Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since 1946, 20 men and one woman aged 40 to 76 years (average 57) were operated upon for complications of diospyrobezoars. Shortly after eating persimmons, 11 (52.4%) had severe abdominal cramping, anusea, vomiting, and pyrexia. Twelve of 17 (70.9%) with gastric bezoars had hematemesis or melena caused by an associated gastric ulcer, while five (29.1%) had only moderate dyspepsia. In four (19.1%), the bezoar had lodged in the ileum, causing obstruction. Enzymatic therapy is indicated in those with minor symptoms. Gastrotomy or gastrotomy with bezoar removal and wedge resection of the gastric ulcer is recommended when enzymatic therapy fails, or when there is gastric outlet obstruction or marrise hemorrhage. Emergency exploration with removal is necessary when the persimmon bezoar causes ileal obstruction.
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PMID:Management of persimmon bezoars (diospyrobezoars). 51 61

The medical treatment of gastric ulcers is essentially based on the administration of H2 antagonists such as cimetidine and ranitidine and antacids. A case of gastric bezoar which developed forty-five days after medical treatment for gastric ulcer of the smaller curvature is described.
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PMID:[Formation of a gastric bezoar following upper digestive hemorrhage caused by a medically-treated ulcer]. 609 31

A clinical case of bezoar of the stomach accompanied by peptic and gastric ulcer is presented. The different types of bezoar and the reasons for their formation are described, and the clinical, laparotomic and anatomopathological picture is illustrated.
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PMID:[Bezoar of the stomach. Clinical case report]. 736 Mar 44

An esophageal bezoar occurring in a young patient without esophageal abnormality is described. The history of severe progressive dysphagia following forceful vomiting and presence of a gastric ulcer suggest that the esophageal bezoar might have originated in the stomach.
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PMID:Bezoar of the esophagus. 741 92

The soft phytobezoars occurring in the postoperative stomach may be readily removed by enzyme digestion and manipulation. In contrast, the persimmon bezoar (diospyrobezoar) has been persistently to such treatment and has required surgical removal. Experience with unsuccessful attempts at enzyme digestion in a number of such patients led to the experimental use of a "soaking" technic which satisfactorily dissolved two of three large persimmon bezoars and shrank the remaining foreign body sufficiently so that it could be removed endoscopically by way of the esophagus. A concomitant gastric ulcer healed uneventfully on medical therapy.
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PMID:Nonoperative management of persimmon bezoar. A successful modification of traditional papain therapy. 746 63

Gastric bezoars may be formed in the stomach as a result of foreign body accumulation with inability to pass through the pylorus. Usually bezoars are found in patients with a history of previous gastric surgery. Phytobezoars are the most common type of bezoars. Major complications of bezoars include intestinal obstruction, gastric ulcer, gastric perforation, and bleeding. We present the case of a 51-year-old woman with the features of gastrointestinal bleeding due to a giant diospyrobezoar in the stomach. During endoscopy besides the bezoar, a giant acute ulcer was found. Histological examination of biopsy specimens from ulcer area revealed changes typical of superficial ischemic damage due to prolonged bezoar compression. The patient had undergone a vagotomy and pyloroplasty 13 years ago, and she used to eat two or three persimmons per week during the last six months. The bezoar was fragmented during two endoscopies, and the fragments drifted away through the intestine. We conclude that delayed gastric emptying due to previous gastric surgery and regular eating of persimmons caused the formation of a giant bezoar with ischemic ulcer of gastric mucosa and bleeding. Such pathology potentially could be prevented by dietary advice.
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PMID:An unusual case of bleeding from stomach due to a giant diospyrobezoar. 1960 68