Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 3-pit coal mines, all workers were examined by means of an inquiry. Apart from personal data the inquiry included information on the category of work performed, length of employment, family state and socio-living conditions as well as diseases of digestive tract. The diagnosis of peptic ulcer and data on its course were based on medical documentation of Plant Outpatient Departments. Collected material comprised 9361 persons, i.e. 95% of the whole population examined. After having excluded women, employed only on surface, results were worked out concerning the population of 8302 men employed both underground and on surface. In this mining population one found 7.92% persons suffering from peptic ulcer; thus the occurrence of the disease resembled that of general population. The rate of duodenal and gastric ulcer was identical. The studies indicated that the percentage of peptic ulcer was increased proportionally to age and number of children and was greater in married than in bachelors. No greater percentage was found in widowers and divorcees, or in those eating in canteens, partaking cold meals during work or drinking alcohol. Instead in smokers a greater percentage of peptic ulcer was found. The rate of the occurrence of peptic ulcer is greater with higher salaries, additional paid, or social, work, and in case of daily travelling on a motorcycle or bicycle. Finally it was indicated that those suffering from peptic ulcer limited smoking and drinking habits and endeavoured to be fed properly.
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PMID:[Epidemiological examinations for peptic ulcer in miners of pit-coal mines. I. Effect of socioeconomic factors]. 60 82

Rats were orally administered ascorbic acid at a dose of 30 g/liter during either total starvation, partial starvation, the activity-stress ulcer procedure, or the restraint-cold procedure. In four experiments, ascorbic acid failed to exert significant protective action against stomach ulcer formation and, in fact, may have potentiated the ulcerogenic process.
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PMID:Ascorbic acid and stress ulcer in the rat. 72 47

With an oscillograph according to Gesenius and Keller, the authors investigated the oscillographic waves in lower limbs and their reductions after exposition to cold and exercise in 27 men and 22 women with gastric or duodenal ulcer as well as in 18 healthy men and 12 healthy women. Both groups were subdivided into age categories from 19 to 30 and from 45 to 54 years. It was found that 1) peripheral arteries in men in the lower age category with duodenal ulcer reacted to cold stimulus by a more marked vasoconstriction than the arteries in healthy men in the same age category; 2) in women with duodenal ulcer the same observation was made in not only the younger, but also in the higher age category; 3) peripheral vasoconstriction after application of cold in women with duodenal ulcer, aged up to 30 years and 45-54 years was higher than in women with gastric ulcer in the corresponding age categories; 4) peripheral arteries of the younger men as well as of the younger and older women with duodenal ulcer reacted often more strongly to exercise and to exercise following application of cold in comparison with corresponding controls, and in the case of the women, in addition, with those with gastric ulcer.
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PMID:Peripheral arterial reactivity in patients with peptic ulcers and in healthy subjects. 72 86

Gastric ulcer development and changes in the contents of glucose, free fatty acids (FFA), and K and Ca ions in the blood were studied in rats subjected to a graded stress of immobilisation and cold. During stress the volume of secretion and the output of HCl, decreased although the concentration rose slightly. Chlorpromazine (CPZ), thioridazine (TRZ), spiroperidol (SPI), and fluphenazine (FLU) inhibited to various degrees ulcer formation during stress. SPI reduced stress-induced mucosal damages in 94%, but FLU even in doses 100 times smaller than those of the other drugs counteracted ulcer formation. CPZ, TRZ and SPI in preventive doses increased proportionally the blood glucose level both in control rats and in those subject to stress. FLU in effective doses produced no hyperglycemia either in control rats or in those exposed to stress. We conclude that the prevention of gastric ulcer development by neuroleptics may be the result of their antisecretory action and counteracting of breakdown of sympathetic activity during severe stress.
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PMID:The effect of neuroleptics on the development of gastric ulcers in rats exposed to restraint-cold stress. 126 58

1. Rats were prepared with intracerebral cannulas for microinjection of test compounds into various brain regions. 2. Selective dopamine D1 agonists (SKF38393, SKF75670C) and a D1 antagonist (SCH23390) were injected into the cell body regions of the nigrostriatal, mesolimbic and mesocortical dopamine tracts or into a terminal field of these tracts (caudate nucleus, central nucleus of the amygdala and medial prefrontal cortex) prior to gastric ulcer induction by cold-restraint stress or duodenal ulcer induction by cysteamine. 3. The dopamine D1 agonists reduced both stress gastric ulcers and duodenal lesions most significantly when given into either the cell body region or a terminal field of the mesolimbic DA tract with much less effects seen for the nigrostriatal tract. 4. No effects were seen upon infusion of the agonists into the mesocortical cell body or terminal field regions. 5. The D1 antagonist worsened both stress-induced gastric lesions and duodenal lesions if given into mesolimbic regions and, to a much lesser extent when injected into the nigrostriatal tract. 6. No effect of the D1 antagonist was seen upon administration into the mesocortical tract. 7. Central dopamine D1 receptors, particularly in the mesolimbic DA tract, appear to be involved in mediating the gastrointestinal consequences of exposure to stress.
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PMID:Central dopamine involvement in experimental gastrointestinal injury. 134 59

A slow-release zinc complex, zinc monoglycerolate (ZMG) was examined for its potential gastroprotective activity in various gastric ulcer models. These models comprised (a) oral or parenteral non-steroidal anti-inflammatory drugs (NSAIDs) given to rats whose gastrointestinal mucosa was pre-sensitized by prior development of arthritis, oleyl alcohol-induced inflammation and cold exposure, (b) oral ethanol (12.5-100%) with and without added 4% HCl, (c) intraperitoneal reserpine (5 mg kg-1) in arthritic and normal rats and in normal mice, (d) oral NSAIDs given to mice in which acid and pepsin production was stimulated by co-administration of intraperitoneal bethanechol chloride (5 mg kg-1) to enhance ulcer development, and (e) NSAIDs given to carrageenan-inflamed rats to determine effects of ZMG on paw inflammation. In these models, ZMG given orally was effective in preventing development of gastric lesions, except with propionic acid NSAIDs; the effective doses being apparently dependent on the severity of the mucosal injury. In many of the models ZMG was superior to zinc sulphate and other zinc salts or metal ion complexes investigated but was slightly more effective or equipotent compared with zinc acexamate. ZMG did not impair the anti-oedemic effects of NSAIDs. ZMG is thus an effective agent in preventing ulcer development in a wide range of model systems and may be more effective than zinc salts because of the controlled slow-release of zinc from the complex.
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PMID:Anti-ulcer activity of a slow-release zinc complex, zinc monoglycerolate (Glyzinc). 135 71

Beta-sitosterol-beta-D-glucoside and its aglycone (the major constituent of the seed oil of Hippophae rhamnoides L.) were investigated for their antigastroulcerative activity in rats. Two experimental gastric ulcer models were selected: chronic acetic acid-induced ulcers and cold stress-induced ulcers. Both the glucoside and its aglycone showed antiulcerative activity in chronic acetic acid-induced gastric ulcer models, and their effects were at least comparable to the effects of wishupin in combination with cimetidine. The effect of aglycone appears better than the glucoside's. Glucoside also showed visibly antiulcerative effects on cold stress-induced ulcers, but wishupin combined with cimetidine did not have such effects.
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PMID:[The antigastroulcerative activity of beta-sitosterol-beta-D-glucoside and its aglycone in rats]. 139 37

We have reviewed all endoscopies performed in our hospital between 1977 and 1986. During that period, 1337 endoscopies were performed to identify bleeding from peptic ulcers. Excluded were cases in which a predisposing factor was found, such as the use of ulcerogenic drugs. Also excluded were chronic or critically ill patients. The remaining 540 cases were reviewed. In 447 of those cases, the bleeding lesion was a duodenal ulcer, whereas, in 93 cases, a gastric ulcer was found (a ratio of 5:1). The seasonal variation in the incidence of bleeding from peptic ulcers was evaluated. We found a significant difference in bleeding in the cold and hot seasons, the incidence being significantly greater during the cold season (November until February). A similar pattern was found for bleeding from both duodenal and gastric ulcers.
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PMID:Seasonal pattern in the incidence of bleeding caused by peptic ulcer in Israel. 159 Mar 10

Bilateral microinjections of dopamine (DA, 0.3, 3.0 or 30.0 micrograms) or the DA-agonist, bromocriptine (3.0 micrograms) into the basolateral amygdala (BLA) dose-dependently attenuated cold restraint stress (3 h at 4 degrees C)-induced gastric ulcer formation in rats. On the other hand, intra-BLA injections of the neurotoxin, 6-hydroxydopamine (10 micrograms) of the DA-antagonist, haloperidol (0.1 or 1.0 micrograms) aggravated such stress ulcer formation. All these effects were seen only when the injection sites were localized in the posterior (and not the anterior) BLA. Further, pretreatment of rats with haloperidol (0.1 micrograms) clearly antagonized the gastric cytoprotective effects of DA or bromocriptine (both at 3.0 micrograms), when both chemicals were injected in the posterior BLA. The results indicate that DA-ergic mechanisms in the posterior BLA are important for the regulation of gastric mucosal integrity during cold restraint stress.
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PMID:The basolateral amygdala, dopamine and gastric stress ulcer formation in rats. 168 35

The involvement of histaminergic mechanisms in the regulation of some stress responses was studied in rats. The brain neuronal histamine (HA) depletor, alpha-fluoromethyl histidine (alpha-FMH), at doses (50 or 100 mg/kg) which markedly lower brain HA, significantly attenuated the gastric ulcer formation and the elevation in plasma corticosterone in response to cold restraint stress (CRS). alpha-FMH also appreciably reduced gastric mucosal HA content. The H1-antagonist, pheniramine (25 mg/kg), attenuated both the gastric mucosal and endocrine response to CRS, while the effects of the H2-antagonist, cimetidine (200 mg/kg), were on the plasma corticosterone levels. These results are discussed in light of complex HA-ergic mechanisms in the maintenance of physiological homeostasis during stress.
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PMID:Role of histaminergic mechanisms in the regulation of some stress responses in rats. 176 2


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