Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A community-based group of gastroenterologists examined 623 patients (541 prospectively and 82 retrospectively) with endoscopically diagnosed gastric ulcer disease during a 12-month period. Patients averaged 60 years of age; the majority were women (62%). Women were less likely to smoke, abuse alcohol, and were more likely to present with abdominal pain (p less than 0.05). Whereas patients presenting with bleeding or requiring transfusion were less likely to complain of pain (p less than 0.05), they were more likely to be taking aspirin or nonsteroidal anti-inflammatory drugs and have prior history of bleeding (p less than 0.05). Patients with a prior history of ulcer disease were more likely to smoke, present with pain and use acetaminophen (p less than 0.05). Patients with large ulcers were more likely to bleed, present with pain, and obstruct (p less than 0.05). Multiple gastric ulcers were seen in patients taking aspirin or nonsteroidal anti-inflammatory drugs (p less than 0.05).
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PMID:Studies of gastric ulcer disease by community-based gastroenterologists. 237 83

Panendoscopy was analysed prospectively on 1635 patients in a personal series for the years 1976 to 1979, under standard conditions, including for emergency bleeding. 48% of males showed lesions, compared with 38% of females. Important diseases were uncommon under 40 years of age, except for reflux disease of the oesophagus. Duodenal ulcer craters exceeded gastric ulcers in the ratio of 1.6 to 1.0. The 103 chronic gastric ulcers were analysed according to gender (male to female ratio 1.6 to 1.0), age (only 4% were seen under the age of 40), diameter and location (larger ulcers were more common in the body of the stomach than the antrum). Multiple gastric ulcers occurred in 9 patients, while pyloroduodenal ulcers coexisted with gastric ulcer in 7. Duodenal ulcers seen in 164 patients were multiple in 12; only 4% occurred under 30 years of age. The duodenal ulcer male to female ratio for Europeans was 2.5 to 1.0. Cancer of the stomach was uncommon (36 patients). Reflux oesophageal disease (182 patients) was the most common disorder diagnosed endoscopically. The commonest lesions found in acute bleeding (174 patients) were duodenal ulcer in 19%, gastric ulcer in 11%, oesophageal erosions 17% and gastroduodenal erosions in 17%.
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PMID:Endoscopy in peptic diseases and bleeding: a community survey of 1635 patients. 338 Apr 37