Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038220 (
status epilepticus
)
7,272
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Actin-depolymerizing factor
(
ADF
)/cofilin is a small cytoskeletal protein that is a stimulus-responsive mediator of actin dynamics.
ADF
/cofilin also translocates into mitochondria and nuclei in response to apoptotic stimuli for cytochrome c release. These
ADF
/cofilin translocations are negatively regulated by phosphorylation. Recently, it has been reported that pyridoxal-5'-phosphate (PLP) phosphatase/chronophin (PLPP/CIN) regulates phosphorylation of
ADF
/cofilin levels. Therefore, we investigated whether PLPP/CIN contributes to apoptosis-like events via modulation of
ADF
/cofilin phosphorylation following
status epilepticus
(SE). In the present study, apoptosis-like astroglial damages were detected in the dentate gyrus after SE. Upregulation of
ADF
/cofilin and PLPP/CIN expression in the cytoplasm and nucleus were accompanied by apoptosis-like events. PLPP/CIN level showed a direct proportionality to nuclear translocation of
ADF
/cofilin. Moreover, nuclear accumulation of apoptosis-inducing factor was simultaneously observed with that of
ADF
/cofilin. Tat-PLPP/CIN pretreatment accelerated astroglial apoptosis-like degeneration following SE, although Tat-PLPP/CIN transduction alone could not induce apoptosis or necrosis in astrocytes. Therefore, our findings suggest that nuclear accumulation of
ADF
/cofilin itself may not induce apoptogenic events, but may play a synergic role in apoptosis-like astroglial loss following SE.
...
PMID:Pyridoxal-5'-phosphate phosphatase/chronophin induces astroglial apoptosis via actin-depolymerizing factor/cofilin system in the rat brain following status epilepticus. 2073 71
