Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper dealt with all patients who had visited their doctor in the gastroenterohepatologic (GEH) out-patient service in 1988. A total of 1716 and 2566 clinically subspecialistic gastroenterohepatologic and endoscopic surveys were made, respectively. Upper endoscopy was performed in 783 and lower endoscopy in 1783 patients. This paper was aimed at establishing the morbidity structure on one-year material from the patients visiting subspecialistic GEH service, whereby sex, age and frequency according to the kind of disease were taken into account. The most frequent diseases were as follows: ulcer disease 49.11%, biliary tract diseases 19.28%, liver diseases 14.62% and pancreas diseases 8.50%, while other diseases accounted for the less percent. The greatest morbidity ranged in patients from their fourth to sixth decade of life. Ulcer, liver and pancreas diseases were more frequent in males, while biliary tract diseases were more frequently found in females. Upper endoscopy revealed duodenic ulcer in 26.18%, stomach ulcer in 17.88%, gastritis and duodenitis in 18.52%, stomach polyps in 2.04% and stomach carcinoma in 1.92%. The analysis of 742 rectosigmoidoscopic patients showed hemorhoidal disease in 43.53%, chronic nonspecific collitis in 9.43%, rectosigmoidoscopic polyps in 7.15%, carcinoma of the rectum in 3.37% and ulcerous collitis in 5.66%. The ratio of polyps and carcinoma of the rectum was 2:1. In the out-patient GEH service apart from the basic health activity, health-educational, research and educative activities were performed. In the further development of this service, its scope of work, diagnostic and therapeutic procedures would be extended in dependence on economic power of society regarding the supply of equipment and manpower.
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PMID:[Present possibilities and perspectives in the work of the gastroenterohepatology service in a polyclinic]. 263 35

Effects of zinc in gastric ulcer have been reviewed through investigations carried out on zinc acexamate (ZAC). ZAC is an organic compound that has been shown to possess an experimental antiulcer effect and a wide therapeutic index, making it a useful drug in the treatment of peptic ulcer disease. ZAC protects from ulceration in several experimental models such as pylorus occlusion, reserpine-induced ulcer, necrotizing agents, PAF-induced ulcer and cold-restraint stress. ZAC first reduces the gastric acid output by inhibiting the mast cell degranulation, an action likely to be mediated through a membrane stabilizing action. Secondly, it enhances the mucosal protection factors by increasing mucus secretion, inhibiting the H+ retrodiffusion and improving microcirculation. ZAC is also effective in acetic acid-induced chronic ulcer, restoring the continuity of the damaged mucosa. Several clinical trials have shown the usefulness of ZAC in acute and maintenance treatment of both gastric and duodenal ulcers. Endoscopic studies showed that ZAC reduced the inflammatory processes (gastritis and duodenitis) associated with ulcer healing. This reduction was statistically significant and not observed with other comparative treatments (H2-antagonists). The observed side-effects were minimal and affected less than 2% of treated patients. The pharmacological profile, clinical effectiveness and good tolerance of ZAC suggest this compound as an interesting option in the treatment of peptic disease.
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PMID:Zinc compounds, a new treatment in peptic ulcer. 266 Nov 83

From August 1987 through July 1988, we evaluated antral biopsy specimens for Campylobacter pylori (CP) in 212 patients undergoing upper endoscopy. For those patients who had multiple endoscopies, the first endoscopy in which a urease test, histology, and culture were done was used to determine CP status. A patient was regarded as CP-positive if the culture was positive or if both a urease test and the histology were positive. Blacks had an increased CP positivity (61.2%) compared to whites (31.5%). Among non-ulcer patients, CP positivity was 52% in black patients and 18% in white patients. Age and gender were unrelated to CP positivity among controls and those without ulcers. There was increased CP positivity in patients with duodenal ulcers (85%), compared with those without ulcers (37%), and a trend toward increased positivity in those with gastric ulcer (53%) and duodenitis (50%). There was no increased CP positivity in patients with gastroesophageal reflux disease (28%), gastritis (29%), non-ulcer dyspepsia (43%), or the control patients with no gastroduodenal mucosal abnormalities (40%). CP-negative DU patients were older (average 71 yr) than CP-positive DU patients (43 yr), and female DU patients had a lower CP positivity (71%) than males (94%).
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PMID:Prevalence of Campylobacter pylori in patients undergoing upper endoscopy. 272 34

355 patients suffering from dyspepsia with an endoscopic pathological picture were examined. Campylobacter pylori was sought histologically and by culture. Histological and cultural results were compared. There were no bacteria on the gastric mucosa of 46 patients who had no histopathological evidence of lesions. Cultural studies were performed in 40 cases on endoscopic instruments used during the examination, before and after standard sterilization. Campylobacter pylori was found on the gastric mucosa of 224 patients (63.09%); 91.93% with duodenal ulcer; 71.87% with gastric ulcer; 54.23% with erosive duodenitis; 56.71% with erosive gastritis and 54.81% with chronic gastropathy. The agreement between the two techniques was 75.39%, with a male prevalence (p = 0.05). Campylobacter pylori was present on the gastric mucosa of 10.86% of patients without histopathological evidence of lesions. Standard sterilization with alkyl-dimethyl-benzyl ammonium eliminated the campylobacter in 100% of cases.
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PMID:[Campylobacter pylori colonization and gastroduodenal pathology]. 320 Apr 72

During gastroduodenoscopic examination of 225 patients, bioptic mucosal specimens were taken for bacteriological and histological examination (Table 1). Campylobacter (C.) pylori was isolated from 7 out of 9 patients (78%) with gastric ulcer, from 59 out of 60 (98%) with duodenal ulcer, from 24 out of 31 (77%) with gastric erosions, from 10 out of 10 (100%) with duodenitis, from 14 out of 16 (88%) with chronic active gastritis, from 40 out of 73 (55%) with chronic inactive gastritis and from none out of 26 patients (0%) with normal mucosa (Table 2). To study the immune response an ELISA was developed which proved to give well reproducible and specific test results (Fig. 1). IgA- and IgG-titres were strongly reduced after absorption with C. pylori, but not with other antigens (including C. jejuni and C. coli, Table 3). Some sera gave reactions at higher titres when tested with the patient's own strain than with the standard antigen which is a mixture of 4 strains (Table 4). This indicates differences of the antigen composition within the species C. pylori. Sera from patients with positive culture showed higher IgG- and IgA-titres than sera from patients without isolation of C. pylori. The IgM-titres, however, were comparable in both groups (Fig. 3). Partially, sera from patients without C. pylori also showed high IgG-titres which were positively correlated with the patient's age. About 60% of culturally positive patients had specific IgA in their gastric juice, whereas this was not so with patients without isolation of C. pylori (Fig. 6). Examination of sera from healthy children and blood donors revealed that IgG but not IgA or IgM rose significantly with increasing age (Figs. 7-9). As can be concluded from the results of cultural and serological tests, C. pylori seems to be responsible at least for a part of cases of gastritis and peptic ulcer.
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PMID:Frequency of occurrence of Campylobacter pylori and analysis of the systemic and local immune response. 343 87

The effect of nonsteroidal antiinflammatory drugs (NSAIDs) on duodenal mucosa was assessed both retrospectively and prospectively. In 444 patients with duodenal ulcer, the incidence of upper gastrointestinal bleeding was five times higher in 56 patients who were treated with NSAIDs than in those who did not receive NSAIDs. Indomethacin and naproxen had the most potent damaging effects. In a control group of patients with gastric ulcer, nine out of 134 had taken NSAIDs. The incidence of bleeding in these patients was three times higher than in those who were not on NSAIDs. The effect of indomethacin, 150 mg/day, on the upper gastrointestinal tract was examined in a prospective study of 75 patients with acute musculoskeletal disorders. Endoscopy after 1 week of therapy showed that 45% had mucosal damage in the duodenum, and this was as frequent and as severe as the gastric mucosal damage. In most instances, the duodenal damage was erosive duodenitis.
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PMID:Duodenal mucosal injury with nonsteroidal antiinflammatory drugs. 349 47

Campylobacter pyloridis is a newly discovered bacterium which has been implicated in gastric pathology. C. pyloridis was looked for by hematoxylin and eosin staining and culture (chocolate and brucella blood agar) in gastric antral biopsies in 136 unselected patients suffering from epigastric pain. The distribution of C. pyloridis positive cases according to the endoscopic diagnosis was as follows: duodenal ulcer (19 positive/21 tested), duodenitis (6/10), gastric ulcer (9/21), gastritis (13/26), and normal endoscopy (21/58). The association was statistically significant for duodenal ulcers (p less than 0.001). All of the 68 C. pyloridis positive patients showed histologic signs of gastritis as compared to 29 of the 68 C. pyloridis negative patients. The two techniques detection were comparable in sensitivity: 57 were detected by culture only and 63 by microscopy only. We also looked for C. pyloridis in biopsies of the body of the stomach in 71 patients. Bacteria were found in 33 of 36 cases with C. pyloridis positive antral biopsies (15 had histologic lesions) but only in 2 of 35 C. pyloridis antrum negative cases. Therefore, C. pyloridis was tightly associated with histologic signs of antral gastritis and with duodenal ulcers when diagnosed by endoscopy.
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PMID:"Campylobacter pyloridis" and epigastric pain: endoscopic, histological, and bacteriological correlations. 358 69

Diagnostic, clinical and therapeutic studies were carried out, under clinical conditions, on 80 patients with endoscopically confirmed chronic erosive gastritis and gastroduodenitis. The subjects aged between 20 and 59 are most often affected, the males being 2 times more often affected. The histological study on the purposeful biopsy of the mucosa of the stomach and duodenum established, most frequently, the presence of chronic superficial gastritis and duodenitis, followed by initial chronic atrophic gastritis. The clinical symptoms were studied in details--pain (91.20%), dyspeptic syndrome (83.7%), hemorrhagic manifestations (hematemesis or melena)--23.7%. In 40% of the patients with erosive gastritis and gastroduodenitis, the disease was combined with duodenal ulcer and in 7.5%--with gastric ulcer. The etiological factors of importance are: food factors, dietetic errors, alcoholic consumption, drug effects (first of all derivatives of Rauwolfia serpentina, followed by the peroral broad spectrum antibiotics, etc), duodenogastric reflux and toxic effect of the bile acids on the antral mucosa. The endoscopic studies are of decisive importance for the diagnosis and determining the effect of the treatment. The treatment with a dietetic regimen, gastro-protective drugs (almagel, preparations of deglycyrrhized licorice--alcid V, vitamin A, spasmolytics) eliminated the erosive alterations in 75% of the patients after 3-week treatment.
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PMID:[Erosive gastritis and gastroduodenitis--clinical, diagnostic and therapeutic studies]. 361 7

The coincidence of gastric diseases and chronic duodenitis has been investigated on biopsies and preparations of stomach and duodenum by a quantitative histologic method. The histologic classification of duodenitis was made according to Whitehead et al. 9 of 40 patients with a chronic atrophic gastritis had a duodenitis grade 1. 10 of 40 patients with a chronic gastric ulcer had a duodenitis grade 1 and one patient grade 2. 14 of 40 patients with a gastric cancer had a duodenitis grade 1. By statistical investigations it has been found out that patients with an ulcer or cancer do not have duodenitis more often than patients with gastritis. A possible duodenitis concerning the investigated gastric diseases is mainly due to the chronic gastritis that also could be proved by all patients suffering from ulcer or cancer.
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PMID:[Duodenitis in stomach diseases--a quantitative histologic study]. 362 60

In the course of routine gastroduodenoscopic examination of 218 patients bioptic mucosal specimens were examined bacteriologically for the presence of Campylobacter (C.) pylori. The organism was isolated from 52 out of 53 patients (98%) with duodenal ulcer, 7 out of 9 with gastric ulcer (78%), 24 out of 31 with mucosal erosions (77%), 10 out of 10 with duodenitis (100%), 16 out of 16 with chronic active gastritis (100%) and from 40 out of 73 patients (55%) with inactive chronic gastritis. By contrast, all specimens from 26 patients with endoscopically and histologically normal mucosa were negative for this bacterium. The rate of elimination of C. pylori from mucosal specimens was investigated as a first step towards studying the influence of antibiotic therapy upon healing of gastric and duodenal ulcers. For this purpose 30 patients with duodenal ulcers were treated either with ranitidine alone (15) or together with bacampicillin (15), which was shown to be highly active in studies with ampicillin in vitro. After 4 weeks the organism was still found in specimens from all patients treated with ranitidine alone, but also in 12 out of 15 patients given combined therapy. This result demonstrates that systemic antimicrobial chemotherapy with bacampicillin is insufficient to eradicate C. pylori from the stomach and the duodenum.
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PMID:[Campylobacter pylori, gastritis and peptic ulcer]. 363 Jan 80


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