Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038358 (gastric ulcer)
 5,179 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 54 year old man without pathologic past history but mild hypertension, obesity and gastric ulcer, presented with a syndrome of Wallenberg. He had complained for five days of progressive and diffuse headache. The neurological condition improved initially, but the patient died suddenly two weeks later. Pathological examination showed no significant alteration except for left ventricular enlargement and mild arteriosclerosis. There was a hemodissection (dissecting aneurysm) of the left vertebral artery next to the inferior oliva. It induced a lateral infarct and a limited dorsal infarct at the middle third level of medulla oblongata. Although the location of the arterial changes is usual, their nature is exceptional. The cause of the arterial hemodissection could not be ascertained: fibrous arterial dysplasia, atherosclerosis or congenital abnormalities of internal elastic layer may be discussed. But no definite conclusion can be reached.
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PMID:[Wallenberg's syndrome due to a dissecting aneurysm of the vertebral artery]. 713 26

Six patients with necrosis of the lesser curvature of the stomach after proximal selective vagotomy are described. The decreased circulation due to proximal selective vagotomy can lead to extensive necrosis of the lesser curvature in cases of lack of submucosal plexus, and especially in cases with stenotic arteriosclerotic collaterals. However, one must differentiate localized perforations caused by a intraoperative laceration of the gastric wall and perforations of a gastric ulcer. Renal insufficiency, hypertension, diabetes mellitus, generalized arteriosclerosis, and previous splenectomy are, in our experience, contraindications for a proximal selective vagotomy. Those cases should be treated by selective gastric vagotomy with pyloroplasty.
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PMID:[The pathogenesis of stomach wall necrosis following selective proximal vagotomy]. 723 76

We have previously reported that the decrease in gastric mucosal blood flow (GMBF) and consumption coagulopathy (CC) mainly contribute to the development of postoperative bleeding in the upper gastrointestinal (GI) tract in patients with abdominal aortic aneurysm (AAA). In the present study, we investigated whether our treatment for patients with low GMBF or CC effectively prevented postoperative gastric bleeding induced by gastric ulcer or acute gastric mucosal lesion. Preoperative endoscopic examinations in 66 patients with AAA and 60 patients with arteriosclerosis obliterance (ASO) revealed that 50.0% of AAA and 16.6% of ASO patients had accompanying gastric ulcer or multiple erosions. In 38 AAA and 36 ASO patients, GMBF was measured using a laser Doppler flowmeter through an endoscope. The GMBF was severely impaired in AAA patients and moderately impaired in ASO patients. The platelet counts and fibrinogen levels were significantly decreased in these 38 AAA patients compared with controls. Furthermore, fibrinogen degeneration product (FDP) levels in 36.8% of AAA patients were more than 20 micrograms/dl. Based on these findings, patients with low GMBF were treated postoperatively with H2-blocker, and patients with CC were treated preoperatively with heparin. After these treatments, only 1 of 38 AAA patients developed postoperative upper GI tract bleeding and could be treated conservatively after 1988, whereas in prior years postoperative upper GI tract bleeding developed in 7 of 112 patients, three of whom required emergency surgery.
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PMID:Prevention of gastric ulcer or acute gastric mucosal lesions accompanying bleeding after abdominal aortic aneurysm surgery. 784 24

We present an autopsy case of aortoduodenal fistula complicated by both gastric carcinoma and acute gastric mucosal lesions(AGML). A 73-year-old man with a past history of gastric ulcer, myocardial infarction, and arteriosclerosis of the right femoral artery presented to Osaka National Hospital complaining of intermittent claudication of the right lower extremity. After a diagnosis of arteriosclerosis obliterans, percutaneous angioplasty was performed. The postoperative course was initially good. However, two weeks after the angioplasty procedure he suddenly vomited blood. Emergency endoscopy revealed both polypoid gastric carcinoma and AGML, which were considered to be the major cause of his gastrointestinal bleeding. And he died of uncontrollable gastrointestinal bleeding two weeks after this examination. Autopsy showed an atherosclerotic aneurysm of the abdominal aorta that had ruptured into the third part of the duodenum. To our knowledge, there has been no previous autopsy on a primary aortoduodenal fistula from an atherosclerotic abdominal aneurysm complicated by similar hemorrhagic gastric lesions. This case emphasizes the difficulty of making a clinical diagnosis of primary aortoduodenal fistula.
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PMID:[An autopsy case of primary aortoduodenal fistula complicated by both gastric carcinoma and acute gastric mucosal lesions]. 1121 89

Recent reports suggested an increase in the occurrence of gastroduodenal ulcers in old age people. And it was reported that gastroduodenal ulcers in old age generation has the characteristics which was different from that in young generation. Namiki et al reported that gastric ulcer in old age generation occurs often at the gastric corpus and is larger and deeper and more often with bleeding comparing with that in young people. Furthermore NSAID ulcer is known to occur more often in old age than in young. Although the pathogenesis of the gastroduodenal ulcer in old age is not clear, a decrease in gastric mucosal blood flow with aging might be related that is possibly due to narrowing of arteries based on arteriosclerosis. Since the report by Virchow that suggested the importance of vessels as a cause for gastric ulcer, many studies indicated the involvement of vessels in the pathogenesis of gastroduodenal ulcer. Until recently, however, there were no methods except autopsy to evaluate the severity of arteriosclerosis, therefore the involvement of arteriosclerosis in the pathogenesis was not clarified. Recently a new device that case evaluate the arteriosclerosis by the measuring pulse wave velocity was developed and is now widely used. We undertook to clarify the relation between arteriosclerosis and gastroduodenal ulcer. The result suggested the involvement of arteriosclerosis in the pathogenesis of gastroduodenal ulcer, especially of NSAID ulcer with bleeding. In this manuscript, we refer to the previous reports that suggest the relation between arteriosclerosis and gastroduodenal ulcer.
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PMID:[Arteriosclerosis and gastoduodenal ulcer]. 1503 98

Morinda citrifolia, also known as Great Morinda, Indian Mulberry, or Noni, is a plant belonging to the family Rubiaceae. A number of major chemical compounds have been identified in the leaves, roots, and fruits of Noni plant. The fruit juice is in high demand in alternative medicine for different kinds for illnesses such as arthritis, diabetes, high blood pressure, muscle ached and pains, menstrual difficulties, headache, heart diseases, AIDS, gastric ulcer, sprains, mental depression, senility, poor digestion, arteriosclerosis, blood vessel problems, and drug addiction. Several studies have also demonstrated the anti-inflammatory, antioxidant and apoptosis-inducing effect of Noni in various cancers. Based on a toxicological assessment, Noni juice was considered as safe. Though a large number of in vitro, and, to a certain extent, in vivo studies demonstrated a range of potentially beneficial effects, clinical data are essentially lacking. To what extent the findings from experimental pharmacological studies are of potential clinical relevance is not clear at present and this question needs to be explored in detail before an recommendations can be made.
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PMID:Do the health claims made for Morinda citrifolia (Noni) harmonize with current scientific knowledge and evaluation of its biological effects. 2408 91