Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Surface electrogastrograms were recorded in 95 patients. There were 6 groups of patients: chronic superficial gastritis (20), chronic atrophic gastritis (20), duodenal ulcer (20), gastric ulcer (17), gastric cancer (8), and diabetes mellitus (10). Electrogastrographic examination was continuously carried out for 60 minutes both in fasting and postprandial state. (1) During the fasting state, in 72% of the cases, there was a 50% to 100% change in the mean of the amplitude among six 10-minute periods of recording. (2) In 23 cases (25%), there was no amplitude increase in the postprandial electrogastrogram. Feeding caused an increase in amplitude by 30-240 microV over the prefeeding state in 70 cases (75%). (3) The distribution of amplitude in various groups of disease overlapped each other. The difference in amplitude or frequency would not be used as a diagnostic parameter of gastric diseases. (4) Tachygastria of 5-7.3 cycles per minute was observed in 15 of the 95 patients. The longest episode was a wave with 7.3 cycles per minute lasting for 20 minutes. It is difficult to evaluate the clinical significance of the observed tachygastria.
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PMID:[Electrogastrography: the clinical significance of changes during fasting and postprandial state]. 191 65

We compared the prevalence rates of peptic ulcer (duodenal and gastric) and gastric cancer in 1,796 dyspeptic Peruvian patients with those reported in 2,883 similar patients from developed countries. The prevalence of total peptic ulcer was significantly lower, and that of gastric cancer significantly higher, in the Peruvian patients. The prevalence of gastric ulcer was lower but not significantly so. We deduced that the significantly lower prevalence of total peptic ulcer was directly related to the low prevalence rate of duodenal ulcer. We hypothesize that the reason for these differences was probably a higher prevalence of Helicobacter pylori-associated chronic atrophic gastritis with hypochlorhydria in the Peruvian patients. Hypochlorhydria decreases the predisposition to peptic ulcer (especially duodenal ulcer), and chronic atrophic gastritis may predispose an individual to gastric cancer.
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PMID:Low peptic ulcer and high gastric cancer prevalence in a developing country with a high prevalence of infection by Helicobacter pylori. 203 22

In order to investigate the healing process of gastric ulcer, cell proliferation kinetics of the regenerative mucosa over gastric ulcers was studied by an in vitro bromodeoxyuridine (BrdU)-anti BrdU method. In addition, the effect of histamine H2 receptor antagonists on gastric cell kinetics was also studied. The BrdU labeling index (L.I.) at the site ulcer margin, which were determined by the ratio of labeled cells to epithelial cells of gastric mucosa, were significantly higher in cases of endoscopic A to S1 stage ulcer than in cases of the atrophic gastritis served as control. While the mean L.I. of surrounding mucosa, approximately 1 cm apart from the ulcer margin, in the stage A to S1 were also significantly higher than that of control, the value in the stage S2 was almost comparable to the value of control. There were no differences of L.I. between the cases treated with and without H2 receptor antagonists. These results suggest that in the healing process of ulcer not only reserved epithelial cells at the ulcer margin but also the cells apart from the margin participate in mucosal regeneration. And it seems advisable to consider the stage S2 rather than the stage S1 as the most precise healing stage of ulcer. H2 receptor antagonist may not give an influence on proliferative properties of regenerating mucosal epithelium.
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PMID:[S phase cells of regenerative epithelium in the healing process of gastric ulcer determined by an in vitro BrdU-anti BrdU method]. 204 49

Investigations were carried out as to whether a disturbance in the formation of cytoprotective prostaglandin (PG) E2 in gastric mucosa is implicated in chronic renal failure. PGE2-like immunoactivity in gastric mucosal specimens was measured in individuals with chronic renal failure (creatine clearance less than 10 ml/min), in individuals without any renal disease, presenting either gastric ulceration or not, as well as in healthy subjects. Regardless of the group of patients, compared to normal mucosa a significant decrease in PGE2-like immunoactivity (about 50-70%) was found in mucosa from atrophic gastritis but not from superficial gastritis. Whenever patients of the control group or patients with kidney disease suffered from ulcers, PGE2-like immunoactivity showed a decrease of about 60-70% in the non-ulcerated mucosa compared to that of non-ulcer subjects. Moreover, ulcer patients showed the same frequency of gastritis and similar mucosal PGE2-like immunoactivity in their non-ulcerated mucosa. Furthermore, compared to the tissue from the ulcer edge, independent of the presence of renal disease, a relative deficiency of PGE2-like immunoactivity of about 50-60% was detected in the non-ulcerated mucosa of ulcer patients. We therefore conclude that chronic renal failure probably has no impact on PGE2 formation in the gastric mucosa. All told, relative mucosal PGE2 deficiency in gastric ulcer disease seems not to be correlated with chronic renal failure.
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PMID:Gastric mucosal prostaglandin E2 levels in gastric non-ulcer and ulcer patients with chronic renal failure or without renal disease, and in healthy subjects. 207 10

A follow up study with biopsy was initiated in 1982 to define the relations between variants of intestinal metaplasia and the evolution of chronic atrophic gastritis and gastric ulcer. All patients (58 with chronic atrophic gastritis and 66 with gastric ulcer) had intestinal metaplasia at the start of the study. In the six year period to 1988 a total of 241 biopsies were performed on the patients with chronic atrophic gastritis and 243 on the patients with gastric ulcer. Initially, 81% of the patients with chronic atrophic gastritis presented with type I intestinal metaplasia and 14% with type III intestinal metaplasia. During follow up type I was predominant, often associated with grades 2 and 3 active disease (81%) and 45% of these patients reverted to a non-intestinal metaplasia status by the third year of follow up. In contrast, type III metaplasia was more common in the absence of appreciable inflammation (78% of biopsy specimens), being persistent in five of seven patients in the third year of follow up, and was found to be associated with dysplasia in three of these patients. Similarly, the initial biopsy specimen showed type I metaplasia in most patients with gastric ulcer (82%) and type III in only 4%. Type I metaplasia was also predominant in these patients (80%), particularly in active disease (68%), gradually regressing with healing. In contrast, type III was associated with delayed ulcer healing and reactivation (75%; six of eight patients). We conclude that (a) type I is a short term reactive process which regresses with healing; (b) type III is related to prolonged injury and chronicity and may regress or progress to dysplasia; (c) persistent and more immature forms of metaplasia may carry an increased risk of malignancy.
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PMID:Variants of intestinal metaplasia in the evolution of chronic atrophic gastritis and gastric ulcer. A follow up study. 208 54

Immunohistochemical staining was performed by the ABC method using antibody against S100 protein for the identification of dendritic cells (DC) in the gastric mucosa, including gastric ulcer (n = 19), chronic atrophic gastritis (n = 28), gastric carcinoma (n = 65), fetal gastric mucosa (n = 11) and normal controls (n = 15). Lower numbers of DC may indicate an antigen-deficient state in normal and fetal gastric mucosa, while the diverse densities of DC in pathological conditions may reflect the differences in antigenic quantities and qualities and in individual immune responses. The close association between DC and lymphocytes in situ suggest an antigen-presenting capacity of DC controlling the activation of lymphocytes.
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PMID:[Immunohistochemical characterization of S100 proteinpositive dendritic cells in gastric mucosa]. 215 93

Quantitative analysis of dendritic cells (DC's) was carried out in tissue specimens of normal gastric mucosa (n = 15), gastric ulcer (n = 19), chronic atrophic gastritis (n = 28), and gastric carcinoma (n = 65) by ABC immunostaining with S100 protein antibody. Significant increases in DC number were observed in chronic atrophic gastritis with type III intestinal metaplasia and/or grade II, III dysplasia. The result suggests that DC's are potentially capable of presenting neoantigens associated with malignant transformation at the precancerous stage when malignant morphological changes have not yet taken place. Combined with routine diagnostic methods, the serial monitoring of DC density in gastric mucosa may be useful in the follow-up of premalignant lesions in the stomach and the diagnosis of early gastric carcinoma.
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PMID:S100 protein-positive dendritic cells and the significance of their density in gastric precancerous lesions. 224 39

A series of 417 endoscopic brush cytology-multiple biopsy specimens from 220 patients with clinically suspected gastritis was studied, with a 6-year follow-up, to find out whether brush cytology and histology combined provided better results than histology alone, in the endoscopic diagnosis of benign gastric ulcer. Each technique yielded the best results in its own field of observation. Cytology was superior to histology in diagnosing inflammatory reactions related to infection. In this series, 35.73% of the inflammatory smears were related to bacteria, 12.23% to fungi, 0.23% to herpes virus, and 0.23% to Giardia lamblia. Cytology also revealed active chronic superficial gastritis (33.57%) in these patients more often than histology (12.23%). Histology, primarily a technique for studying the architecture of the epithelium, found atrophic gastritis in 75.53% of the specimens examined, whereas cytology only identified 48.20%. As these findings show, even though histology is the diagnostic method of choice, whenever circumstances allow, the use of cytology as an adjunct is advantageous and will improve accuracy in the diagnosis of benign gastric ulcer, especially in the presence of inflammation or infection.
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PMID:Brush cytology in the endoscopic diagnosis of benign gastric ulcers. A useful adjunct to biopsy? 236 93

Most studies of gastric transmucosal potential difference concern acute damage. We studied this phenomenon in 168 patients with different pathologic processes: erosive gastritis, duodenal and prepyloric ulcer, atrophic gastritis, gastric ulcer and normal controls. Ag-AgCl electrodes and Agar-KCl bridges were used to record potential differences. Biopsies were taken from gastric antrum and body and potential differences were related to endoscopic and histologic findings. Maximal values of -29.2 + 2 and -22.2 + 1.6 for body and antrum, respectively, were found in normals. Lowest values (-19.4 + 1.4 and -14.3 + 1.5, respectively) were found in gastric ulcer, with intermediate values for the other conditions. Normal histologic findings were associated to potentials of -31 + 2 and -20 + 3.1 whereas lower values were recorded in patients with moderate or severe atrophic changes. Our findings suggest a relation between mucosal atrophy and lower transmucosal potential differences.
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PMID:[Potential difference of the gastric mucosa in gastroduodenal disease. Relation with endoscopical and histologic findings]. 251 90

Total 39 cases of carcinoma stomach were noticed out of 142 malignant tumours of GIT (27.46 percent). Histologically maximum cases were of diffuse type (56.41 percent) followed by intestinal type (35.89 percent) and indolent mucoid carcinoma (7.69 percent) of the stomach. The surrounding epithelium showed lot of changes in the intestinal type of carcinoma stomach. About 78.57 percent showed intestinal metaplasia, 14.28 percent of these cases showed chronic gastric ulcer and severe dysplasia (carcinoma in situ) and another 14.28 percent revealed villous adenoma with carcinoma in situ. In contrast to this, in diffuse variety, only 13.63 percent cases revealed intestinal metaplasia, 27.27 percent showed basal cell hyperplasia, stratification of the epithelium of crypts and diffuse infiltration of mucosa by malignant cells and 4.54 percent showed atrophic gastritis also. In mucoid carcinoma all cases had basal cell hyperplasia and stratification of crypts. Hence these conditions should be taken as premalignant lesions of stomach and should be cured in proper time.
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PMID:Pre-cancerous lesions of stomach. 255 96


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