Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunohistochemical staining was performed by the ABC method using antibody against S100 protein for the identification of dendritic cells (DC) in the gastric mucosa, including gastric ulcer (n = 19), chronic atrophic gastritis (n = 28), gastric carcinoma (n = 65), fetal gastric mucosa (n = 11) and normal controls (n = 15). Lower numbers of DC may indicate an antigen-deficient state in normal and fetal gastric mucosa, while the diverse densities of DC in pathological conditions may reflect the differences in antigenic quantities and qualities and in individual immune responses. The close association between DC and lymphocytes in situ suggest an antigen-presenting capacity of DC controlling the activation of lymphocytes.
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PMID:[Immunohistochemical characterization of S100 proteinpositive dendritic cells in gastric mucosa]. 215 93

Quantitative analysis of dendritic cells (DC's) was carried out in tissue specimens of normal gastric mucosa (n = 15), gastric ulcer (n = 19), chronic atrophic gastritis (n = 28), and gastric carcinoma (n = 65) by ABC immunostaining with S100 protein antibody. Significant increases in DC number were observed in chronic atrophic gastritis with type III intestinal metaplasia and/or grade II, III dysplasia. The result suggests that DC's are potentially capable of presenting neoantigens associated with malignant transformation at the precancerous stage when malignant morphological changes have not yet taken place. Combined with routine diagnostic methods, the serial monitoring of DC density in gastric mucosa may be useful in the follow-up of premalignant lesions in the stomach and the diagnosis of early gastric carcinoma.
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PMID:S100 protein-positive dendritic cells and the significance of their density in gastric precancerous lesions. 224 39

Malignant melanoma involving the gastrointestinal tract is diagnosed antemortem in only a small percentage of patients with the disease. Presenting symptoms are often non-specific, causing a diagnostic problem. The vast majority of such melanomas are metastatic from a cutaneous primary, however there is evidence that the tumour can arise de novo in the gastrointestinal system. We report a 74-year-old man with malignant melanoma with an unusual presentation simulating a symptomatic gastric ulcer. He presented with epigastric pain, haematemesis and melaena. Explorative laparotomy revealed a large ulcerated tumour with several pigmented satellite nodules in the proximal stomach, multiple ileal nodules and widespread nodal and liver metastases. Proximal gastrectomy and limited small bowel resection was performed. Histology revealed the tumour to be composed of nests of epithelioid cells with melanin pigment. The tumour cells showed immunohistochemical positivity for S100 protein and HMB45 antibodies. This report emphasizes that melanoma should be a diagnostic consideration in patients with gastric ulcer.
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PMID:Malignant melanoma of the gastrointestinal tract presenting as a bleeding gastric ulcer. 1619 79