Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038220 (
status epilepticus
)
7,272
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of new and potent NOS inhibitors, S-methyl-L-thiocitrulline (S-Me-TC), 3-bromo 7-nitro indazole (3-Br-7-NI), and 1-(2-trifluoromethylphenyl) imidazole (
TRIM
), were examined on the pilocarpine-induced seizures in mice. 3-Br-7-NI and
TRIM
decreased the frequency of
status epilepticus
and mortality, while
TRIM
. In addition, significantly reduced the incidence of seizures. The latencies to onsets of seizures,
status epilepticus
, and mortality were significantly prolonged by all three NOS inhibitors, while duration of seizures was reduced by 3-Br-7-NI and
TRIM
. These data suggest an excitatory effect of NO in the neuronal structure involved in the pilocarpine-induced seizures.
...
PMID:Anticonvulsant activity of new and potent inhibitors of nitric oxide synthase. 922 32
