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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twelve cases of peptic ulcer with diabetes mellitus were found in 165 hospitalized diabetics. All of them had gastric ulcer and no duodenal ulcers were found. The incidence of peptic ulcer in diabetics was comparatively higher than the previously reported series. But there was nosignificant correlation between the duration of diabetes and the onset of gastric ulcer. The gastric ulcer with poorly controlled diabetes showed more intractability than those without triopathy and well-controlled diabetes.
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PMID:Peptic ulcer in diabetes mellitus. 97 82

In the light of an analysis of late results of surgical treatment obtained in a group of 2450 patients with chronic gastric or duodenal ulcer subjected to various types of operations the author stresses the importance of choice of a proper surgical method. It is concluded that in treatment of chronic gastric ulcer the most appropriate method is partial gastrectomy including the whole pyloric part of the stomach. On the other hand, in chronic duodenal ulcer gastrectomy must be more extensive including over 70% of the gastric surface, it may be less extensive if associated with vagotomy. Truncal vagotomy with pyloroplasty should be applied only in high-risk patients in view of a high proportion of recurrences of peptic ulcer.
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PMID:Choice of surgical method in treatment of chronic gastric and duodenal ulcer. 99 48

Microscopic lesions of the gastric arteries have been studied in 21 patients subjected to resection for gastroduodenal ulcer. The left gastric artery, particularly in patients with gastric ulcer, presents lesions to the intima and media and these can lead to obliteration of the lumen, classifiable as atherosclerotic disease. The seriousness of the lesions would seem to be independent of sex and age. In some cases gastric artery lesions were compared with those to the arterioles in the vicinity of the ulcer. At least as far as the gastric district is concerned, there would not appear to be any gravity correlation between large and small vessels. Some aspects of the vascular pathogenesis of gastroduodenal ulcer are discussed.
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PMID:[Morphological studies of gastric arteries in patients with gastro-duodenal ulcer]. 100 94

Age incidence, food habits and socio-economic condition were studied in a series of 478 predominantly male peptic ulcer patients. Age incidence of peptic ulcer increased in the second decade of life, reached a peak at the third decade and tapered off towards the end of fourth decade. As many as 57% of the patients belonged to the low socio-economic group and 78% were having only two meals a day. A ratio of 21 : 1 for duodenal ulcer to gastric ulcer was revealed from laparotomy findings.
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PMID:Peptic ulcer: (Analysis of predisposing and associated causes). 103 75

During 2 1/2 year period in Port Moresby General Hospital, 1023 patients had barium meals. Two-thirds of the patients were males and over half were expatriates. Positive findings were noted in 26% of Papua New Guineans but only 11% of expatriates. Over half of those with positive findings had peptic ulcer. Chronic duodenal ulcer, including deformed duodenal cap, was the commonest finding in both Papua New Guineans and expatriates but gastric ulcer was also common in Papua New Guinean males. The incidence of peptic ulcer is less than that reported in Goroka and in some other countries. The next commonest findings were carcinoma of the oesophagus and stomach in Papua New Guineans and hiatus hernia in expatriate males.
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PMID:A radiological survey of upper gastrointestinal lesions in Port Moresby 1972-74. 107 69

To confirm the reported lack of major gastrointestinal side effects of naproxen, we gave 58 patients with active rheumatoid arthritis and significant gastrointestinal disease therapeutic doses of naproxen while closely monitoring them for signs and symptoms of gastrointestinal dysfunction. All patients underwent upper gastrointestinal x-ray examinations at the start of the trail, and, when indicated, during the course of the study. Endoscopies were also performed when indicated. Forty patients had hiatus hernia and 35 had peptic ulcer (23 duodenal ulcer and 12 gastric ulcer). Twenty-six patients had a combination of hiatus hernia with either type of peptic ulcer. After 262 patient visits over a period of 52 weeks, 35 patients remained in the study, all having had more than six months of naproxen therapy in dosages ranging from 500 to 750 mg daily. In 33 of the 35, the response to naproxen had generally been good to excellent. Only seven patients dropped out of the trial because of complaints referable to side effects. There were no major related upper gastrointestinal side effects as monitored by continuing clinical evaluation, stool occult blood, comprehensive laboratory examination, and, where indicated, upper gastrointestinal x-ray studies. Approximately 70 per cent of the patients demonstrated efficacy on long-term naproxen therapy by subjective and objective parameters. Naproxen appears to be an efficacious and remarkably safe drug in the long-term therapy of rheumatoid arthritis, even in the presence of significant upper gastrointestinal symptomatology.
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PMID:An open trial of naproxen in rheumatoid arthritis patients with significant esophageal, gastric, and duodenal lesions. 109 32

Soya bean milk was given orally in doses of 150 ml second-hourly (7 a.m. to 11 p.m. daily) to 10 Chinese subjects with proven gastric ulcer for two weeks. The control group consisted of 10 Chinese subjects with proven gastric ulcer who did not receive soya bean milk therapy. All were inpatients and were given bed rest. Gastric ulcer healing was assessed endoscopically with a duodenofibrescope. Endoscopic visualization and colour photography of the ulcer crater were undertaken just before and after two weeks of treatment. In the soya bean milk group, complete healing was seen in two cases, considerable healing in four cases, slight healing in two cases, and no healing in two cases. In the control group, complete healing was seen in no cases, considerably healing in three cases, slight healing in four cases, and no healing in three cases. The mean ulcer healing grade was 1.600 in the soya bean milk group as compared with 1.000 in the controls. The difference was not statistically significant. There was no significant difference between the two groups in the initial ulcer size, age and sex distribution. Although the effect on gastric ulcer healing was not significant, soya bean milk has been shown to be effective in the relief of peptic ulcer pain.
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PMID:Effect of soya bean milk on the healing of gastric ulcers -- a controlled endoscopic study. 109 66

Stepwise increasing doses of pentagastrin (0.166, 1, and 6 mug/kg-hr) were given to 21 healthy volunteers (HV), 22 patients without peptic ulcer disease (MI), and 22, 18, and 19 patients with duodenal (DU), pyloric (PU), and gastric ulcer (GU) respectively. Maximal response (Vmax) and half maximal dose of pentagastrin (Km) were calculated for both acid and pepsin. The ability to secrete acid and pepsin was in PU and GU slightly higher and lower, respectively, than in the non-ulcer groups. Markedly elevated values were found in DU, and the pepsin secretion was relatively more increased than that of acid. The values for Km suggested a different behavior of the chief cells and the parietal cells in DU. Whereas the sensitivity of the parietal cells appeared to be abnormally high, that of the chief cells tended to be lower than normal. The discrimination between DU and the non-ulcer groups was better by estimation of pepsin than of acid secretion and tended to improve with increasing stimulation. Superiority was however, found for a submaximal dose of pentagastrin for acid secretion. No superiority in discrimination between groups was found for Vmax. Km was poorly reproducible for acid and pepsin and showed little diagnostic significance. The study suggests that pentagastrin dose-response does not provide more diagnostic information than a single dose (1 mug/kg-hr), which is maximal for pepsin and submaximal for acid.
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PMID:Pentagastrin dose-response in peptic ulcer disease. 110 72

Serum group I pepsinogen (PG I) levels have been determined by radioimmunoassay in 924 subjects. The mean levels in 300 healthy control subjects and in 389 hospitalized controls were 110.6 and 100.0 ng per ml, respectively. The "normal" range is estimated to be between 50 and 175 ng per ml. The mean level of serum PG I in 7 patients with Zollinger-Ellison syndrome was 503.9 ng per ml; values ranged between 315 and 921 ng per ml. The 77 patients with duodenal ulcer had a mean serum PG I level of 221.3 ng per ml; 49 (63.6%) had values greater than 175 ng per ml. The distribution of serum PG I values was bimodal in the patients with duodenal ulcer whereas it was unimodal in both groups of control subjects. Mean serum PG I levels in 13 patients with both duodenal and gastric ulcer and in 18 patients with prepyloric ulcer were, respectively, 177.2 and 179.4 ng per ml. Approximately one-half of these patients had high values. The 28 patients with gastric ulcer had a mean serum PG I level of 116.6 ng per ml; 6 (21.4%) had high values. With the exception of 3 patients with gastric ulcer, none of the 136 patients with peptic ulcer had a low (less than 50 ng per ml) level of serum PG I. In 37 patients with chronic alcoholism the mean level of serum PG I was 73.4 ng per ml. The observed gradient in the mean level of serum PG I among the groups of patients studied is similar to that which has been reported for maximally stimulated gastric acid output. This finding suggests that the secretory potential of the fundic gland mucosa of the stomach may be reflected by the level of PG I in serum.
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PMID:Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer. 115 38

The gastric acid secretion in response to graded antral distension was determined in healthy subjects and in peptic ulcer patients with water perfusion or alkaline buffer perfusion of the stomach, giving an intragastric pH of 1.8-3.0 and 6.2-8.3 respectively. Intragastric neutralization increased the basal acid secretion in healthy subjects and gastric ulcer patients but did not change the basal acid secretion in duodenal ulcer patients. Distension of the antrum produced the same secretory effect with and without intragastric neutralization: no increased acid response in healthy subjects, a slight acid response in patients with a quiescent duodenal ulcer or a gastric ulcer, and a more pronounced acid response in patients with an active ulcer, amounting to about 30% of the peak acid response to pentagastrin. The results show that: a) the peptic ulcer patients - and particularly patients with an active duodenal ulcer - are more sensitive to the acid secretory effect of antral distension than healthy subjects; b) increasing the intragastric pH above 20 does not enhance the acid response to antral distension; c) the acid secretory effect of antral distension is markedly less in man than the effect observed in the dog.
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PMID:The effect of intragastric neutralization on the gastric acid response to antral distension in man. 117 56


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