Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anti-ulcer and sedative effects of tranquillosedatives viz. benzodiazepines (diazepam, oxazepam and nitrazepam), barbiturate (phenobarbitone), phenothiazines (chlorpromazine, trifluoperazine and thioridazine) and butyrophenone (haloperidol) were compared in albino rats. Ulceration of the glandular stomach was induced by 2 h restraint at 4 degrees C. Sedation was measured using the rotarod test. These tranquillosedatives showed dose dependent anti-ulcer and sedative effects. The relative potency and therapeutic index (ratio between rotarod ED50 and anti-ulcer ED50) of each drug were determined. Diazepam showed the highest therapeutic index (1.88). Diazepam significantly reduced the volume of gastric secretion, raised its pH and prevented the gastric ulcer formation in pylorus ligated rats but failed to prevent the acute duodenal ulceration induced by intramuscular injection of histamine or carbachol in guinea-pigs and rats, respectively. These observations suggest that benzodiazepines (diazepam) are more suitable anti-ulcer agents compared to barbiturate, phenothiazines and butyrophenone. The anti-ulcer effect of diazepam is possibly due to a combination of sedative, anti-anxiety and antisecretory actions.
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PMID:A study of the anti-ulcer activity of diazepam and other tranquillosedatives in albino rats. 286 Sep 88

Transcranial electrotherapy on the TRANSAIR-02 apparatus of 46 patients with stomach ulcer has been carried out. Sedation of the main symptoms of the disease after 5 procedures was noted in a considerable number of the patients. All the above mentioned symptoms were fully disappeared after 5-7 days of treatment. Using transcranial electrostimulation in complex treatment of the patients with stomach ulcer gives the possibility to decrease the terms oh being present at the station, to decrease the risk of complication and to perfect the quality of treatment.
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PMID:[Application of transcranial electrostimulation in the complex treatment of gastric ulcer]. 2047 96