Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Changes in the contents of various amines and histidine decarboxylase (HDC) activity in the gastric mucosa during the healing process of acetic acid induced gastric ulcer in rats were sequentially examined in the ulcer region and intact region at 2, 10, 40, 80, 180 and 365 days after the operation. The following results were obtained: 1) Histamine (HA) content in the ulcer region was decreased as compared with the intact region at 2 and 10 days and returned to the control level in 40 days. After 180 days, the contents in the ulcer region and intact region were also increased as compared with that of the normal control region. 2) Changes in serotonin (5-HT) content as well as HA content were observed. 3) Norepinephrine content in the ulcer region was decreased as compared with the intact region at 2, 10, 80 and 180 days. 4) HDC activity in the ulcer region was decreased as compared with the intact region at 2, 10 and 40 days, and a lower level was maintained still at 180 days. 5) In the relapse and recurrence of gastric ulcer at 365 days, HA and 5-HT contents in the intact region and ulcer region were not different from those in healing rats, but the contents of these amines were higher at 180 days. The results suggest that the change of HA, 5-HT contents and HDC activity in the gastric mucosa may be one of the factors involved in the relapse and recurrence of chronic ulcers.
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PMID:[Changes in amine contents and regulating enzyme activity of gastric mucosa during the healing process of acetic acid induced ulcer in rats]. 273 3

The experimental Wistar rats were divided into two groups, the acupuncture group and the control group. Stress-induced gastric ulcer models were established by immersion of restrained rats in water. The results are as follows: 1. Stress-induced peptic ulceration was able to be protected with electroacupuncture. 2. Synthesis and decomposition of central and peripheral 5-HT in the electroacupunctured tats was inhibited. 3. The NE levels in the three brain regions (cortex, hypothalamus, brainstem) and blood were seen in the electroacupuncture group more than that in the control group, but the NE levels was smaller in the gastric tissue. 4. The higher levels of DA in the gastric tissue and blood were seen in the electroacupuncture group than in the control group. The results indicated that protecting rat stress ulceration with electroacupuncture was connected with monoamine neurotransmitter of centre and periphery.
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PMID:[Effects of electroacupuncture on central and peripheral monoamine neurotransmitter in the course of protecting rat stress peptic ulcer]. 783 54

Hange-shashin-to (HST) is a traditional Chinese herbal prescription (Banxia Xiexin Tang) which has long been used in the therapy of gastric functional disorders. In this report, the effect of HST extract on water-immersion restraint stress-induced gastric ulcer based on the changes in gastric mucin content and the variations of monoamine contents in hypothalamus were investigated. Ulcer index was microscopically measured by the sum total of the lengths of ulcers in glandular stomach. Gastric mucin content was determined by a PAS-staining methods and the monoamine contents were detected by HPLC-ECD method. HST extract was orally administered at 1, 2 and 3 g/kg for three consecutive days before stress exposure. Water-immersion restraint stress decreased the mucin content and produced gastric ulcers in a restraint time-dependent manner. Pretreatment with HST extract markedly inhibited the reduction of gastric mucin content and the development of gastric ulcer with significant differences (p < or = 0.01). The remarkable decrease of NE and 5-HT contents but prominent increases of MHPG and 5-HIAA contents were observed in hypothalamus after water-immersion restraint stress (p < or = 0.01). Those changes in monoamine contests in hypothalamus were also significantly inhibited by the pretreatment with HST extract at higher dosage (p < or = 0.05). These results indicate that the changes in gastric mucin content and the variation of monoamines in hypothalamus relate to the pathogenesis of water-immersion restraint stress-induced gastric ulcers, and it is suggested that the prophylactic effects of HST extract on stress induced gastric ulcers may be associated with an increase in gastric mucin content, although the prevention of HST extract on the extraordinary changes in monoamine contents in hypothalamus due to stress cannot be ruled out.
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PMID:Protective effects of Hange-shashin-to on water-immersion restraint stress-induced gastric ulcers. 957 80

Stimulation of the sympathetic trunk against the background of the vagus nerve irritation was shown to cause the enhancement of the electromotor activity of the gallbladder, Oddi's sphincter, stomach and duodenum blocked by ganglionary and peripheral serotonin blockers. A lateral-medial gradient of the serotonergic innervation of the biliary tract was revealed. The gastro- and duodenoprotective action of the 5-HT 1,2-serotonin blocker was established at the experimental stomach ulcer.
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PMID:[Serotonergic systems of the biliary tract, stomach and duodenum in the norm and at the experimental stomach ulcer]. 1625 49