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Disease
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Enzyme
Compound
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Target Concepts:
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Query: UMLS:C0038358 (
gastric ulcer
)
5,179
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The healing of gastric ulcers requires not only the complete epithelial covering but also the restitution of connective tissue. Transforming growth factor-beta (TGF-beta) and its downstream mediator,
connective tissue growth factor
(
CTGF
), are potent stimulators for connective tissue formation during wound healing. The expression of TGF-beta,
CTGF
and type III collagen mRNA in indomethacin-induced gastric ulcers in rat, was investigated by Northern blot analysis. We also examined the localization of
CTGF
producing cells by in situ hybridization. Northern blot analysis showed expression of TGF-beta mRNA on days 1 and 3 after indomethacin administration, expression of
CTGF
mRNA on days 1, 3 and 7 and type III collagen mRNA expression on days 1, 3, 7 and 12, respectively. Control animals showed no expression of TGF-beta,
CTGF
or type III collagen mRNA. In situ hybridization showed
CTGF
mRNA positive cells on days 1, 3 and 7 after ulcer induction in fibroblast-like cells and in some of the blood vessels. Thus our findings indicate that growth factor
CTGF
, together with TGF-beta, participates in
gastric ulcer
healing by regulating connective tissue formation and angiogenesis. These results are compatible with the role of
CTGF
as a downstream mediator of TGF-beta effects.
...
PMID:Connective tissue growth factor in indomethacin-induced rat gastric ulcer. 1207 10
