Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have previously demonstrated that intracisternal (i.c.) administration of neurotensin (NT), a brain and gastrointestinal tridecapeptide, potently inhibits gastric ulcer formation induced by cold-restraint stress (CRS) in rats. This study evaluated the effect of i.c. NT (17.9 nmol) or vehicle (10 microliter of 0.9% NaCl) on the development of CRS-induced gastric ulcers and on dopamine (DA) concentrations and DA turnover (DOPAC/DA) in selected brain regions after 0, 1, 2 and 3 h of CRS. As anticipated, and in confirmation of previous findings, NT significantly reduced the incidence and severity of CRS gastric ulcers in a time-dependent manner. Neurotensin significantly decreased DA concentration and DA turnover in the striatum. In the nucleus accumbens, however, NT produced a decrease in DA concentration and a concomitant increase in DA turnover after 2 and 3 h of CRS. No significant effects of brain NT on DA concentration and DA turnover were observed in the hypothalamus or olfactory tubercles. These findings suggest that the anti-ulcer effect of brain NT may be mediated, at least in part, by a differential activation of the mesolimbic and nigrostriatal DA systems.
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PMID:Involvement of brain dopamine systems on neurotensin-induced protection against stress gastric lesions. 375 95

Bruxism is generally defined as a parafunctional clenching and grinding action between the upper and lower teeth. During this activity, extremely strong forces can be applied for time periods exceeding those of functional mastication. These biomechanical loads create many dental problems, such as abfractions, hypersensitivity, periodontal distraction, and temporo-mandibular dysfunction. Researchers studying Bruxism have long discussed psychic stress and emotional tension. It has also been indicated that an aggressive biting is associated with a significant attenuation of the stress-induced increase of nor-adrenalin turnover in the brain, of the striatal DOPAC contents and with the prevention of stomach ulcer formation in experimental animals. The concept of stress management based on the psychological background of Bruxism and the benefits attributable to masticatory muscle activity in attenuating stress-related symptoms such as stomach ulcer. The clenching and bruxing function of the masticatory organ is an emergency exit during periods of psychic overloading. Therefore, occlusion of the masticatory organ contributes significantly to an individual's ability to manage stress. Bruxism in proper dentition can be recognized as a valid system prophylaxis for all stress related diseases.
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PMID:[Bruxism--a function of the masticatory organ to cope with stress]. 1567 33