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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the study of a group of 178 unselected patients (105 men, 73 women, mean age 44.5 years), from a population at high risk for gastric carcinoma, who presented with chronic dyspepsia, a minimum of 8 gastric and oesophageal biopsy specimens were taken during upper gastro-intestinal endoscopy, and examined histologically and histochemically for the presence of Campylobacter pylori and other pathological lesions. Gastric colonisation by C. pylori was found in 75% of men and 68.4% of women. In 90% of patients with duodenal or gastric ulcer and in 71.6% of patients with non-ulcer and non-cancer dyspepsia there was a moderate or severe degree of bacterial colonisation. Association between C. pylori colonisation and microscopic evidence of type B gastritis, gastric or duodenal ulcer, gastric cancer, oesophagitis and oesophageal glycogenic acanthosis was found.
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PMID:The association of Campylobacter pylori with mucosal pathological changes in a population at risk for gastric cancer. 247 Jan 57

Nineteen patients with colorectal adenocarcinoma, three with cholangiocarcinoma, two with hepatocellular carcinoma, and one with carcinoid were treated with hepatic artery infusion chemotherapy. An implantable pump system was used to deliver floxuridine (FUdR), starting at 400 mg for 2 weeks with 2 weeks of rest. Eleven of 15 (73%) measurable patients with colorectal carcinoma responded. Of 6 complete responses, 4 were documented by laparotomy, including 1 with cholangiocarcinoma. Toxicity included dyspepsia and elevated liver function tests in all patients, gastric ulcer in 2, cholecystitis in 2, and sclerosing cholangitis in 3. Overall median survival for the colon cancer patients has not been reached at 16 months. Regional disease was controlled in the majority of patients treated with this regimen with acceptable toxicity and good quality of life.
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PMID:Hepatic perfusion with FUdR utilizing an implantable system in patients with liver primary cancer or metastatic cancer confined to the liver. 254 47

To clarify the histogenesis of squamous cell carcinoma of esophagus, 307 esophagus resected from autopsied cases have been thoroughly examined. These specimens were dyed with Lugol solution and entirely blocked to study subserial sections. Among these specimens, two subclinically superficial squamous cell carcinomas were found. First case uncovered was that of a woman who had died of a carcinoma of uterus. Microscopic examination revealed a small carcinoma in situ, located in the cervical portion of the esophagus, though this lesion showed no associated dysplasia. The other case was that of an old man who had died of a massive hemorrhage from a gastric ulcer, associated with carcinomas of the lip, liver, and prostate. The esophageal lesion was an intramucosal carcinoma located in the mid esophagus that was encountered with moderate dysplasia. These examples are not only quite rare as being multiple primary carcinomas but they also suggest two possible types of cancer development of the esophagus: one that progresses from normal mucosa, and the other from dysplastic mucosa.
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PMID:[Two autopsy cases associated with a latent superficial carcinoma of esophagus]. 254 39

Total 39 cases of carcinoma stomach were noticed out of 142 malignant tumours of GIT (27.46 percent). Histologically maximum cases were of diffuse type (56.41 percent) followed by intestinal type (35.89 percent) and indolent mucoid carcinoma (7.69 percent) of the stomach. The surrounding epithelium showed lot of changes in the intestinal type of carcinoma stomach. About 78.57 percent showed intestinal metaplasia, 14.28 percent of these cases showed chronic gastric ulcer and severe dysplasia (carcinoma in situ) and another 14.28 percent revealed villous adenoma with carcinoma in situ. In contrast to this, in diffuse variety, only 13.63 percent cases revealed intestinal metaplasia, 27.27 percent showed basal cell hyperplasia, stratification of the epithelium of crypts and diffuse infiltration of mucosa by malignant cells and 4.54 percent showed atrophic gastritis also. In mucoid carcinoma all cases had basal cell hyperplasia and stratification of crypts. Hence these conditions should be taken as premalignant lesions of stomach and should be cured in proper time.
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PMID:Pre-cancerous lesions of stomach. 255 96

A case of stomach carcinoma was examined in a 45-year-old male by using histochemical and electron microscopic techniques. The carcinoma had arisen from chronic gastric ulcer accompanied with fundic gland hyperplasia and located in the body of the stomach. Histologically, it was a nondifferentiated scirrhous carcinoma involving signet ring and minor polymorphic cells with eosinophilic cytoplasm. Electron microscopically, the tumors had cells containing a large body of mucoidal granules, great quantities of cells having various endocrine granules, and cells showing mixed endocrine-exocrine secretion. It was suggested that there might be a pathogenetic relationship of fundal cell hyperplasia and signet ring cell carcinoma development, on the one hand, and the existence of tumor endocrine cells, on the other.
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PMID:[Stomach cancer with tumor endocrine cells in the presence of chronic ulcer]. 257 May 63

This paper dealt with all patients who had visited their doctor in the gastroenterohepatologic (GEH) out-patient service in 1988. A total of 1716 and 2566 clinically subspecialistic gastroenterohepatologic and endoscopic surveys were made, respectively. Upper endoscopy was performed in 783 and lower endoscopy in 1783 patients. This paper was aimed at establishing the morbidity structure on one-year material from the patients visiting subspecialistic GEH service, whereby sex, age and frequency according to the kind of disease were taken into account. The most frequent diseases were as follows: ulcer disease 49.11%, biliary tract diseases 19.28%, liver diseases 14.62% and pancreas diseases 8.50%, while other diseases accounted for the less percent. The greatest morbidity ranged in patients from their fourth to sixth decade of life. Ulcer, liver and pancreas diseases were more frequent in males, while biliary tract diseases were more frequently found in females. Upper endoscopy revealed duodenic ulcer in 26.18%, stomach ulcer in 17.88%, gastritis and duodenitis in 18.52%, stomach polyps in 2.04% and stomach carcinoma in 1.92%. The analysis of 742 rectosigmoidoscopic patients showed hemorhoidal disease in 43.53%, chronic nonspecific collitis in 9.43%, rectosigmoidoscopic polyps in 7.15%, carcinoma of the rectum in 3.37% and ulcerous collitis in 5.66%. The ratio of polyps and carcinoma of the rectum was 2:1. In the out-patient GEH service apart from the basic health activity, health-educational, research and educative activities were performed. In the further development of this service, its scope of work, diagnostic and therapeutic procedures would be extended in dependence on economic power of society regarding the supply of equipment and manpower.
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PMID:[Present possibilities and perspectives in the work of the gastroenterohepatology service in a polyclinic]. 263 35

Detection of precancerous lesions and early phases of stomach carcinoma is the basic aim in the fight against this malignant tumour of a very bad prognosis. On the basis of data from contemporary literature, the basic elements of epidemiology and pathology of stomach precancerous lesions are presented in this paper. Chronic gastritis, intestinal metaplasias, dysplasias, chronic stomach ulcer and the state after the stomach resection due to benign disease are dealt with from that aspect. The terms of precancerous states are considered in the introductory part. Through the definition of specific morphological changes general practitioners could be given help in elucidating this problem more successfully.
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PMID:[Precancerous lesions in the gastrointestinal tract. I. The stomach]. 263 90

The diagnostic yield of the initial endoscopy performed in 8,043 consecutive patients over a 14-year period was analyzed according to age. The mean age of women (57.4 years; 50.9% 60 years or older) was higher than that of men (50.5 years; 29.8% 60 years or older). A younger age group with a mean male age of under 50 years comprising acid-related peptic diseases or normal findings was distinguishable from an intermediate group with a mean age of between 50 and 60 years. This included patients with gastric ulcer disease, who were an average of 8 years older than duodenal ulcer patients. The highest-age group comprised gastric and esophageal cancer patients with male mean ages of 64.6 and 64.7 years, respectively. In all diagnostic categories except esophageal carcinoma, the mean age of women exceeded that of men by 2.7-10.2 years. The histological grading of gastritis also correlated closely with age, women having higher mean ages than men, and all gastritis grades in the body were associated with a higher mean age than identical grades in the antrum. These data shed additional light on the age distribution of major upper GI tract diseases, and also on the peculiarities of upper GI endoscopy in advanced age.
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PMID:Diagnostic yield of upper gastrointestinal endoscopy in relation to age: retrospective analysis of 8,043 patients. 273 8

To study how the normal gastric mucosa develops chronic gastritis, gastric ulcer or cancer, biopsies from 103 patients with non-tumor gastric diseases and operative specimens from 12 patients with stomach carcinoma were examined for epithelial antigen (EA). In the peroxidase-antiperoxidase reaction performed on paraffin-embedded and cryostat sections of the gastric mucosa, monoclonal antibodies (MAb) to antigens located on the membranes of fatty breast milk globules were employed, which had been presented by the Department of Biomedical Sciences, Tampere University (Finland). The MAb 111C12-identified antigenic determinant was found to occur in 12.8% of the nonmalignant gastric mucosa examined and 48% of the stomach carcinoma one. The detection of EA is not characteristic of the given portion of the gastric mucosa in carcinoma.
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PMID:[Detection of the epithelial membrane antigen in patients with varying status of the gastric mucosa using monoclonal antibodies]. 277 94

Gastric biopsies in peptic ulcer are to be taken from various sites of the organ. This is due to the fact that the differential diagnosis between gastric ulcer and ulcerative carcinoma is the most important goal of biopsy. Therefore, at least 4-6 pieces should be dissected from the bottom and margins of ulcers as 1-2 pieces of the biopsy taken may show no elements of tumor tissue. Single biopsies may be not only useless, but hazardous to the patient while "pseudonegative" resolutions of a morphologist soothe the patient and his physician and delay the time of examination. Biopsy specimens give an insight into the stages of peptic ulcer, features of a reparative process and its abnormalities.
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PMID:[Importance of biopsy in stomach ulcer]. 280 45


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