Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038220 (status epilepticus)
 7,272 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Influenza encephalopathy(IE) is characterized by its high incidence in Japanese children between 1 year and 5 years of age, its onset in the first or the second day of illness and its high mortality (15-30%) and morbidity (25-40%). We proposed the classification of IE with poor prognosis from the neuroradiological findings. Four types of encephalopathy seem to be differentiated from each other, 1. acute necrotising encephalopathy(ANE) type, 2. hemorrhagic shock and encephalopathy syndrome (HSES) type, 3. acute brain swelling(ABS) type, 4. acute encephalopathy with febrile convulsive status epilepticus (AEFCSE) type. The notable radiological features are thalamic lesions in ANE, diffuse cerebral cortical cytotoxic edema in HSES, reversible cerebral swelling in ABS which sometimes reaches lethal brain herniation, and localised cerebral edema which is called as "lobar edema" because its extent seems to be equivalent to cerebral lobes. "Lobar edema" is developed about four days after status epilepticus simultaneously with the onset of repetitious focal seizure and neurological deterioration. The radiological changes in the early phase of IE are described in each types. In conclusion IE is a constellation of different types of encephalopathy although a further research of encephalopathy is urgently needed.
 ...
PMID:[Neuroradiological findings in the acute stage of influenza encephalopathy]. 1703 64

Influenza encephalopathy is characterized by high fever, disturbance of consciousness following influenza virus infection. We encountered 2 adult patients with influenza-associated acute necrotizing encephalopathy (Case 1, a 70-year-old woman with diabetes; Case 2, a 49-year-old woman with multiple myeloma), showing hemorrhagic lesions in the bilateral thalamus. Case 1 presented with fever and disturbance of consciousness followed by status epilepticus, and Case 2 developed fever and drowsiness as initial manifestation. Influenza type A was positive in Case 1 and influenza type B was positive in Case 2. In the acute phase, 2 patients required respiratory ventilation and were treated with anti-influenza drug, steroid and immunoglobulin. Cognitive impairment remained in the both patients in the chronic phase. When acute necrotizing encephalopathy is suspected, intensive treatment should be started as early as possible to improve clinical outcome of patients.
 ...
PMID:[Two adult patients with acute necrotizing encephalopathy following influenza virus infection]. 3195 99