Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relationship between chronic gastritis and peptic ulcer was studied in 97 patients, 51 with duodenal ulcer and 46 with gastric ulcer. Six biopsies (three from the antrum and three from the body) were obtained under direct vision by means of an Olympus panendoscope. Chronic gastritis was classified according to the grade of inflammation (slight or moderate and intense), and to its location (antritis or pangastritis). In gastric ulcer the relationship between frequency of chronic gastritis and the site of the ulcer (antrapyloric, at the angulus, body of the stomach) was also established. Antritis was just as frequently observed in duodenal ulcer (94%) as in gastric patients (96%), but severe inflammation of the antrum was higher in G.U. (43%) than in D.U. (17%). Chronic gastritis of the gastric body was always accompanied by antritis, both in G.U. and in D.U. and was observed in 63% of the former group and 37% of the latter. Severe inflammation of the glandular portion of the stomach occurred in only one patient with D.U (2%) and in 7 with G. U (15%). In the present investigation, no relationship between between the site of gastric ulcer and the frequency of chronic gastritis was observed.
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PMID:Chronic gastritis and peptic ulcer. 93 May 40

We have assessed 270 consecutive patients (age range 0.8-20 years) referred for endoscopic study because of abdominal pain during 32 months. Helicobacter pylori (HP) was detected by culture in 91 cases (33.7%). HP colonization increased significantly with age (p less than 0.01). Nine patients less than 5 years of age were colonized by HP. A previous history of peptic ulcer disease in first-degree relatives was significantly more frequent in the HP-positive group (p less than 0.001). The frequency of HP positiveness as related to diagnosis was: normal, 3.3%; nonactive chronic gastritis, 100%; active chronic gastritis, 97.2%; gastric ulcer, 75%; and duodenal ulcer, 90.9% (p less than 0.001). Endoscopic nodular antritis was a frequent (67%) and specific finding; this presence was associated with that of lymphoid follicles in the histopathological study. Signs of histological activity were observed in 55.9% of the HP-positive patients. The histological colonization by HP was assessed semiquantitatively, and a significantly greater HP colonization score was observed in patients with signs of histological activity (p less than 0.001). A significant correlation was found between HP colonization score and histological score (rs = 0.574), with a significant association between the degree of HP colonization and the histologic categories (p less than 0.001). The present study suggests a pathogenic role of HP in the development of gastroduodenal disease in children.
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PMID:Helicobacter pylori infection in children: clinical, endoscopic, and histologic correlations. 835 Feb 6