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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Treatment of gastric peptic ulcerations, which requires both medical and surgical coordination in its management, is a complex subject. Despite advances in the medical therapy of ulcers, medications have little impact on the course of bleeding peptic ulceration. Newer endoscopic techniques of injection with adrenaline or alcohol, heater probes, and vicaps electrodes have controlled bleeding in many patients. Still, a subset of patients remains who will require surgical interventions with gastrotomy and oversewing of the ulcer crater. We describe a new technique for management of the acute gastric ulcer bleeding that avoids gastrotomy and potential contamination in the post-transplant patient.
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PMID:Simultaneous laparotomy and endoscopy for control of bleeding gastric ulcerations after liver transplantation without enterotomy. 134 19

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to increase the risk of gastrointestinal injury including gastric ulcer. Topical injury under low pH environment and cyclooxygenase-1 (COX-1) inhibition resulting in gastric prostaglandin (PG) suppression are two main mechanisms of gastric damage. Topical injury can be avoided by prodrug which is activated after absorption or alter drug administration route such as suppository. But, gastric injury by PG suppression cannot be avoided even by such contrivances. Use of selective COX-2 inhibitor is another way to reduce gastric injury and certain effect is already established. However, least expected side effect of cardiovascular damage was identified by selective COX-2 inhibitor. Still NSAIDs are effective and applicable for many diseases. Numbers of prescription for aged patients are increasing. Physicians should percept the mechanism of effect and side effect of NSAIDs, and exert their best to avoid side effects of NSAIDs.
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PMID:[NSAIDs and its gastrointestinal side effects: relation of NSAIDs variety and influence of concomitant medicine]. 1792 23