Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038220 (status epilepticus)
 7,272 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven cases of SLE with concomitant neurological syndromes are reported. In 2 cases brain stroke with right-sided hemiplegia and aphasia developed, in the remaining cases brain-stem stroke with subarachnoid haemorrhage, progressive hemiparesis and signs of intracranial hypertension, chorea, status epilepticus in terminal uraemia were observed. In one case myasthenia coexisted. Severe neurological syndromes were preceded by signs of involvement of other organs and in most cases by low-grade signs of central nervous system involvement. Treatment with corticosteroids and immunosuppressants resulted in significant improvement without complete remission. A retrospective survey of clinical material showed that modern therapeutic methods have improved the prognosis in systemic lupus erythematosus independently of central nervous system involvement.
Neurol Neurochir Pol 1979
PMID:[Neurological syndromes in the course of systemic lupus erythematosus]. 52 35

Sixty-five cases of status epilepticus in 51 children were analysed. In 8 cases permanent damage to the CNS resulted and 4 children died. The analysis indicates that the factors influencing the frequency of status epilepticus and CNS damage include: young age of children, infections and their type, withdrawal of antiepileptic medication and the time of beginning treatment of status epilepticus as well as the type of drugs used. In prevention of repeated seizures the authors suggest early administration of anticonvulsants with dehydrating drugs, antipyretics and anti-inflammatory agents. The authors suggest also increasing of the dosage of anticonvulsants in cases of enen common infections beginning in epileptic children.
Neurol Neurochir Pol
PMID:[Analysis of the possibilities of prevention of status epilepticus as well as its complications in children]. 126 33

The purpose of this work was to assess the effects of DPH on a developed epileptogenic focus in cats with split cerebral hemispheres. The investigations were carried out on 12 cats with a chronic epileptogenic focus produced by means of aluminum method in the right motor area. In all cats the epileptogenic focus was found in EEG. All animals received DPH in daily doses of 8-15 mg/kg. In 2 cats they appeared before beginning of treatment. One of these cats died after 3 days from status epilepticus, the other survived status epilepticus and died after 42 days of DPH administration with signs of intoxication. In 3 cats clinical seizures developed during DPH treatment after 30.84 and 210 days. DPH was given during from 171 to 314 days. Clinical seizures appeared in these cats only sporadically and the animals were sacrificed after completion of investigations. In 7 out of 12 cats clinical seizures failed to develop despite presence of bioelectrically active epileptogenic seizures in the right motor area. Administration of DPH in cats with developed epileptogenic focus failed to prevent clinical seizures. In cats with seizures their control was limited by drug toxicity. In all animals toxic effects were observed although the serum DPH level was in the range 8-20 mug/ml.
Neurol Neurochir Pol
PMID:[Effect of diphenylhydantoin on a developed epileptogenic focus in cats with split cerebral hemispheres]. 126 39

Seizures produced by systemic administration of pilocarpine hydrochloride, a cholinergic muscarinic agonist, in rodents are proposed as a useful animal model of epilepsy. Pilocarpine-induced seizures in rats and mice are characterized by sequential development of behavioral and electrographic signs, which are followed by widespread damage to the forebrain (hippocampus, amygdala, thalamus, olfactory cortex, neocortex and substantia nigra). Spontaneous seizures may be observed in the long-term period following the administration of convulsant doses of pilocarpine. In experiments designed to examine neuronal networks engaged in the generation and spread of pilocarpine-induced convulsions, a marked role for the basal ganglia is demonstrated. The caudate-putamen, the substantia nigra and the entopeduncular nucleus were found to govern the propagation of seizures produced by pilocarpine. The antiepileptic potential of drugs (diazepam, clonazepam, phenobarbital, valproic acid and trimethadione) against pilocarpine-induced convulsions correlates with their depressant action on the spontaneous activity of non-dopaminergic cells in the substantia nigra. Developmental studies show age-dependent differences in the convulsant response of rats to pilocarpine and status epilepticus are first noted in 2-3 week-old rats, but there is no clear-cut correlation between seizures and evolution of brain damage at this age. The adult pattern of the damage to forebrain is seen after a delay of 1-2 weeks relative to the development of seizures and status epilepticus. The research on the pilocarpine model of convulsions and other cholinergically mediated seizure syndromes may be of value for designing new therapeutic approaches to epilepsy in.
Pol J Pharmacol Pharm
PMID:The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents. 333 12

The presented material comprised 17 cases observed in four Warsaw hospitals in a period of 20 years. Nine patients with the pseudotumour syndrome were diagnosed correctly and referred to neurosurgical services. The remaining eight cases died in neurological hospital departments with the following clinical diagnoses: cerebral stroke 3, subarachnoid haemorrhage 1, comatose state preceded by dementia 1, chronic meningoencephalitis 1, status epilepticus 2 cases postmortem investigations demonstrated cerebral cysticercosis in all cases. In four patients with predominant symptoms of cerebrovascular disease lesions were found of the type of residual vasculitis cysticercosa, the sequelae of which might have caused secondary complications independent of concomitant arteriosclerosis. Dementia appeared in a patient with huge hydrocephalus consequent to numerous cysticerci. The patient with the diagnosis of meningoencephalitis had an inflammatory reaction of the ependyma and meninges caused by a cysticercus floating in the IV ventricle. Of the patients dying in status epilepticus attention is called to a 6-year-old girl with a solitary cysticercus localised subcortically in the motor area. The authors suggest that the possibility of cysticercosis should be kept in mind, despite its rarity, in cases with a not completely clear clinical manifestations of cerebrovascular disease, chronic meningoencephalitis and epilepsy or dementia.
Neurol Neurochir Pol
PMID:[Neuropathologic analysis of 8 undiagnosed cases of cerebral cysticercosis]. 344 11

The effects of 2-chloroadenosine (2-CLA), a metabolically stable analog of adenosine, and aminophylline, an adenosine receptor antagonist, on seizures produced by pilocarpine (PILO) were examined in rats. The effects of 2-CLA on amygdaloid and hippocampal kindled seimres were also examined. In the animals pretreated with aminophylline (25-100 mg/kg), a non-convulsant dose of PILO (100 mg/kg) resulted in severe motor limbic seizures which rapidly evolved to status epilepticus. 2-CLA (5-10 mg/kg) blocked the appearance of behavioral and EEG seizures produced by a convulsant dose of PILO (380 mg/kg) and completely blocked the evolution of hippocampal and amygdaloid kindled seizures. The results indicate that purinergic mechanisms are involved in the modulation of seizure threshold within the limbic system.
Pol J Pharmacol Pharm
PMID:Anticonvulsant role of adenosine. 350 33

Late results of epilepsy treatment in 150 children hospitalized in the Department of Psychiatry, Institute of Paediatrics, Medical Academy in Warsaw and followed-up in the outpatient clinic of this Department are described. The criteria of selection of the cases for analysis were age of 10 years, at least, and disease duration at least 4 years. It was found that in 72% of cases the seizures had been completely controlled (absent for at least 2 years). In 28% the seizures continued despite systematic treatment. The analysis showed that persistence of seizures was caused, among other factors, by the degree and extent of the organic damage to the central nervous system confirmed in neurological and psychological examination and electroencephalographic investigations, the type of seizures, mainly seizures of salaam type and partial seizures with complex signs, recurring status epilepticus, and coexistence of various types of seizures in a child. Interseizure psychic disturbances were more frequently observed in children in whom the seizures could not have been controlled completely.
Neurol Neurochir Pol
PMID:[Catamnestic studies of children with epilepsy]. 361 17

The authors describe in the light of an own case the clinical manifestations and electroencephalographic findings in status epilepticus with psychomotor seizures.
Neurol Neurochir Pol
PMID:[A case of status epilepticus with psychomotor seizures]. 378 56

The authors studied 286 patients with epilepsy with disease onset past the age of 20 years (176 males, 110 females) from the urban and rural populations. In 57% of cases the aetiology of epilepsy was undetermined. Among the known aetiological factors head trauma accounted for 15.5% of cases, inflammatory processes in the central nervous system for 4.5%, alcoholism for 7%, vascular lesions for 6%, tumours for 5.2%, degenerative and atrophic changes for 1.5%. Over 40% of patients had had attacks for up to 15 years and over 18% for over 20 years. In 80% of cases grand mal seizures occurred, and in 33% of these cases more than 12 attacks occurred annually. Six cases of status epilepticus were observed with 2 deaths. The attacks were precipitated by menstruation, alcohol abuse, infection, stressed, television watching. Among the signs accompanying or following the seizures tongue biting and urination prevailed. Neurological signs were demonstrated in 21% of cases, encephalopathy in 65%, other psychic disturbances in 9.5%. Systematic treatment was received by 75% of the patients (over 80% in urban population), and therapy with multiple drugs was most frequent. Drug-resistant epilepsy was found in 34% of cases. The patients from the rural population had a lower educational level and had more children. About 70% of the patients were in employment.(ABSTRACT TRUNCATED AT 250 WORDS)
Neurol Neurochir Pol
PMID:[Analysis of clinico-social features of epilepsy]. 404 96

Status epilepticus with generalized seizures may sometimes develop in epileptic patient who does not recover between attacks. Such a state is life-threatening and requires immediate intervention. Own experience with 22 patients suffering from status epilepticus out of 100 epileptic patients treated at the hospital. Management of status epilepticus is also discussed. Diazepam should be given intravenously or clonazepam with phenytoin as the drugs of the first choice. Then, barbiturates are given to produce coma. If the disease is progressing, the third choice drugs are also discussed.
Pol Tyg Lek
PMID:[Status epilepticus: clinical features, causes and management]. 802 34


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