Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038220 (
status epilepticus
)
7,272
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Endothelin-1
(
ET-1
) is one of potential factors to induce vasogenic edema formation, since exogenous
ET-1
treatment decreases aquaporin 4 (AQP4) expression and increases chemokines induction. To identify the role of endogenous
ET-1
in vasogenic edema formation, we examined the correlation between endogenous
ET-1
expression and vasogenic edema formation in the pirifom cortex following
status epilepticus
(SE). In the present study, SMI-71 (a brain-blood barrier marker) immunoreactivity was significantly reduced in blood vessels at 1 day after SE when vasogenic edema and neuronal damage were observed.
ET-1
expression was up-regulated in endothelial cells prior to reduction in SMI-71 immunoreactivity. Furthermore,
ET-1
expressing endothelial cells showed the absence of SMI-71 immunoreactivity. Increase in
ET-1
expression was followed by reduced AQP4 immunoreactivity prior to vasogenic edema formation. Only a few microglia showed monocyte chemotactic protein-1 (a chemokine induced by
ET-1
) outside vasogenic edema lesion. Taken together, our findings suggest that endothelial
ET-1
expression may contribute to SE-induced vasogenic edema formation via brain-blood barrier disruption at AQP4/MCP-1 independent manners.
...
PMID:Up-regulation of endothelial endothelin-1 expression prior to vasogenic edema formation in the rat piriform cortex following status epilepticus. 2174 16
