Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038220 (
status epilepticus
)
7,272
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ruthenium red
was administered to mice and cats intracranially or intraperitoneally. In mice, intracisternal administration produced
status epilepticus
and tonic convulsions. In contrast, intraperitoneal administration induced total flaccid paralysis lasting several hours. These effects of
Ruthenium red
were partially blocked by the simultaneous administration of CaCl2. EDTA, at doses much greater than those of
Ruthenium red
, produced effects similar to those of the dye, which were also blocked by CaCl2 administration. In cats, intraventricular or intrahippocampal administration of
Ruthenium red
through a permanently implanted cannula produced after a few minutes subclinical paroxysmal activity in all brain regions recorded. After several hours the animals developed typical grand mal seizures. Intraperitoneal injection of
Ruthenium red
to cats did not affect the EEG but markedly depressed muscular activity. Administration of carbachol to the latter animals produced myoclonic responses. These results are discussed in relation to the inhibitory effect of
Ruthenium red
on Ca2+ transport and binding to membranes, and to the role of this cation on neurotransmitter release.
...
PMID:Convulsions or flaccid paralysis induced by ruthenium red depending on route of administration. 82 18
