Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To clarify the histogenesis of squamous cell carcinoma of esophagus, 307 esophagus resected from autopsied cases have been thoroughly examined. These specimens were dyed with Lugol solution and entirely blocked to study subserial sections. Among these specimens, two subclinically superficial squamous cell carcinomas were found. First case uncovered was that of a woman who had died of a carcinoma of uterus. Microscopic examination revealed a small carcinoma in situ, located in the cervical portion of the esophagus, though this lesion showed no associated dysplasia. The other case was that of an old man who had died of a massive hemorrhage from a gastric ulcer, associated with carcinomas of the lip, liver, and prostate. The esophageal lesion was an intramucosal carcinoma located in the mid esophagus that was encountered with moderate dysplasia. These examples are not only quite rare as being multiple primary carcinomas but they also suggest two possible types of cancer development of the esophagus: one that progresses from normal mucosa, and the other from dysplastic mucosa.
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PMID:[Two autopsy cases associated with a latent superficial carcinoma of esophagus]. 254 39

Total 39 cases of carcinoma stomach were noticed out of 142 malignant tumours of GIT (27.46 percent). Histologically maximum cases were of diffuse type (56.41 percent) followed by intestinal type (35.89 percent) and indolent mucoid carcinoma (7.69 percent) of the stomach. The surrounding epithelium showed lot of changes in the intestinal type of carcinoma stomach. About 78.57 percent showed intestinal metaplasia, 14.28 percent of these cases showed chronic gastric ulcer and severe dysplasia (carcinoma in situ) and another 14.28 percent revealed villous adenoma with carcinoma in situ. In contrast to this, in diffuse variety, only 13.63 percent cases revealed intestinal metaplasia, 27.27 percent showed basal cell hyperplasia, stratification of the epithelium of crypts and diffuse infiltration of mucosa by malignant cells and 4.54 percent showed atrophic gastritis also. In mucoid carcinoma all cases had basal cell hyperplasia and stratification of crypts. Hence these conditions should be taken as premalignant lesions of stomach and should be cured in proper time.
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PMID:Pre-cancerous lesions of stomach. 255 96

As for precancerous lesion of the stomach detail analysis of endoscopic follow-up cases and histopathological investigations brought some new informations on its carcinogenesis. In this paper recent several reports were introduced and discussed on new opinion of precancerous conditions such as adenoma, intestinal metaplasia, gastric ulcer, remnant stomach and H. pylori. Gastric adenoma was considered to be neoplastic because of high incidence of carcinoma in situ. The stomach coexisted with adenoma showed high percentage of new arising tumor in same stomach and therefore, we can say that these are thought to be high risk group for well differentiated adenocarcinoma. Concerning the relation between intestinal metaplasia and gastric cancer we have never obtained final conclusion. However, it is likely that incomplete type of intestinal metaplasia appeared to be coexistent with gastric cancer, especially intestinal type carcinoma, which was thought to be paracancerous lesions. Recent advance of molecular biology has indicated new knowledge on gastric carcinogenesis, suggestive of multistep pathways. According to their reports, genomic instanbility appeared frequently in gastric adenoma and intestinal metaplasia as well as gastric carcinoma. Gastric carcinogenesis for ulcer, remnant stomach and H. pylori was also discussed. In near future the mechanism of gastric carcinogenesis is expected to be solved from view point of genetic events.
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PMID:[New concepts on precancerous lesions of the stomach]. 860 11