Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038220 (status epilepticus)
 7,272 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cadherin family consists of several homophilic adhesion molecules that, together with their intracellular binding partners the catenins, are known to mediate axonal navigation, target recognition, and synapse formation during development. Here, we have examined the potential role of these molecules in axonal sprouting induced in the adult brain. Over a period of 3 to 60 days, an episode of pilocarpine-induced status epilepticus (SE) led to sprouting of hippocampal mossy fibers both into the CA3 pyramidal cell layer and the inner molecular layer of the dentate gyrus (DG). We found focal up-regulation of N-cadherin, beta-catenin, and alpha-catenin immunoreactivity within segments of the CA3 pyramidal cell layer with pronounced neuron loss that was associated with the development of mossy fiber sprouting. In contrast, expression of these 3 molecules was unaltered in the DG molecular layer despite mossy fiber sprouting in this area. The levels of E-cadherin immunoreactivity were altered prior to the detection of mossy fiber sprouting, with a general reduction in the neuropil and increased expression in CA1/CA3 pyramidal cell somata. Our results imply that members of the cadherin/catenin families undergo specific spatiotemporal patterns of regulation, which may be important in axon target recognition and synapse formation during lesion-induced sprouting.
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PMID:Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. 1238 56

Recurrent seizures can induce mossy fiber sprouting (MFS), of the hippocampal dentate gyrus, and synaptic reorganization in mature brain. This changes local circuits and provides a structural basis for epileptogenesis in the hippocampus. However, the mechanisms of MFS and synaptic reorganization still remain unclear. Neural-cadherin (N-cadherin), a calcium adhesion molecule, plays an important role in neurite outgrowth, pathfinding, and synaptic specificity of early central nervous system development. It is unknown whether N-cadherin is involved in MFS after seizures in mature brain. To further examine the correlation between MFS and N-cadherin expression, we separately labeled MFS and N-cadherin with Timm staining and antibody in adult rats after status epilepticus (SE). Timm staining revealed that MFS is observed in the inner molecular layer of dentate gyrus of rats 2 and 4 weeks after SE. The observed MFS migrated from the hilus to the granule cell layer, gradually extending axons into the inner molecular layer to form an intense band. Immunohistochemical staining of N-cadherin revealed that the upregulated expression of N-cadherin was concentrated in the position of mossy fiber axonal sprouts of rats 1-4 weeks after SE, and that it was earlier than MFS. The spatial and temporal distribution consistence of N-cadherin and Timm staining supported the correlation that exists between N-cadherin expression and the process of aberrant MFS. This result suggests that N-cadherin may be involved in the pathfinding and synaptic specificity of MFS in mature brain after seizures, and can play an important role in the targeted growth of mossy fibers.
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PMID:Spatiotemporal profile of N-cadherin expression in the mossy fiber sprouting and synaptic plasticity following seizures. 2172 Jul 65