 (after 5 days feeding), which corresponded with a rapid, spontaneous healing of ulcers. Feeding rats liquid diet significantly delayed the healing of gastric, but not duodenal ulcers. Repeated administration of pentagastrin accelerated gastric ulcer healing in the liquid diet group toward the rate observed in the chow-fed group, but had no effect on the healing of duodenal ulcers. These results indicate that cell proliferation is an important factor in the healing of gastric ulcers.
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PMID:Effect of cell proliferation on healing of gastric and duodenal ulcers in rats. 241 90

This double-blind trial is undertaken to study the effect of rioprostil on the acid and bicarbonate secretion in patients with gastric ulcer. Pentagastrin stimulation is performed before treatment and 9-20 days after the onset of treatment. In the four patients treated with rioprostil, the bicarbonate secretion increases and the parietal volume secretion decreases (p less than 0.05). The eight patients treated with ranitidine do not show an increase in bicarbonate secretion, but the decrease of the basal acid secretion is more prominent. The index of stimulated bicarbonate secretion/maximal acid output increases by 40% in those who are treated with rioprostil. This may be due to an increase in the cytoprotective activity and to a decrease in the aggressive activity of the gastric juice by rioprostil.
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PMID:Effect of rioprostil on the gastric acid and bicarbonate secretion in patients with gastric ulcer. 251 Feb 58

Isolated human gastric glands provide an in vitro model that can yield significant information about the mechanisms regulating gastric acid secretion at the parietal cell level. Aminopyrine, a weak base that accumulates in acid compartments, has been used as an indirect probe of H+ secretion. By means of a microscale technique it was possible to isolate oxyntic glands from gastroscopic biopsy specimens and thereby enable studies of healthy subjects and non-operated ulcer patients. Histamine (5.4 X 10(-5) M) and db-cAMP (10(-3) M) both induced a pronounced response, whereas the response to carbachol (4.5 X 10(-6) M), although still statistically significant, was less potent. The response to stimuli was twice as high in duodenal ulcer patients as in normal individuals. In contrast, the response in patients with a gastric ulcer located either in the prepyloric region or at the minor curvature on the antrum-corpus border was of the same magnitude as in healthy subjects. Pentagastrin did not induce any response in isolated gastric glands from normal individuals. Gastric acid secretion in vitro, measured as aminopyrine accumulation, did not decrease with increasing age of the individuals.
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PMID:Acid secretion in isolated gastric glands from healthy subjects and ulcer patients. 299 68

The effects of the addition of carprofen (Roche), a new nonsteroidal antiinflammatory agent, to regular 4-5 week ranitidine (300 mg/day) therapy on gastric secretion, serum gastrin level and ulcer healing, have been examined in 15 gastric ulcer (GU) and 60 duodenal ulcer (DU) patients. Carprofen at a therapeutic dose (300 mg/day) was well tolerated by both GU and DU patients and did not give rise to any major adverse effects. In an open trial on 15 GU (all receiving carprofen), complete endoscopic ulcer healing was found in 9 patients after 3 weeks and in 6 others after 5 weeks of treatment. In a double blind, placebo controlled trial on 60 DU (30 receiving carprofen and 30 receiving placebo), complete ulcer healing was seen after 2 weeks in 23 on carprofen and 22 on placebo, and after 4 weeks in all tested patients. Pentagastrin-induced maximal acid secretion examined 24 h after the last dose of treatment was significantly reduced in DU, but not in GU, patients, and was accompanied by a significant rise in plasma gastrin levels. No change in gastric histology was observed in any patient tested. This study provides evidence that carprofen added to antiulcer ranitidine therapy shows excellent gastrointestinal tolerance, and does not interfere with ulcer healing; it is, therefore, recommended in the treatment of arthritic patients with peptic ulcer disease.
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PMID:Carprofen and the therapy of gastroduodenal ulcerations by ranitidine. 387 36


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