Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the present study was to explore the relationship between depression (helpless withdrawal behavior) and susceptibility to stress ulcer in rats. The WKY genetic strain of rats has been described as highly susceptible to stomach ulcer development during water restraint, i.e., when placed in a jar of water and forced to swim to keep their head above water, a setting in which Richter identified "giving up" behavior akin to hopelessness (Richter, 1957). Since WKY rats tended to float in the water instead of swimming in an attempt to escape, and were also found to be relatively inactive in open field tests, a series of experiments were performed to ascertain whether their diminished activity and their failure to swim reflected slowness, cognitive impairment, or something actually akin to depression. The latter interpretation was supported by evidence from tests of shock avoidance behavior, of capacity to learn discrimination in an operant setting, and by the capacity of an antidepressive drug to lessen floating time in the forced swim test and also to reduce the incidence of stomach ulcers.
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PMID:Learning behavior, escape behavior, and depression in an ulcer susceptible rat strain. 161 Jul 18

In two prospective studies, including a total of 1,353 and 1,914 male and female participants, a variety of medical and psychosocial risk factors were assessed by means of personal interviews and observational categories. The incidence of gastric cancer was determined for the following study groups: 1) all persons with chronic atrophic gastritis and pernicious anemia who had one to three relatives with a history of gastric cancer, 2) persons with a previous operation for gastric ulcer (partial resection) and one to three relatives with gastric cancer, and 3) a comparable group without any of these characteristics, serving as a reference. The hypothesis was that significantly more gastric cancer was to be expected in groups 1 and 2. A second hypothesis was that interaction between the specific precursors and psychosocial risk factors (chronic hopelessness due to withdrawing objects) was useful for the prediction of gastric cancer. The results may open new avenues for the prevention of gastric cancer via preventive psychotherapy in identified risk groups.
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PMID:Precursor lesions of the GI tract and psychosocial risk factors for prediction and prevention of gastric cancer. 322 43

In this paper the author aims to evaluate theories of onset conditions both before psychological and before somatic symptoms by the first ever clinical-quantitative assessment of their preconditions, and then to compare these preconditions with Freud (1926) and with other theories of symptom formation. The seven cases in the sample were the only cases of recorded psychotherapy or psychoanalysis, each with recurrent symptoms in segments of sessions before symptoms versus segments of sessions before controls (with no symptoms) that were suitable for 'the symptom-context method'. The recurrent psychological symptom cases were: momentary forgettings, depressive shifts, and phobic feelings and behaviours; the recurrent somatic symptoms were stomach ulcer pains, migraine headaches, absence (petit mal) episodes and premature ventricular contractions (PVC) of the heart. Independent ratings of pre-symptom segments versus pre-control segments showed significant differences in all seven cases. Many emotional state qualities differentiating the pre-symptom from the pre-control segments were similar across cases. These were, in rank order, hopelessness, lack of control, anxiety, feeling blocked, helplessness, concern about 'supplies', depression, hostility to therapist, guilt, involvement with therapist, separation concern and hostility to others. For example, hopelessness significantly differentiated pre-symptom versus pre-control for all seven cases. For the first time, samples of segments of sessions before recurrent symptoms have been both clinically and quantitatively compared with segments without symptoms. Brief segments before recurrent symptoms showed significantly more of certain qualities than brief segments before controls where no symptoms appeared. These qualities led to the author's revised symptom-context theory of symptom formation and then to a comparison with five classical theories of symptom formation.
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PMID:The only clinical and quantitative study since Freud of the preconditions for recurrent symptoms during psychotherapy and psychoanalysis. 1180 87