Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In spite of reduction in mortality, gastric carcinoma is still one of the most frequent types of carcinoma. For this reason precanceroses - pernicious anemia and diffuse adenomatous polyposis of the stomach - must be particularly watched. Whether gastric ulcer and chronic gastritis are precanceroses is discussed. Clinical aspects, therapy and prognosis are described in detail.
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PMID:[Gastric carcinoma (author's transl)]. 81 83

The effectiveness of a fluorescent analysis in the diagnosis of gastric cancer was studied in 280 patients. Fluorescence of a tumor was noted in 87% of cases. Dependence of fluorescence of a tumor on its sizes was revealed: in tumor diameter less than 1 cm, fluorescence was revealed in 94% of cases, more than 4 cm--in 76%. In infiltrative growth, only 74% of tumors were fluorescent. To define the possibility of the use of a fluorescent analysis in the differential diagnosis of gastric diseases, 490 patients with presumptive diagnosis of chronic gastritis, gastric ulcer disease, polyposis were examined. In diagnosis of +malignant polyps in 91.5% of cases, results of the fluorescent analysis concurred with the findings of histologic study. Probability of establishing the correct diagnosis by the data of fluorescent analysis in ulcer disease is equal to 87.5%, in chronic gastritis--86%.
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PMID:[Use of the fluorescent analysis in early diagnosis of cancer of the stomach]. 138 May 85

Tumor-associated trypsin inhibitor (TATI) was assayed in serum of patients with gastroenterological diseases. Of the patients 92 had gastric cancer, 50 colonic cancer, 38 colitis, 36 polyposis of the colon, and 40 gastric ulcer. The cut-off level established on the basis of the mean concentration +3 SD of a reference population comprising 120 subjects was 32 micrograms/l. In gastric cancer TATI had a sensitivity and specificity similar to that of CA19-9, whereas its behavior in colon cancer was less satisfactory. Like other tumor markers TATI may be elevated in patients with inflammatory diseases. In our opinion TATI is a good tumor marker for gastric cancer and it is a useful complement to CEA and CA19-9.
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PMID:Tumor-associated trypsin inhibitor, TATI, in gastrointestinal cancer and related benign diseases. 178 Jun 97

The presence of Campylobacter pylori was studied in biopsy material from gastric mucosa taken by guided biopsy during fiber gastroduodenoscopy from 101 patients with chronic gastritis (n = 50), peptic gastric ulcer (n = 28), peptic duodenal ulcer (n = 7), gastric cancer (n = 10) and gastric polyposis (n = 6). Campylobacter pylori was found in various quantity--moderate (++) and considerable ( )--in 64% of the patients with chronic gastritis, in 85.7% of the patients with peptic gastric ulcer and in 100% of the patients with peptic duodenal ulcer as well as in half of the patients with gastric cancer and polyposis. The quantity of Campylobacter pylori correlated with the severity of the inflammatory process and the degree of atrophy of the gastric antral mucosa. A tendency toward seasonal incidence of Campylobacter pylori infection of gastric mucosa was established: 78.69% of the patients examined during spring time (April-May) and 60.0% of the patients examined during winter time (January-February) had Campylobacter pylori infection. This explains to a certain extent the seasonal exacerbations of the pathological process in chronic gastritis and peptic ulcer. The development of a well expressed chronic atrophic gastritis is in direct relation with the greater quantity of Campylobacter pylori in the gastric mucosa. The study reveals the pathogenetic relations between the presence and quantity of Campylobacter pylori and the development and evolution of chronic gastritis and peptic gastric and duodenal ulcer.
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PMID:[Campylobacter pylori in patients with chronic gastritis and gastric and duodenal peptic ulcer]. 276 25

Radioimmunologic procedures were employed in comparing the levels of carcino-embryonic antigen in the gastric juice, blood plasma and saliva in cases of stomach cancer, gastritis, polyposis and gastric ulcer. No correlation between the antigen levels in different biological fluids was established. It was found, however, that the assay of carcino-embryonic antigen level in gastric juice may be instrumental in detecting precancerous lesions of the stomach.
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PMID:[Use of the carcinoembryonic antigen in the gastric juice for diagnosing pretumorous stomach diseases]. 402 56

Seven cases of pneumatosis cystoides intestinalis affecting the colon (PKC) revealed 5 times by a nonspecific symtomatology and 2 times by an occlusion were reported. In three of the patients the disease was found as a primary idiopathic form free of clinical antecedents. In 4 of the patients the pneumatosis was found to be secondary to a pulmonary disease, a gastric ulcer, a connectivite of a corticotherapy. The PKC was generally diagnosed either by barium enema or by computed tomography and less frequently by colonoscopy with deep biopsy allowing differential diagnosis with colonic polyposis. The mechanism and etiology of the PKC were not fully understood. The illness is a benign condition that often responds to a conservative management--i.e. abstention, oxygenotherapy, diet or antibiotherapy- or exceptionally to surgical colonic resection in case of acute complication.
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PMID:[Pneumatosis cystoides of the colon. Apropos of 7 cases]. 961 88

In a population-based case-control study of pancreatic cancer conducted in three areas of the USA, 484 cases and 2099 controls were interviewed to evaluate the aetiologic role of several medical conditions/interventions, including diabetes mellitus, cholecystectomy, ulcer/gastrectomy and allergic states. We also evaluated risk associated with family history of cancer. Our findings support previous studies indicating that diabetes is a risk factor for pancreatic cancer, as well as a possible complication of the tumour. A significant positive trend in risk with increasing years prior to diagnosis of pancreatic cancer was apparent (P-value for test of trend = 0.016), with diabetics diagnosed at least 10 years prior to diagnosis having a significant 50% increased risk. Those treated with insulin had risks similar to those not treated with insulin (odds ratio (OR) = 1.6 and 1.5 respectively), and no trend in risk was associated with increasing duration of insulin treatment. Cholecystectomy also appeared to be a risk factor, as well as a consequence of the malignancy. Subjects with a cholecystectomy at least 20 years prior to the diagnosis of pancreatic cancer experienced a 70% increased risk, which was marginally significant. In contrast, subjects with a history of duodenal or gastric ulcer had little or no elevated risk (OR = 1.2; confidence interval = 0.9-1.6). Those treated by gastrectomy had the same risk as those not receiving surgery, providing little support for the hypothesis that gastrectomy is a risk factor for pancreatic cancer. A significant 40% reduced risk was associated with hay fever, a non-significant 50% decreased risk with allergies to animals, and a non-significant 40% reduced risk with allergies to dust/moulds. These associations, however, may be due to chance since no risk reductions were apparent for asthma or several other types of allergies. In addition, we observed significantly increased risks for subjects reporting a first-degree relative with cancers of the pancreas (OR = 3.2), colon (OR = 1.7) or ovary (OR = 5.3) and non-significantly increased risks for cancers of the endometrium (OR = 1.5) or breast (OR = 1.3). The pattern is consistent with the familial predisposition reported for pancreatic cancer and with the array of tumours associated with hereditary non-polyposis colon cancer.
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PMID:Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. 1046 6

Results of clinical and instrumental-laboratory study of 17 cases are presented. According to the rapid urease test (CLO) and histological studies, the helicobacter infection was found in 12 (70.6%) cases out of the group of 17 suffering from chronic atrophic gastritis, gastric ulcer adenomatous polyposis. Analyses of Helicobacter pylori dissemination over the gastric mucosa manifested the I (weak) degree (up to 20 microbes within field of vision) prevailing in 8 (66.7%) of 12 cases, while the II (medium) degree (up to 50 microbes within field of vision) and III (high) degree (over 50 microbes within field of vision) occurred only in 4 cases (33.3%). By comparative cytogenetic research of the peripheral blood lymphocytes we found the immunogenetic markers and characteristic features of cytogenetic disturbances in the immunocompetent cells in cases of pre-cancer Helicobacter pylori-associated diseases (chronic atrophic gastritis, gastric ulcer, adenomatous polyposis). Statistical data confirmed an increase in the percentage of cells with chromosomal aberrations, which amounted to 4.25+/-0.51 in the chronic atrophic gastritis cases, 3.5+/-0.46 in the gastric ulcer cases, 5.75+/-0.60 in the adenomatous polyposis cases for 100 analyzed metaphases. Considering the questionable role of Helicobacter pylori as a direct initiator of mutagenesis, the immune disturbances may be caused by the damage of DNA of lymphocytes resulting from the genotoxic effect of some intermediates of inflammation.
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PMID:[Chromosomal instability of peripheral blood lymphocytes in patients with precancer gastric cases]. 1698 Jul 44