Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038220 (status epilepticus)
 7,272 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-four adult male Wistar rats were used in this study. Status epilepticus was provoked in 10 rats by embedding coriaria lactone particle into the left cerebral motor cortex. In the controls were embedded particles without coriaria lactone. After 6 h of continuous seizure, the locus coeruleus was studied with the noradrenaline (NA) fluorescence histochemical technique and enzyme histochemical test for monoamine oxidase (MAO). The intensity of NA fluorescence was detected with fluorescent microscope autoexposuremeter and analysed with MIAS-200 Image Analyser. The study group showed a parallel increase of NA fluorescence as compared with that of the control group by both measurements. NA plays an inhibitory role in the cortex. Our data suggest that the increase of NA in locus coeruleus may be due to the reduction of NA release from axon terminal. Reduction in inhibition could be one of the mechanisms of seizure activity. The intensity of MAO was detected with MIAS-200 Image Analyser. The regulation of monoamine metabolism by MAO in the central nervous system and the increase of MAO activity in the continuous seizure group may be induced by the accumulation of NA in the locus coeruleus soma.
Hua Xi Yi Ke Da Xue Xue Bao 1992 Jun
PMID:[Histochemical and image-analytic study of the rat locus coeruleus during status epilepticus]. 145 44

We studied the amount of dopamine on the substantia nigra-ventral tegmental area during status epilepticus of male Wistar rats induced by coriaria lactone with fluorescence histochemical technique and autoexposuremeter of microscope. The intensity of dopamine fluorescence in the climax epileptic seizure group (10 rats) and postepileptic seizure group (8 rats) decreased significantly as compared with the control (10 rats), but the intensity of dopamine fluorescence in the pre-eileptic seizure group (10 rats) was not significantly different from that of the control group. The result indicated that epileptic seizure induces a decrease of the inhibitory neurotransmitter-dopamine. Therefore dopamine plays an important role in regulating the epileptic seizures.
Hua Xi Yi Ke Da Xue Xue Bao 1994 Sep
PMID:[Histochemical study of dopamine on rat substantia nigra--ventral tegmental area during status epilepticus]. 789 43